Publication date: September 2018
Source: Anesthesiology Clinics, Volume 36, Issue 3
Author(s): Christopher A.J. Webb, T. Edward Kim
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Δευτέρα 6 Αυγούστου 2018
Establishing an Acute Pain Service in Private Practice and Updates on Regional Anesthesia Billing
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Enhanced Recovery After Shoulder Arthroplasty
Publication date: September 2018
Source: Anesthesiology Clinics, Volume 36, Issue 3
Author(s): Taras Grosh, Nabil M. Elkassabany
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Forthcoming Issues
Publication date: September 2018
Source: Anesthesiology Clinics, Volume 36, Issue 3
Author(s):
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Contributors
Publication date: September 2018
Source: Anesthesiology Clinics, Volume 36, Issue 3
Author(s):
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Regional Anesthesia
Publication date: September 2018
Source: Anesthesiology Clinics, Volume 36, Issue 3
Author(s): Nabil M. Elkassabany, Edward R. Mariano
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The influence of trait empathy on reactive aggression: An ERP study
Publication date: Available online 7 August 2018
Source: International Journal of Psychophysiology
Author(s): Ping Song, Zhuo Zhang, Bo Wang, David Nussbaum, Hui Zhao, Qianglong Wang, Yuqing Xiao, Bo Yang
Abstract
This study mainly investigated the electrophysiological mechanism underlying the effect of trait empathy on reactive aggression using event-related potentials (ERPs). Firstly, we computed the correlation between trait empathy and trait aggression in 413 male undergraduates. The trait empathy was positively correlated with trait aggression, whereas the perspective taking (cognitive empathy) and the empathic concern (affective empathy) dimensions of trait empathy were negatively correlated with physical aggression. Subsequently, we selected 50 young male undergraduates respectively with high empathy (25) and low empathy (25) to complete a competitive reaction time task (a modified version of the Taylor Aggression Paradigm) against two mock opponents in high and low provocation conditions. The high empathy group selected lower average punishments against their opponents than the low empathy group. In the decision phase, high provocation elicited an enlarged ERP negativity compared to low provocation in the high empathy group. This observation was absent in the low empathy group. In the outcome phase, a feedback related negativity was observed in both groups. The low empathy group, but not the high empathy group, showed a significant average amplitude difference for losing and winning trials. The lack of a difference in ERP negativity amplitude in high empathy group suggests that punishing and being punished by opponents have a similar negative valence for this group.
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The Use of Microtechnology to Quantify the Peak Match Demands of the Football Codes: A Systematic Review
Abstract
Background
Quantifying the peak match demands within the football codes is useful for the appropriate prescription of external training load. Wearable microtechnology devices can be used to identify the peak match demands, although various methodologies exist at present.
Objectives
This systematic review aimed to identify the methodologies and microtechnology-derived variables used to determine the peak match demands, and to summarise current data on the peak match demands in the football codes.
Methods
A systematic search of electronic databases was performed from earliest record to May 2018; keywords relating to microtechnology, peak match demands and football codes were used.
Results
Twenty-seven studies met the eligibility criteria. Six football codes were reported: rugby league (n = 7), rugby union (n = 5), rugby sevens (n = 4), soccer (n = 6), Australian Football (n = 2) and Gaelic Football (n = 3). Three methodologies were identified: moving averages, segmental and 'ball in play'. The moving averages is the most commonly used (63%) and superior method, identifying higher peak demands than other methods. The most commonly used variables were relative distance covered (63%) and external load in specified speed zones (57%).
Conclusion
This systematic review has identified moving averages to be the most appropriate method for identifying the peak match demands in the football codes. Practitioners and researchers should choose the most relevant duration-specific period and microtechnology-derived variable for their specific needs. The code specific peak match demands revealed can be used for the prescription of conditioning drills and training intensity.
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Jack‐of‐many‐trades: discovering new roles for troponin c
The Journal of Physiology, Volume 0, Issue ja, -Not available-.
