SYNTHESIS AND IN VITRO ANTIMICROBIAL EVALUATION OF NOVEL TRIFLUOROMETHYL SUBSTITUTED PYRAZOLO [3,4-B]PYRIDINE 6-ONE DERIVATIVES

2016-10-16T02-20-53Z
Source: Indo American Journal of Pharmaceutical Research
Kailas R. Labhade*, Madhukar N. Jachak, Shivaji R. Labhade, Avinash S.Kale, Vishwas B. Gaikwad.
A series of novel trifluoromethyl substituted pyrazolo[3,4-b]pyridine -6 one derivatives have been synthesized using the catalytic amount of p-Toluene sulphonic acid in refluxing ethanol. IR, 1H NMR, 13C NMR and HRMS data elucidated the structures of the all newly synthesized compounds. All newly synthesized compounds were screened for their antimicrobial activity towards Gram-positive and Gram-negative bacterial strains and antifungal activity towards C. albicans, F. solani, A. niger at various concentration. Results showed that majority of compounds have significant antibacterial and antifungal activity. Compound 4a and 4b found to have excellent antibacterial activity, while compound 4a and 4d have excellent antifungal activity.


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