Publication date: Available online 9 December 2016
Source:Arab Journal of Gastroenterology
Author(s): Aya Hammami, Aida Ben Slama, Hanen Jaziri, Wafa Ben Ameur, Imed Ben Mansour, Ahlem Brahem, Salem Ajmi, Hela Jemni, Mehdi Ksiaa, Ali Jmaa
Crohn's disease (CD) is characterized by transmural inflammation of the gastrointestinal tract, which predisposes to the formation of fistula. Duodenal involvement occurs in less than 5% of cases and often leads to clinically relevant strictures. However, fistula formation in the duodenum is exceptional. Herein, we report an unusual case of duodenobiliary fistula due to CD occurring in a 65-year-old patient who was successfully treated by anti-tumor necrosis factor (TNF) agents. This case report highlights the efficacy of anti-TNF alpha agents in the treatment of a bilioenteric fistula because it increases the probability of clinical remission and mucosal healing and therefore reduces the need for surgical treatment which may be associated morbidity.
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2gn3Rbx
via IFTTT
Παρασκευή 9 Δεκεμβρίου 2016
Unusual case of duodenobiliary fistula complicating Crohn’s disease successfully treated with Adalimumab
NF-Y in cancer: Impact on cell transformation of a gene essential for proliferation
Publication date: Available online 9 December 2016
Source:Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Author(s): Aymone Gurtner, Isabella Manni, Giulia Piaggio
NF-Y is a ubiquitous heterotrimeric transcription factor with a binding affinity for the CCAAT consensus motif, one of the most common cis-acting element in the promoter and enhancer regions of eukaryote genes in direct (CCAAT) or reverse (ATTGG) orientation. NF-Y consists of three subunits, NF-YA, the regulatory subunit of the trimer, NF-YB, and NF-YC, all required for CCAAT binding. Growing evidence in cells and animal models support the notion that NF-Y, driving transcription of a plethora of cell cycle regulatory genes, is a key player in the regulation of proliferation. Proper control of cellular growth is critical for cancer prevention and uncontrolled proliferation is a hallmark of cancer cells. Indeed, during cell transformation aberrant molecular pathways disrupt mechanisms controlling proliferation and many growth regulatory genes are altered in tumors. Here, we review bioinformatics, molecular and functional evidence indicating the involvement of the cell cycle regulator NF-Y in cancer-associated pathways. This article is part of a Special Issue entitled: Nuclear Factor Y in Development and Disease, edited by Prof. Roberto Mantovani.
from Genetics via xlomafota13 on Inoreader http://ift.tt/2guPq3w
via IFTTT
Vestibular implants studied in animal models: clinical and scientific implications
Damage to the peripheral vestibular system can result in debilitating postural, perceptual, and visual symptoms. A potential new treatment for this clinical problem is to replace some aspects of peripheral vestibular function with an implant that senses head motion and provides this information to the brain by stimulating branches of the vestibular nerve. In this review I consider animal studies performed at our institution over the past 15 years, which have helped elucidate how the brain processes information provided by a vestibular (semicircular canal) implant and how this information could be used to improve the problems experienced by patients with peripheral vestibular damage.
from Physiology via xlomafota13 on Inoreader http://ift.tt/2hw82hf
via IFTTT
Driving After Adolescent Concussion: Advice From Nurse Practitioners in the Absence of Standardized Recommendations
Nurse practitioners (NPs) are authorized to manage concussion recovery. Common adolescent activities, like driving, are omitted from guidelines. We investigated NP driving guidance and its clinical basis for restriction or limitation following adolescent concussion.
from Health via xlomafota13 on Inoreader http://ift.tt/2hdCjSO
via IFTTT
Asthma Home Management in the Inner-City: What can the Children Teach us?
Knowledge of asthma home management from the perspective of poor, minority children with asthma is limited.
from Health via xlomafota13 on Inoreader http://ift.tt/2guwn9J
via IFTTT
Rickets: Not Just a Disease Caused by Vitamin D Deficiency
A 2-year, 10-month-old White girl presented to a pediatric clinic with an abnormal wide gait and genu varum. She had been an established patient at the clinic since her 4-month well-child visit. Concerns regarding her motor development were noted at her 6-month well-child visit, when she presented with generalized muscle hypotonia, was unable to roll supine to prone or prone to supine, and was unable to sit unassisted. Additionally, the patient had dropped to the 5th to 10th percentile for weight at 6 months from the 25th percentile at her 4-month visit.