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Linkage Disequilibrium and Evaluation of Genome-Wide Association Mapping Models in Tetraploid Potato
Genome-wide association studies (GWAS) have become a powerful tool for analysing complex traits in crop plants. The current study evaluates the efficacy of various GWAS models and methods for elucidating population structure in potato. The presence of significant population structure can lead to detection of spurious marker-trait associations, as well as mask true ones. While appropriate statistical models are needed to detect true marker-trait associations, in most published potato GWAS, a 'one model fits all traits' approach has been adopted. We have examined various GWAS models on a large association panel comprising diverse tetraploid potato cultivars and breeding lines, genotyped with single nucleotide polymorphism (SNP) markers. Phenotypic data was generated for 20 quantitative traits assessed in different environments. Best Linear Unbiased Estimates (BLUEs) for these traits were obtained for use in assessing GWAS models. Goodness of fit of GWAS models, derived using different combinations of kinship and population structure for all traits, was evaluated using Quantile-Quantile (Q-Q) plots and genomic control inflation factors (GC). Kinship was found to play a major role in correcting population confounding effects and results advocate a 'trait-specific' fit of different GWAS models. A survey of genome-wide linkage disequilibrium (LD), one of the critical factors affecting GWAS, is also presented and our findings are compared to other recent studies in potato. The genetic material used here, and the outputs of this study represent a novel resource for genetic analysis in potato.
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Null Mutation of the Fascin2 Gene by TALEN Leading to Progressive Hearing Loss and Retinal Degeneration in C57BL/6J Mice
Fascin2 (FSCN2) is an actin cross-linking protein that is mainly localized in retinas and in the stereocilia of hair cells. Earlier studies showed that a deletion mutation in human FASCIN2 (FSCN2) gene could cause autosomal dominant retinitis pigmentosa. Recent studies have indicated that a missense mutation in mouse Fscn2 gene (R109H) can contribute to the early onset of hearing loss in DBA/2J mice. To explore the function of the gene, Fscn2 was knocked out using TALEN (transcription activator-like effector nucleases) on the C57BL/6J background. Four mouse strains with deletions of 1, 4, 5, and 41 nucleotides in the target region of Fscn2 were developed. F1 heterozygous (Fscn2+/-) mice carrying the same deletion of 41 nucleotides were mated to generate the Fscn2-/- mice. As a result, the Fscn2-/-mice showed progressive hearing loss, as measured in the elevation of auditory brainstem-response thresholds. The hearing impairment began at age 3 weeks at high-stimulus frequencies and became most severe at age 24 weeks. Moreover, degeneration of hair cells and loss of stereocilia were remarkable in Fscn2-/-mice, as revealed by F-actin staining and scanning electron microscopy. Furthermore, compared to the controls, the Fscn2-/-mice displayed significantly lower electroretinogram amplitudes and thinner retinas at 8, 16, and 24 weeks. These results demonstrate that, in C57BL/6Jmice, Fscn2 is essential for maintaining ear and eye function and that a null mutation of Fscn2 leads to progressive hearing loss and retinal degeneration.
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AT&T and RapidDeploy Team Up to Advance Emergency Response Capabilities With Cloud-Based Solutions
Cloud-Based Computer-Aided Dispatch Solution Helps Boost Situational Awareness for Dispatchers and First Responders DALLAS, Aug. 6, 2018 - AT&T* and RapidDeploy formed a new relationship that enables AT&T to provide Public Safety Answering Points (PSAPs) access to RapidDeploy's cloud-based Computer-Aided Dispatch (CAD) platform. RapidDeploy is a modern update to the dispatch solutions...
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Visual expertise for print in schizophrenia: Analysis of the N170 component
Publication date: Available online 6 August 2018
Source: International Journal of Psychophysiology
Author(s): Maxime Curzietti, Anne-Clémence Chaillou, Anne Bonnefond, Pierre Vidailhet, Nadège Doignon-Camus
Abstract
Reading deficits have been reported for patients suffering from schizophrenia namely, specific phonological processing deficits. Phonological processing skills are crucial in the learning-to-read process as they are necessary to develop visual expertise for print, which reflects the neural specialization for print. The present study is the first to test visual expertise for print in patients suffering from schizophrenia by measuring the N170 component. Patients and pair-matched healthy control participants performed a lexical decision task, in which words and symbols were presented. As expected, larger N170 amplitudes to word than to control stimuli were observed at the left occipito-temporal site PO7 but not at the PO8. More importantly, the modulation of the N170 as a function of the stimulus and hemisphere did not vary between patients and controls. This result suggests preserved visual expertise for print processing in patients suffering from schizophrenia.
