Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection: Background. Changes of hepatitis B core antigen antibody (anti-HBc) in liver pathological involvement in patients with chronic hepatitis B virus (HBV) infection have not been investigated in detail. This study aimed to explore evolving patterns of anti-HBc following liver pathological states and to investigate validities of anti-HBc for predicting liver pathological states. Methods. 254 HBeAg-positive...
09:31
A Case of Long-Term Survival after Checkpoint Inhibitor Pneumonitis in a Patient with Squamous Cell Lung Cancer: The management of grade 1 checkpoint inhibitor pneumonitis (CIP) is to withhold immune checkpoint inhibitors; however, the natural history of this condition is unknown. We herein report the case of a woman with squamous cell lung cancer who was a long-term survivor after CIP. After 4 rounds of treatment with nivolumab, a chest CT revealed a reticular pattern and ground-glass attenuation...
09:31
The Impact of Physicians' Working Hours on Inappropriate Use of Outpatient Medicine in a Tertiary Hospital in China: AbstractBackgroundInappropriate prescribing is an important health system problem in China. Several studies have identified critical factors influencing prescription quality, but the impact of physicians' working hours remains unknown. In China, tertiary hospitals face ever-increasing outpatient volumes. Physicians are asked to work long hours and the impact of shift duration on prescription...
09:31
iFuse Implant System for Treating Chronic Sacroiliac Joint Pain: A NICE Medical Technology Guidance: AbstractTreatment and management of sacroiliac joint pain is often non-surgical, involving packages of care that can include analgesics, physiotherapy, corticosteroid injections and radiofrequency ablation. Surgical intervention is considered when patients no longer respond to conservative management. The iFuse Implant System is placed across the sacroiliac joint using minimally invasive surgery,...
09:30
Emerging Use of Ultra-High-Field 7T MRI in the Study of Intracranial Vascularity: State of the Field and Future Directions [REVIEW ARTICLE]: SUMMARY:Cerebrovascular disease is a major source of mortality that commonly requires neurosurgical intervention. MR imaging is the preferred technique for imaging cerebrovascular structures, as well as regions of pathology that include microbleeds and ischemia. Advanced MR imaging sequences such as time-of-flight, susceptibility-weighted imaging, and 3D T2-weighted...
09:30
Intra-Arterial Verapamil Treatment in Oral Therapy-Refractory Reversible Cerebral Vasoconstriction Syndrome [INTERVENTIONAL]: SUMMARY:Reversible vasoconstriction syndrome is a complex of clinical symptoms and angiographic findings, which, while having a mostly benign clinical course, has clinical and imaging overlap with more serious disorders such as vasculitis and aneurysmal SAH and itself includes a minority of patients with fulminant vasoconstriction resulting in severe intracranial complications....
09:29
Metal Artifact Reduction in Head CT Performed for Patients with Deep Brain Stimulation Devices: Effectiveness of a Single-Energy Metal Artifact Reduction Algorithm [ADULT BRAIN]: BACKGROUND AND PURPOSE:Deep brain stimulation electrodes induce massive artifacts on CT images, deteriorating the diagnostic value of examinations. We aimed to investigate the usefulness and potential limitations of a single-energy metal artifact reduction algorithm in head CT performed in patients with implanted deep brain...
09:29
Characterization of Carotid Plaque Components by Quantitative Susceptibility Mapping [EXTRACRANIAL VASCULAR]: BACKGROUND AND PURPOSE:Intraplaque hemorrhage in the carotid artery is related to an increased risk of cerebrovascular ischemic events. We aimed to investigate whether quantitative susceptibility mapping can characterize carotid artery plaque components and quantify the severity of intraplaque hemorrhage.MATERIALS AND METHODS:For this ex vivo quantitative susceptibility mapping study, 9 carotid...
09:29
The use and cost‐effectiveness of intraoperative navigation in pediatric sinus surgery: Objectives/HypothesisThere are consensus statements about when to use intraoperative navigation (IN) in adult sinus surgery. However, no corresponding guidelines exist for pediatrics. Our objectives included: 1) assess the demographic and operative factors associated with IN use and 2) calculate the cost‐effectiveness of IN use.Study DesignRetrospective chart review.MethodsOne hundred nineteen pediatric patients...
09:28
Relationship of Overall Cardiovascular Health and Hearing Loss in The Jackson Heart Study Population
Relationship of Overall Cardiovascular Health and Hearing Loss in The Jackson Heart Study Population: ObjectivesTo evaluate the relationships among the overall cardiovascular health scoring tool, Life's Simple 7 (LS7), and hearing in an African‐American cardiovascular study cohort.MethodsUsing the Jackson Heart Study's cohort of African Americans, the relationships between the LS7 scoring metric and hearing of 1314 individuals were assessed. Standard audiometric data was collected and hearing loss...