from Health via xlomafota13 on Inoreader http://ift.tt/2hdxRmU
via IFTTT
Authors’ Reply to Anoop Balachandran et al.: Comment on “Sub-Anesthetic Xenon Increases Erythropoietin Levels in Humans: A Randomized Controlled Trial”
Neural control and precision of flight muscle activation in Drosophila
Abstract
Precision of motor commands is highly relevant in a large context of various locomotor behaviors, including stabilization of body posture, heading control and directed escape responses. While posture stability and heading control in walking and swimming animals benefit from high friction via ground reaction forces and elevated viscosity of water, respectively, flying animals have to cope with comparatively little aerodynamic friction on body and wings. Although low frictional damping in flight is the key to the extraordinary aerial performance and agility of flying birds, bats and insects, it challenges these animals with extraordinary demands on sensory integration and motor precision. Our review focuses on the dynamic precision with which Drosophila activates its flight muscular system during maneuvering flight, considering relevant studies on neural and muscular mechanisms of thoracic propulsion. In particular, we tackle the precision with which flies adjust power output of asynchronous power muscles and synchronous flight control muscles by monitoring muscle calcium and spike timing within the stroke cycle. A substantial proportion of the review is engaged in the significance of visual and proprioceptive feedback loops for wing motion control including sensory integration at the cellular level. We highlight that sensory feedback is the basis for precise heading control and body stability in flies.
from Physiology via xlomafota13 on Inoreader http://ift.tt/2h75QQd
via IFTTT
Extradural Hematoma With Unanticipated Difficult Intubation Due to Rhinoscleromatosis
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2gtVgSE
via IFTTT
JNA Journal Club
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2hcYY1h
via IFTTT
Equiosmolar Solutions of Hypertonic Saline and Mannitol Do Not Impair Blood Coagulation During Elective Intracranial Surgery
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2hd6NEu
via IFTTT
Regional Anesthesia for Craniotomy
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2gu2ciU
via IFTTT
Comparison of Intra-Abdominal Pressure Among 3 Prone Positional Apparatuses After Changing From the Supine to the Prone Position and Applying Positive End-Expiratory Pressure in Healthy Euvolemic Patients: A Prospective Observational Study
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2gtYYvJ
via IFTTT
Comparison of Continuous Noninvasive Blood Pressure Monitoring by TL-300 With Standard Invasive Blood Pressure Measurement in Patients Undergoing Elective Neurosurgery
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2gtYIN4
via IFTTT
Association Between Perioperative Hyperglycemia and Survival in Patients With Glioblastoma
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2gu52UX
via IFTTT
Comparing the Intubation Performance of Macintosh and Airtraq Laryngoscopes
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2hd2oBw
via IFTTT
Intraoperative Monitoring of Diaphragm Neural Pathways During Cervical Surgery by Electrical Stimulation and Recordings of Ventilator Waveforms: Physiological Bases and Pilot Study
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2hd2sAV
via IFTTT
The Power of Raw Data
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2hd1iFN
via IFTTT
Sevoflurane Postconditioning Reduces Apoptosis by Activating the JAK-STAT Pathway After Transient Global Cerebral Ischemia in Rats
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2hd3ywK
via IFTTT
Handbook of Bleeding and Coagulation in Neurosurgery
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2gtVfhy
via IFTTT
A Dexamethasone-regulated Gene Signature Is Prognostic for Poor Survival in Glioblastoma Patients
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2gtXsd4
via IFTTT
The Effect of Increased Intracranial Pressure on Pulmonary Compliance in a Neonate
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2gu22bl
via IFTTT
The Effects of Handed Bias of Physicians and the Laterality of Recumbent Position of Patients on the Success Rate of Lumbar Puncture
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2gtToto
via IFTTT
Reply
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2hd2pVO
via IFTTT
ILMA as an Alternative to Face Mask Ventilation in a Case of Nasal Chondrosarcoma
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2hcWqQV
via IFTTT
Intubation Difficulty Scale Score and Videolaryngoscopes
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2gu0kGJ
via IFTTT
Hyperventilation, Sympathetic and Metabolic Derangements After Endoscopic Third Ventriculostomy
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2hd1QeI
via IFTTT
Regional Anesthesia to the Scalp for Craniotomy: Innovation With Innervation
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2gtXp0S
via IFTTT
Carcinoembryonic Antigen Level in Primary Sclerosing Cholangitis Is Not Influenced by Dominant Strictures or Bacterial Cholangitis
Abstract
Background
Carcinoembryonic antigen (CEA) can be used to screen for biliary tract cancer in patients with primary sclerosing cholangitis (PSC).
Aim
To study the influence of benign dominant strictures (DS), superimposed bacterial cholangitis (SBC), smoking status, and inflammatory bowel disease on CEA serum levels.
Methods
A retrospective analysis of CEA values in cancer-free PSC patients was performed. We included the maximal CEA value obtained during follow-up and information on the presence of DS and SBC at that time, and we analyzed the CEA values in the presence and absence of DS and SBC. Results are reported as medians with the interquartile range (IQR).