Graphical abstract
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Including women in research. It's necessary, and really not so hard to do
Experimental Physiology, Volume 0, Issue ja, -Not available-.
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Increase in lactate without change in nutritive blood flow or glucose at active trigger points following massage: A randomized clinical trial
Publication date: Available online 6 August 2018
Source: Archives of Physical Medicine and Rehabilitation
Author(s): Albert F. Moraska, Robert C. Hickner, Rachael Rzasa-Lynn, Jay P. Shah, Jonathan R. Hebert, Wendy M. Kohrt
Abstract
Objective
To investigate changes in nutritive blood flow as well as interstitial glucose and lactate within an active myofascial trigger point (MTrP) following massage.
Design
Randomized, placebo-controlled trial.
Setting
Subjects were recruited from the general population; procedures were conducted at a research center affiliated with a university hospital.
Participants
Twenty-five adults (18-49 years old) with episodic or chronic tension-type headache and an active MTrP in the upper trapezius muscle.
Interventions
Subjects were randomized to receive a single trigger point release (TRP) massage or sham ultrasound (US) treatment at an active MTrP in the upper trapezius muscle. Microdialysis was used to continuously sample interstitial fluid from the MTrP before, during, and for 60 min following intervention.
Main Outcome Measures
The primary outcome measure was nutritive blood flow within the MTrP as measured by microdialysis ethanol clearance; secondary measures included dialysate glucose, dialysate lactate, and subject discomfort with the procedures. Pressure-pain threshold (PPT) was determined to assess treatment effectiveness.
Results
There was no treatment effect of TPR massage on nutritive blood flow (p=0.663) or dialysate glucose (p=0.766). The interaction for lactate was significant indicating that dialysate lactate increased for TPR massage versus sham US (p=0.04); maximum lactate increase over baseline was observed at 60 minutes after TPR massage (p=0.007, 0.128 μM, 95% CI 0.045-0.212). Pain evoked by probe placement into an active MTrP was low. An interaction effect on PPT was significant (p= 0.005).
Conclusion
TPR massage of an active MTrP affected anaerobic metabolism as represented by an increase in dialysate lactate without change in nutritive blood flow or dialysate glucose. The lack of a treatment effect on blood flow is discussed.
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The Role of Emotional Intelligence in Community Integration and Return to Work after Acquired Brain Injury
Publication date: Available online 6 August 2018
Source: Archives of Physical Medicine and Rehabilitation
Author(s): Sarah E. Hall, Joanne M. Wrench, Madeleine Connellan, Neira Ott, Sarah J. Wilson
Objective
To investigate whether emotional intelligence skills measured via the Perceiving, Understanding and Managing Emotions branches of the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) V2.0 are associated with community integration and return-to-work (RTW) following moderate-to-severe acquired brain injury (ABI), after accounting for other established predictors.
Design
Retrospective cohort study.
Setting
Outpatient follow-up services within two specialist ABI rehabilitation centers in [location removed].
Participants
Eighty-two individuals with moderate-to-severe ABI discharged from inpatient rehabilitation and living in the community (2 months to 7 years post-injury).
Intervention
Not applicable.
Main outcome measures
Community Integration Questionnaire scores for the total sample (N = 82; age range 18-80) and RTW status (employed vs not employed) for the subset of participants employed prior to ABI (n = 71; age range 19-66).
Results
Hierarchical logistic and multiple regression analyses were used to examine the unique contribution of Perceiving, Understanding and Managing Emotions scores to RTW and community integration, after controlling for demographic, injury-related, psychological and cognitive predictors. As a set, the three EI variables did not explain incremental variance in outcomes. However, individually, Understanding Emotions predicted RTW (adjusted odds ratio = 3.10, p = .03), χ2(12) = 35.52, p < .001, and Managing Emotions predicted community integration (ß = 0.23, p = .036), F(12,69) = 5.14, p < .001.
Conclusion
Although the EI constructs in combination did not improve prediction beyond the effects of established variables, individual components of strategic EI may be important for specific participation outcomes after ABI.