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Does 3D volumetric analysis predict the reach of endoscopically harvested buccal fat pad flap: ObjectivesTo determine if the volume of buccal fat, ascertained by computed tomography (CT) scanning, would correspond to surface area and reach (length and width) of the flap intraoperatively to aid in the reconstruction of selected skull base defects.MethodsCadaveric study of five specimens, 10 sides. Methods CT imaging and evaluation using the Osirix 9 software (Pixmeo; Bernex, Switzerland). of cadaveric...
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Age-Related Hyperglycemia as a Cause of Increased Cancer Incidence: Why is cancer an age-related condition? One can propose a range of mechanisms: the spread of stochastic DNA damage through cell populations; rising levels of chronic inflammation; ever more senescent cells turning out disruptive, pro-growth signals; the growing inability of the immune system to promptly destroy errant cells. The authors of this open access paper argue that the metabolic dysfunction of later life that leads to raised...
09:27
Eosinophilic esophagitis: A new food-related allergic condition on the rise?: In the early 1990s, doctors began describing a new condition affecting the esophagus of patients who were predisposed to allergies including food allergy, asthma, and eczema, and who were having trouble swallowing. Today, we call this condition eosinophilic esophagitis (EoE). What is EoE? EoE is an allergic inflammation of the esophagus that causes a range of symptoms. Adolescents and adults most often experience it as...
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Surgical tracheostomy in children with malignancy receiving intensive chemotherapy: A case series and review of literature: AbstractWe retrospectively reviewed a paediatric intensive care unit database that supports a tertiary oncology service to explore safety and outcome of tracheostomy in oncology patients over a 12‐year period and reviewed literature. A total of 895 patients were admitted with a haematological or a solid tumour malignancy of which 222 were ventilated. Six of 222 (2.7%) ventilated...
09:26
Thermal ablation for hepatocellular carcinoma: what's new in 2019: Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide, but a major proportion of patients are not appropriate candidates for surgical resection or transplantation. For this reason, image-guided tumor ablation using thermal energy for early-stage HCC has become an accepted curative treatment option in all HCC treatment guidelines due to its minimal invasiveness and proven outcomes. In recent years, microwave ablation...
09:26
Mucoid and coccoid Helicobacter pylori with fast growth and antibiotic resistance: AbstractBackgroundIn this study, one Helicobacter pylori isolate, from gastric biopsy of a dyspeptic patient that turned into mucoid‐coccoid (MC) form upon consecutive subcultures, was identified. The culturability, antibiotic resistance, and lipid contents of MC were compared with those of non‐mucoid (NM) spiral H pylori.Materials and MethodsMucoid‐coccoid and NM H pylori were subcultured on Brucella blood agar (BBA)...
09:26
BCOR‐CCNB3 fusion‐positive clear cell sarcoma of the kidney: AbstractClear cell sarcoma of the kidney (CCSK) is the second most common malignant pediatric renal tumor. Two of the recurrent somatic alterations reported in CCSK are BCL‐6 corepressor (BCOR) internal tandem duplication (ITD) and YWHAE‐NUTM2B/E gene fusion. A minority of patients with CCSKs have other rare somatic alterations. We report two patients with CCSK showing BCOR‐CCNB3 (where CCNB3 is cyclin B3) fusion, who had similar clinical...
09:26
The effect of graft‐versus‐host disease on outcomes after allogeneic stem cell transplantation for refractory lymphoblastic lymphoma in children and young adults: AbstractBackgroundPatients with relapsed or refractory lymphoblastic lymphoma (LBL) have a poor prognosis. The efficacy of allogeneic blood stem cell transplantation for treatment of this disease remains unclear in terms of transplantation‐related toxicity. Acute and chronic graft‐versus‐host diseases (GVHD) are both harmful to patients...
09:25
The Therapeutic Effect of Nordic Walking on Freezing of Gait in Parkinson's Disease: A Pilot Study: Introduction. The effectiveness of the currently utilized therapies for FoG is limited. Several studies demonstrated a beneficial impact of Nordic walking (NW) on several gait parameters in Parkinson's disease, but only one paper reported reduction of freezing. Research Question. In the present study, the question is whether NW is an effective therapeutic intervention in FoG. Methods. Twenty PD subjects...
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Incidental Anomalous Left Coronary Artery in a Transplanted Heart: Anomalous coronary artery is an uncommon congenital cardiac anomaly that is often detected incidentally on coronary angiography. It has rarely been reported in the donor heart of patients who have undergone cardiac transplantation. Here, we report a case of a 72-year-old patient who received a second heart transplant and has been identified to have an anomalous left main coronary artery originating from the right coronary sinus on...