Results
The median maximal CEA level, which was 1.8 ng/mL (IQR 1.2–2.9) in the final 270 PSC patients included in the study, was not influenced by the presence of either DS or SBC (P = 0.320). Moreover, in 49 patients, the first CEA value available at the time of DS (1.5 ng/mL; IQR 1.2–2.1) and that at a time without DS (1.6 ng/mL; IQR 1.1–2.3) did not differ significantly (P = 0.397). Lastly, in 24 patients, the median CEA values at a time without SBC (1.8 ng/mL; IQR 1.2–2.5) and at the time of SBC (1.8 ng/mL; IQR 1.0–3.0) were comparable (P = 0.305). Smoking did not influence CEA-based cancer screening.
Conclusions
Serum CEA level is not influenced by the presence of DS or SBC and might therefore serve as a favorable parameter for improving cancer screening in PSC patients.
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2huBGU5
via IFTTT
From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative “Superbugs” Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators
Microbial Drug Resistance , Vol. 0, No. 0.
from Mary Ann Liebert, Inc. publishers via xlomafota13 on Inoreader http://ift.tt/2hfI42x
via IFTTT
Effect of tempol and tempol plus catalase on intra-renal haemodynamics in spontaneously hypertensive stroke-prone (SHSP) and Wistar rats
Abstract
Vasoconstriction within the renal medulla contributes to the development of hypertension. This study investigated the role of reactive oxygen species (ROS) in regulating renal medullary and cortical blood perfusion (MBP and CBP respectively) in both stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar rats. CBP and MBP were measured using a laser-Doppler flow meter before and after intra-renal infusion of tempol, the superoxide dismutase (SOD) mimetic or tempol plus catalase, the hydrogen peroxide-degrading enzyme. Tempol infusion significantly elevated blood perfusion within the renal medulla (MBP) in both SHRSP (by 43 ± 7%, P < 0.001) and Wistar rats (by 17 ± 2%, P < 0.05) but the magnitude of the increase was significantly greater in the SHRSP (P < 0.01). When the enzyme catalase and tempol were co-infused, MBP was again significantly increased in SHRSP (by 57 ± 6%, P < 0.001) and Wistar rats (by 33 ± 6%, P < 0.001), with a significantly greater increase in perfusion being induced in the SHRSP relative to the Wistar rats (P < 0.01). Notably, this increase was significantly greater than in those animals infused with tempol alone (P < 0.01). These results suggest that ROS plays a proportionally greater role in reducing renal vascular compliance, particularly within the renal medulla, in normotensive and hypertensive animals, with effects being greater in the hypertensive animals. This supports the hypothesis that SHRSP renal vasculature might be subjected to elevated level of oxidative stress relative to normotensive animals.
from Physiology via xlomafota13 on Inoreader http://ift.tt/2hlSGQo
via IFTTT
Safe Life Defense Body Armor (Bulletproof vest)
Visit Safe Life Defense and The Guardian Angel Program on Indiegogo at http://ift.tt/2hdrEdI Sales, rewards, discounts and more! For every $400 collectively contributed we will donate a vest through the Guardian Angel Program! Together we make a difference.
from EMS via xlomafota13 on Inoreader http://ift.tt/2gjcgba
via IFTTT
1 hurt in San Diego ambulance, trolley collision
The ambulance was responding to a call and had its lights and sirens activated when the crash occurred
from EMS via xlomafota13 on Inoreader http://ift.tt/2hnCNJc
via IFTTT
Calif. off-duty paramedic, nurse aid man hit by car
By EMS1 Staff
SAN DIEGO — An off-duty and paramedic came to the aid of a man who was struck by a car Thursday.
The man was walking on a busy freeway when he was struck by a vehicle, who was then rear-ended by a second vehicle. Officials said it is unclear why the man was in the road.
A nurse and his wife, a paramedic, pulled over to render aid.
"My wife saw a body in the road, so we pulled up a little closer. We saw a guy sitting up and he had a bunch of injuries going on, bleeding," Biran San Miguel, a nurse, told FOX5.
The man suffered moderate injuries and was transported to the hospital. There were no other reported injuries.
Nurse, paramedic stop to help man hit by car on freeway https://t.co/Xl8y8zxu0R http://pic.twitter.com/OetBmTDeQZ
— Gaby's Trump (@gabyramirez078) December 9, 2016
from EMS via xlomafota13 on Inoreader http://ift.tt/2hfscgE
via IFTTT
Safe Life Defense Body Armor (Bulletproof vest)
Visit Safe Life Defense and The Guardian Angel Program on Indiegogo at http://ift.tt/2hdrEdI Sales, rewards, discounts and more! For every $400 collectively contributed we will donate a vest through the Guardian Angel Program! Together we make a difference.
from EMS via xlomafota13 on Inoreader http://ift.tt/2gjcgba
via IFTTT
Safe Life Defense Body Armor President Getting Hit with a Baseball Bat!