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Four-meter Gait Speed: Normative Values and Reliability Determined for Adults Participating in the NIH Toolbox Study
Publication date: Available online 6 August 2018
Source: Archives of Physical Medicine and Rehabilitation
Author(s): Richard W. Bohannon, Ying-Chih Wang
ABSTRACT
Objectives
To establish reference values and determine test-retest reliability for usual and maximal 4 meter gait speed.
Design
Cross-sectional observational study.
Setting
Offices in 10 geographically dispersed cities in the United States.
Participants
Men and women enrolled in the National Institutes of Health ToolBox norming study.
Intervention
Not applicable.
Main Outcome Measures
Specifically used were data from 18 to 85 year old men and women who were timed over 4 meters (after a static start) while walking at their usual and maximum speeds. Norms for usual and maximum gait speed were derived using data from 1320 participants. Test-retest reliability for 164 participants was described using paired t-tests, intraclass correlation coefficients (ICCs) and minimal detectable changes (MDCs).
Results
Mean usual speed was 1.12 m/s, whereas mean maximum speed was 1.61 m/s. As a general linear model showed 4 meter gait speed to differ significantly according to gait condition (speed), gender, and age group; estimates of normal were calculated accordingly. The usual speed of 80 to 85 year old women was lowest at 0.95m/s; the maximum speed of 18 to 29 year old men was highest at 1.85 m/s. Test-retest measures did not differ significantly, but the ICCs were only fair and the MDCs were high.
Conclusions
Normative reference values provided herein may be helpful in interpreting measurements of 4 meter gait speed obtained from adult men and women. The limited reliability of the gait speed measurements, however, limits their usefulness in making judgments regarding change.
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The Effects of Movement-to-Music (M2M) and Adapted Yoga on Physical and Psychosocial Outcomes in People with Multiple Sclerosis
Publication date: Available online 6 August 2018
Source: Archives of Physical Medicine and Rehabilitation
Author(s): Hui-Ju Young, Tapan S. Mehta, Cassandra Herman, Fuchenchu Wang, James H. Rimmer
Abstract
Objective
To investigate the effects of two 12-week exercise training interventions, movement-to-music (M2M) and adapted yoga (AY), on physical and psychosocial outcomes in people with multiple sclerosis (MS).
Design
Three-arm randomized controlled proof-of-concept trial.
Setting
A community-based fitness facility.
Participants
Participants (N=81) with MS (Patient Determined Disease Steps [PDDS] self-reported disease status scores: 0-6) between ages of 18 and 65 years were randomized to: M2M (n=27), AY (n=26), or waitlist control (n=28).
Interventions
Both M2M and AY completed three 60-minute exercise sessions per week for 12 weeks. Waitlist controls received biweekly newsletters via mail that contained educational information on living with MS.
Main Outcome Measures
Primary measures were Timed Up and Go (TUG, seconds), Six-minute Walk Test (6MWT, meters), and Five Times Sit-to-Stand Test (FTSST, seconds). Secondary measures were self-reported outcomes assessed using PROMIS Fatigue and Pain Interference Short Form 8a. Participants were evaluated at baseline and post-intervention. Primary analyses were performed using an intent-to-treat mixed model ANCOVA.
Results
Comparisons across all three groups revealed significant group differences in TUG and 6MWT. Post hoc analyses indicated significant improvements in TUG (LSM difference [95% CI]=-1.9s [-3.3, -0.5], p=0.01, d=0.7) and 6MWT (41.0m [2.2, 80.0], p=0.04, d=0.6; controlled for PDDS) in M2M compared to controls, while no significant differences were observed when compared AY to controls. No significant group differences were found on FTSST, fatigue and pain interference.
Conclusion
Movement-to-music may be a useful and enjoyable exercise form for people with MS in improving mobility and walking endurance and merits long-term study in larger study populations.
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Preparation for colonoscopy: recommendations by an expert panel in Italy
Despite several guidelines on bowel preparation being available, their applicability in Italy is poorly investigated.
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Preparation for colonoscopy: recommendations by an expert panel in Italy
Despite several guidelines on bowel preparation being available, their applicability in Italy is poorly investigated.
