Κυριακή 30 Οκτωβρίου 2016
Loss-of-function genetic tools for animal models: cross-species and cross-platform differences
Loss-of-function (LOF) approaches are powerful experimental tools for characterizing gene functions. However, emerging discrepancies when genes are investigated using different tools or organisms has triggered debate about how such LOF results should be biologically interpreted. In this Review, experts from varied fields discuss how understanding the underlying features of each LOF approach can provide explanations for different experimental outcomes and can guide their optimal and reliable application.
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A network-biology perspective of microRNA function and dysfunction in cancer
MicroRNAs (miRNAs) have emerged as crucial components of gene-regulatory networks, in which they act alone or cooperatively to regulate gene expression. Here, the authors provide a systems-biological view of miRNA function and how disruption of miRNA networks can lead to malignancy.
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Robotic quantification of upper extremity loss of independent joint control or flexion synergy in individuals with hemiparetic stroke: a review of paradigms addressing the effects of shoulder abduction loading
Unsupported or "against-gravity" reaching and hand opening movements are greatly impaired in individuals with hemiparetic stroke. The reduction in reaching excursion and hand opening is thought to be primarily...
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