Bullets and knives aren't the only threats. Thats why we've integrated strike resistance into our body armor! Strike Resistance, only by Safe Life Defense.
from EMS via xlomafota13 on Inoreader http://ift.tt/2gJunrJ
via IFTTT
Safe Life Defense Body Armor (Bulletproof vest)
Visit Safe Life Defense and The Guardian Angel Program on Indiegogo at http://ift.tt/2hdrEdI Sales, rewards, discounts and more! For every $400 collectively contributed we will donate a vest through the Guardian Angel Program! Together we make a difference.
from EMS via xlomafota13 on Inoreader http://ift.tt/2gjcgba
via IFTTT
Safe Life Defense Body Armor President Getting Hit with a Baseball Bat!
Bullets and knives aren't the only threats. Thats why we've integrated strike resistance into our body armor! Strike Resistance, only by Safe Life Defense.
from EMS via xlomafota13 on Inoreader http://ift.tt/2gJunrJ
via IFTTT
Safe Life Defense Body Armor (Bulletproof vest)
Visit Safe Life Defense and The Guardian Angel Program on Indiegogo at http://ift.tt/2hdrEdI Sales, rewards, discounts and more! For every $400 collectively contributed we will donate a vest through the Guardian Angel Program! Together we make a difference.
from EMS via xlomafota13 on Inoreader http://ift.tt/2gjcgba
via IFTTT
Safe Life Defense Body Armor President Getting Hit with a Baseball Bat!
Bullets and knives aren't the only threats. Thats why we've integrated strike resistance into our body armor! Strike Resistance, only by Safe Life Defense.
from EMS via xlomafota13 on Inoreader http://ift.tt/2gJunrJ
via IFTTT
Quality of nurse patient therapeutic communication and overall patient satisfaction during their hospitalization stay
2016-12-09T08-55-28Z
Source: International Journal of Medical Science and Public Health
Sandhya Negi, Harleen Kaur, Grace M Singh.
Background: Effective communication is very important aspect in a nursing career. When patient admitted in the ward then therapeutic nurse patient relationship developed and if person is not mentally disturbed so that is very important nurses will properly communicate or needs to show a greater amount of interest to the information-giving process and decision making regarding the care of the patient. Objectives: The main aim of the research is to find the quality of nurse patient therapeutic communication and overall patient satisfaction during their hospitalization stay. Material and Method: An exploratory descriptive design was followed. A total of 110 patients were recruited by convenient sampling technique. Self developed Likert scale is used to assess the quality of nurse patient therapeutic communication and patient satisfaction. Result: Finding suggests that the most (81.8%) of the patient agreed that nurse was helpful and should concern on them, and 81% of the patient agreed that privacy and confidentiality was maintained. Only a few patients (4.5%) agreed that nurses were prompt in decision-making regarding their care.
from Scope via xlomafota13 on Inoreader http://ift.tt/2hf13dS
via IFTTT
Safe Life Defense Body Armor President Getting Hit with a Baseball Bat!
Bullets and knives aren't the only threats. Thats why we've integrated strike resistance into our body armor! Strike Resistance, only by Safe Life Defense.
from EMS via xlomafota13 on Inoreader http://ift.tt/2gJunrJ
via IFTTT
New KIMTEK Website Targets Brush Truck Market
ORLEANS, Vt. — KIMTEK Corporation, the world leader in off-road fire rescue skid units for UTV side-by-sides and pick-up and flatbed trucks, has announced the launch of its new website dedicated to the needs of firefighting agencies using pick-ups and flatbed trucks for off-road wildland firefighting. The new website, http://ift.tt/2hbTDHC, can be accessed directly or linked via the company's ...
from EMS via xlomafota13 on Inoreader http://ift.tt/2gsJqIH
via IFTTT
NAPNAP Position Statement on the Doctor of Nursing Practice (DNP)
The National Association of Pediatric Nurse Practitioners (NAPNAP) endorses the Doctor of Nursing Practice (DNP) degree as the appropriate credential and a terminal level of education for advanced practice nurses. NAPNAP has consistently led the way in advancing the role of the pediatric nurse practitioner (PNP) by advocating for high-quality education.
from Health via xlomafota13 on Inoreader http://ift.tt/2hbXNlA
via IFTTT
A Novel Approach for the Control of Inflammatory Pain: Prostaglandin E2 Complexation by Randomly Methylated [beta]-Cyclodextrins.
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2hs0lIS
via IFTTT