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EMS coordination: Healthcare coalitions provide organized cooperation
Healthcare coalitions offer EMS a "seat at the table" for regional emergency planning
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Effect of Helicobacter pylori Infection on GATA - 5 and TFF1 Regulation, Comparison Between Pediatric and Adult Patients
Abstract
Background
GATA factors, which constitute a family of transcription regulatory proteins, participate in gastrointestinal development. Trefoil factor 1 (TFF1) plays a crucial role in mucosal defense and healing, and evidence suggests that GATA-5 mediated its regulation. Gastric cancer is a multiple-step process triggered by Helicobacter pylori and is characterized by accumulation of molecular and epigenetic alteration. The aim of this study was to evaluate the effect of H. pylori infection on the regulation of GATA-5 and TFF1 in vitro and in vivo.
Results
Infected cells exhibited upregulation of GATA-5 and TFF1 after 48 h. An increase in GATA-5 and TFF1 mRNA levels was also found in mice samples after 6 and 12 months of infection, respectively. In human samples, we found an association between H. pylori infection and GATA-5 upregulation. In fact, among H. pylori-infected patients, hypermethylation was observed in 45.5% of pediatric samples, in 62.6% of chronic gastritis samples, and in 63% of gastric cancer samples. Regarding TFF1, the expression levels were similar in pediatrics and adults patients, and were independent of H. pylori infection, and the expression of these factors was downregulated in gastric cancer samples. GATA-5 promoter methylation was associated with a decrease in TFF1 mRNA levels.
Conclusions
Our results suggest that the upregulation of GATA-5 and TFF1 observed in vitro and in vivo may be correlated with a protective effect of the mucosa in response to infection. The epigenetic inactivation of GATA-5 observed in human biopsies from infected patients may suggest that this alteration is an early event occurring in association with H. pylori infection.
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Evolution of eusociality
Evolution of eusociality
Evolution of eusociality, Published online: 06 August 2018; doi:10.1038/s41576-018-0044-8
Insulin signalling underlies the evolution and regulation of eusocial behaviours in ants, posits a recent study in Science.
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Transcriptomics in intact tissues
Transcriptomics in intact tissues
Transcriptomics in intact tissues, Published online: 06 August 2018; doi:10.1038/s41576-018-0045-7
A new RNA sequencing technology reported in Science uses hydrogel-tissue chemistry to enable gene expression profiling in intact tissues.
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Harris Corporation to showcase future-ready, mission-critical solutions at APCO 2018
LAS VEGAS — Harris Corporation (NYSE:HRS) will showcase its converged Land Mobile Radio (LMR)/Long Term Evolution (LTE) and other future-ready, mission-critical solutions that support first responders at the Association of Public-Safety Communications Officials (APCO) 2018 Annual Conference & Expo in Las Vegas August 5-8. (Booth #729) Harris will feature interoperable solutions that...
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3 ways to finance a power stretcher purchase
How can you afford the cost of such an upgrade? Check out these three ways to make your purchase happen
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Survey community disaster preparedness protocols and approaches while traveling
When we travel, we get a chance to see other cities, meet other emergency management professionals and discover hazards that exist for the area we're visiting
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3 ways to finance a power stretcher purchase
How can you afford the cost of such an upgrade? Check out these three ways to make your purchase happen
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The energetics and thermoregulation of water collecting honeybees
Abstract
Honeybees need water for different purposes, to maintain the osmotic homeostasis in adults as well as to dilute stored honey and prepare liquid food for the brood. Water is also used for cooling of the hive. Foraging in endothermic insects is energy-intensive and the question arises how much energy bees invest in a resource without any metabolically usable energy. We investigated the energy demand of water collecting bees under natural conditions. The thermoregulation and energetic effort was measured simultaneously in a broad range of experimental ambient temperatures (Ta = 12–40 °C). The thorax temperature as well as the energetic turnover showed a great variability. The mean Tthorax was ranging from ~ 35.7 °C at 12 °C to nearly 42.5 °C at 40 °C. The energy turnover calculated from CO2-release was highest at a Ta of 20 °C with about 60 mW and lowest at 40 °C with about 22 mW per bee. The total costs during collection decreased from 10.4 J at 12 °C to 0.5 J at 40 °C. The energetic effort of the water collectors was comparable with that of 0.5 M sucrose foraging bees. Our investigation strongly supports the hypothesis that the bees' motivational status determines the energetic performance during foraging.
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Caffeine therapy for apnoea of prematurity: Wake up to the fact that sex matters
Experimental Physiology, Volume 0, Issue ja, -Not available-.
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Establishment and evaluation of COPD model by chronic exposure to MVE combined with LPS instillation
Experimental Physiology, Volume 0, Issue ja, -Not available-.
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Gastric cooling and menthol cause an increase in cardiac parasympathetic efferent activity in healthy adult human volunteers
Experimental Physiology, Volume 0, Issue ja, -Not available-.
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Correlation between neuroanatomical and functional respiratory changes observed in an experimental model of Parkinson's disease
Experimental Physiology, Volume 0, Issue ja, -Not available-.
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Editorial Board
Experimental Physiology, Volume 103, Issue 8, Page 1178-1180, 1 August 2018.
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Reply to the Letter to the Editor: Comments on Doguet et al. (2017) “Muscle length effect on corticospinal excitability during maximal concentric, isometric and eccentric contractions of the knee extensors”
Experimental Physiology, Volume 0, Issue ja, -Not available-.
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Even for EMS providers, depression is human
Acknowledging your depression and getting help is not a sign of weakness, but rather a sign of resilience and strength
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Medic Mindset Podcast: Critical care with Eric Bauer
An EMS educator and flight medic encourages listeners to stay curious about intubation, ventilators and EKGs
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Infraorbital foramen location in the pediatric population: A guide for infraorbital nerve block
Pediatric Anesthesia, EarlyView.
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Feasibility of autologous intraoperative blood collection and retransfusion in small children with complex congenital heart defects undergoing cardiopulmonary bypass
Pediatric Anesthesia, EarlyView.
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Association between children's emotional/behavioral problems before adenotonsillectomy and postoperative pain scores at home
Pediatric Anesthesia, EarlyView.
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Presaccadic EEG activity predicts visual saliency in free‐viewing contour integration
Psychophysiology, EarlyView.
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ERP correlates of valence asymmetry during incentive anticipation
Psychophysiology, EarlyView.
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For distinguished contributions to psychophysiology: Margaret M. Bradley
Psychophysiology, EarlyView.
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Identity and expression processing during classical conditioning with faces
Psychophysiology, EarlyView.
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Efficacy and safety of tenofovir in preventing mother-to-infant transmission of hepatitis B virus: A meta-analysis based on 6 studies from China and 3 studies from other countries
BMC Gastroenterology
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Case of reduction en masse who presented with no symptoms
Asian Journal of Endoscopic Surgery, EarlyView.
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Issue Information
Asian Journal of Endoscopic Surgery, Volume 11, Issue 3, Page 193-198, August 2018.
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Our connection procedure for an EEA™ XL stapler and anvil head using EEA OrVil™ for laparoscopic total or proximal gastrectomy
Asian Journal of Endoscopic Surgery, Volume 11, Issue 3, Page 280-283, August 2018.
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Epac1 deficiency inhibits basic fibroblast growth factor-mediated vascular smooth muscle cell migration
Abstract
Vascular smooth muscle cell (VSMC) migration and the subsequent intimal thickening play roles in vascular restenosis. We previously reported that an exchange protein activated by cAMP 1 (Epac1) promotes platelet-derived growth factor (PDGF)-induced VSMC migration and intimal thickening. Because basic fibroblast growth factor (bFGF) also plays a pivotal role in restenosis, we examined whether Epac1 was involved in bFGF-mediated VSMC migration. bFGF-induced lamellipodia formation and migration were significantly decreased in VSMCs obtained from Epac1−/− mice compared to those in Epac1+/+-VSMCs. The bFGF-induced phosphorylation of Akt and glycogen synthase kinase 3β (GSK3β), which play a role in bFGF-induced cell migration, was attenuated in Epac1−/−-VSMCs. Intimal thickening induced by the insertion of a large wire was attenuated in Epac1−/− mice, and was accompanied by the decreased phosphorylation of GSK3β. These data suggest that Epac1 deficiency attenuates bFGF-induced VSMC migration, possibly via Akt/GSK3β pathways.
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Mutations in WDR4 as a new cause of Galloway–Mowat syndrome
American Journal of Medical Genetics Part A, EarlyView.
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1q24 deletion syndrome. Two cases and new insights into genotype‐phenotype correlations
American Journal of Medical Genetics Part A, EarlyView.
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Dual diagnoses in 152 patients with Turner syndrome: Knowledge of the second condition may lead to modification of treatment and/or surveillance
American Journal of Medical Genetics Part A, EarlyView.
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An Additional Individual with a De Novo Variant in Myelin Regulatory Factor (MYRF) with Cardiac and Urogenital Anomalies: Further Proof of Causality: Comments on the article by Pinz et al. ()
American Journal of Medical Genetics Part A, EarlyView.
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Growth in achondroplasia: Development of height, weight, head circumference, and body mass index in a European cohort
American Journal of Medical Genetics Part A, EarlyView.
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Mucopolysaccharidosis III in Taiwan: Natural history, clinical and molecular characteristics of 28 patients diagnosed during a 21‐year period
American Journal of Medical Genetics Part A, EarlyView.
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Epidemiology of anophthalmia and microphthalmia: Prevalence and patterns in Texas, 1999–2009
American Journal of Medical Genetics Part A, EarlyView.
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Femoral‐facial syndrome: A review of the literature and 14 additional patients including a monozygotic discordant twin pair
American Journal of Medical Genetics Part A, EarlyView.
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Behavioral and psychological features in girls and women with triple‐X syndrome
American Journal of Medical Genetics Part A, EarlyView.
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Possible Congenital Zika Syndrome in Older Children Due to Earlier Circulation of Zika Virus
American Journal of Medical Genetics Part A, EarlyView.
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Studying Down syndrome recognition probabilities in Thai children with de‐identified computer‐aided facial analysis
American Journal of Medical Genetics Part A, EarlyView.
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Characterization of a severe case of PIK3CA‐related overgrowth at autopsy by droplet digital polymerase chain reaction and report of PIK3CA sequencing in 22 patients
American Journal of Medical Genetics Part A, EarlyView.
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Cole‐Carpenter syndrome in a patient from Thailand
American Journal of Medical Genetics Part A, EarlyView.
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Further delineation of spondyloepimetaphyseal dysplasia Faden‐Alkuraya type: A RSPRY1‐associated spondylo‐epi‐metaphyseal dysplasia with cono‐brachydactyly and craniosynostosis
American Journal of Medical Genetics Part A, EarlyView.
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Change in Prevalence of Orofacial Clefts in California between 1987 and 2010
American Journal of Medical Genetics Part A, EarlyView.
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Pulmonary hypertension in patients with 9q34.3 microdeletion‐associated Kleefstra syndrome
American Journal of Medical Genetics Part A, EarlyView.
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Mitral valve prolapse and aortic root dilation in adults with hypermobile Ehlers–Danlos syndrome and related disorders
American Journal of Medical Genetics Part A, EarlyView.
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Spinal dorsal horn astrocytes release GABA in response to synaptic activation
The Journal of Physiology, Volume 0, Issue ja, -Not available-.
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Blocking slow exocytosis with slow Ca2+ buffers slows recovery from depression
The Journal of Physiology, Volume 0, Issue ja, -Not available-.
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A simple decision to move in response to touch reveals basic sensory memory and mechanisms for variable response times
The Journal of Physiology, Volume 0, Issue ja, -Not available-.
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Multisensory activation of ventral cochlear nucleus D‐stellate cells modulates dorsal cochlear nucleus principal‐cell spatial coding
The Journal of Physiology, Volume 0, Issue ja, -Not available-.
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Short‐chain fatty acids: microbial metabolites that alleviate stress‐induced brain‐gut axis alterations
The Journal of Physiology, Volume 0, Issue ja, -Not available-.
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Advances in cellular and integrative control of oxygen and carbon dioxide homeostasis
The Journal of Physiology, Volume 596, Issue 15, Page 2933-2934, 1 August 2018.
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Issue Information
The Journal of Physiology, Volume 596, Issue 15, Page 2931-2932, 1 August 2018.
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Long‐term pulmonary vascular consequences of perinatal insults
The Journal of Physiology, Volume 0, Issue ja, -Not available-.
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Hepatic mitochondrial adaptations to physical activity: impact of sexual dimorphism, PGC1α, and BNIP3 mediated mitophagy
The Journal of Physiology, Volume 0, Issue ja, -Not available-.
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Preconditioning contractions prevent the delayed onset of myofibrillar dysfunction after damaging eccentric contractions
The Journal of Physiology, Volume 0, Issue ja, -Not available-.
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MRs‐Redox Signaling Contributes to Renal Tubular Cell Epithelial‐Mesenchymal Transition and Fibrosis and Inflammation of the Kidneys
The Journal of Physiology, Volume 0, Issue ja, -Not available-.
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Renewed Excitement for Paraventricular Neurons and Sympathetic Nerve Activity
The Journal of Physiology, Volume 0, Issue ja, -Not available-.
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PREVIOUS COLONIC RESECTION IS A RISK FACTOR FOR SURGICAL RELAPSE IN CROHN’S DISEASE
Despite the improvement of medical therapies, nearly half of patients with Crohn's disease require surgery within 10 years after diagnosis. However, intestinal resection is not curative and recurrence may occur.
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Is there a link between periampullary diverticula and biliopancreatic disease? An EUS approach to answer the question
Many studies, almost all in an Endoscopic Retrograde Cholangiopancreatography (ERCP) setting, have been conducted to establish if a link exists between periampullary diverticula (PADs) and biliopancreatic diseases but the issue is still debated.
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Age-related attenuation of conduit artery blood flow response to passive heating differs between the arm and leg
Abstract
Purpose
Little is known about why the attenuation of heat loss responses with aging begins in the lower limbs. This study sought to determine whether passive heating causes the age-related decrease and limb-specific difference of blood flow (BF) responses between conduit brachial and femoral arteries, which are related to differences of cutaneous vascular conductance (CVC) between the upper and lower limbs.
Method
In 15 older and 12 younger males, BF in the brachial and femoral arteries was ultrasonically measured and CVC in the forearm and thigh was assessed during lower leg immersion in hot water at 42 °C (ambient temperature: 30 °C, relative humidity: 45%) for 40 min.
Results
The increased BF of brachial artery at the end of passive heating was similar between both age groups (older: 140 ± 4%; younger: 146 ± 11%), while that of femoral artery was smaller in older than younger group (119 ± 4% vs. 166 ± 11%, P < 0.01). Moreover, the increased CVC in the forearm was similar between the age groups (older: 356 ± 50%; younger: 308 ± 46%), although CVC in the thigh was significantly lower in older than younger group (303 ± 33% vs. 427 ± 51%, P < 0.05). These results corresponded to the BF responses of the brachial and femoral arteries, respectively.
Conclusion
These results indicate that age-related decrease and limb-specific difference occur also in conduit arteries of arm and leg, which might be related to the different reduction in CVC between forearm and thigh.
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PREVIOUS COLONIC RESECTION IS A RISK FACTOR FOR SURGICAL RELAPSE IN CROHN’S DISEASE
Despite the improvement of medical therapies, nearly half of patients with Crohn's disease require surgery within 10 years after diagnosis. However, intestinal resection is not curative and recurrence may occur.
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Is there a link between periampullary diverticula and biliopancreatic disease? An EUS approach to answer the question
Many studies, almost all in an Endoscopic Retrograde Cholangiopancreatography (ERCP) setting, have been conducted to establish if a link exists between periampullary diverticula (PADs) and biliopancreatic diseases but the issue is still debated.
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Post-Transplant Disease Recurrence in Pediatric PSC
Abstract
Purpose of Review
Review the current knowledge about recurrent primary sclerosing cholangitis (rPSC) after transplant in children.
Recent Findings
Recurrent PSC is a significant complication that afflicts 16% of children after liver transplantation for primary sclerosing cholangitis (PSC) at a median onset of 38 months post-transplant. Possible risk factors include younger age at PSC diagnosis or transplant, the presence of overlap syndrome or IBD, and post-transplant induction with thymoglobulin. rPSC impairs the patient's quality of life and can be detrimental to the graft. Preventive options and therapeutic measures are limited. Ursodeoxycholic acid is widely used, but its effect on long-term outcome is unknown. Vancomycin can improve the biochemical profile of rPSC, but it remains unknown whether it halts the disease progression.
Summary
Pediatric liver transplant for primary sclerosis cholangitis can be complicated by recurrence of the disease, which portends poor outcomes. Although few risk factors have been implicated, larger studies with longer follow-ups are needed to characterize cardinal risk factors for rPSC, as well as evaluate possible preventative and therapeutic options.
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