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IJERPH, Vol. 17, Pages 189: Mapping the Human Exposome to Uncover the Causes of Breast Cancer: IJERPH, Vol. 17, Pages 189: Mapping the Human Exposome to Uncover the Causes of Breast CancerInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17010189Authors: Vincent Bessonneau Ruthann A. Rudel Breast cancer is an important cause of morbidity and mortality for women, yet a significant proportion of variation in individual risk is unexplained. It is reasonable to...
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Chronic Disseminated Candidiasis During Hematological Maligancies: An Immune Reconstitution Inflammatory Syndrome with Expansion of Pathogen-Specific TH1 T Cells: AbstractChronic disseminated candidiasis (CDC) is a rare disease mostly occurring after chemotherapy-induced prolonged neutropenia in patients with hematological malignancies. It is believed to ensue from Candida colonization, breach of the intestinal epithelial barrier and venous translocation to organs. Fungal blood or liver biopsy cultures...
09:18
Screening Strategies for a Sustainable Endpoint for Gambiense Sleeping Sickness: AbstractBackgroundGambiense human African trypanosomiasis ([gHAT] sleeping sickness) is a vector-borne disease that is typically fatal without treatment. Intensified, mainly medical-based, interventions in endemic areas have reduced the occurrence of gHAT to historically low levels. However, persistent regions, primarily in the Democratic Republic of Congo (DRC), remain a challenge to achieving the World Health Organization's...
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Development and application of a microplate assay for toxicity testing on aquatic cyanobacteria: AbstractRegulatory environmental risk assessment (ERA), applied to establish a protection limit for all bacterial diversity in surface waters, relies on a growth inhibition test performed upon a single species of cyanobacteria and the activated sludge respiration inhibition test (ASRIT). Recently, the ability of this approach to protect adequately for bacteria that provide important ecosystem services...
09:17
Chemical content and source apportionment of 36 heavy metal analysis and health risk assessment in aerosol of Beijing: AbstractThe concentration levels of 36 airborne heavy metals and atmospheric radioactivity in total suspended particulate (TSP) samples were measured to investigate the chemical characteristics, potential sources of aerosols, and health risk in Beijing, China, from September 2016 to September 2017. The TSP concentrations varied from 6.93 to 469.18 μg/m3, with a median of 133.97 μg/m3....
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Thin-layer fine-sand capping of polluted sediments decreases nutrients in overlying water of Wuhan Donghu Lake in China: AbstractCapping water body sediments with a thin layer of sand is an effective technique to decrease nutrient concentrations in the water column and accelerate ecological restoration of eutrophic water bodies. However, long-term effects of thin-layer sand capping in shallow lakes are reported less often. Using clean fine sand and geotextile mats as capping materials for sediments...
09:15
N 2 fixation in urbanization area rivers: spatial-temporal variations and influencing factors: AbstractWhile nitrogen (N2) fixation is an important process in nitrogen (N) biogeochemical cycling, supplying a significant portion of the N in natural ecosystems, few quantitative constraints exist concerning its contribution to the N enrichment and export from river ecosystems. This study estimates the N2 fixation rates of urban rivers in the Yangtze Estuary area using acetylene reduction. The results...
09:14
Cells, Vol. 9, Pages 70: Autophagy and Macrophage Functions: Inflammatory Response and Phagocytosis: Cells, Vol. 9, Pages 70: Autophagy and Macrophage Functions: Inflammatory Response and PhagocytosisCells doi: 10.3390/cells9010070Authors: Ming-Yue Wu Jia-Hong Lu Autophagy is a conserved bulk degradation and recycling process that plays important roles in multiple biological functions, including inflammatory responses. As an important component of the innate immune system, macrophages are involved...
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Growth charts in Kabuki syndrome 1: AbstractKabuki syndrome (KS, KS1: OMIM 147920 and KS2: OMIM 300867) is caused by pathogenic variations in KMT2D or KDM6A. KS is characterized by multiple congenital anomalies and neurodevelopmental disorders. Growth restriction is frequently reported. Here we aimed to create specific growth charts for individuals with KS1, identify parameters used for size prognosis and investigate the impact of growth hormone therapy on adult height. Growth parameters and parental...
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JCM, Vol. 9, Pages 71: Selective ß2-Adrenoceptor Agonists and Relevant Hyperlactatemia: Systematic Review and Meta-Analysis: JCM, Vol. 9, Pages 71: Selective ß2-Adrenoceptor Agonists and Relevant Hyperlactatemia: Systematic Review and Meta-AnalysisJournal of Clinical Medicine doi: 10.3390/jcm9010071Authors: Alina G. Liedtke Sebastiano A. G. Lava Gregorio P. Milani Carlo Agostoni Viola Gilardi Mario G. Bianchetti Giorgio Treglia Pietro B. Faré Selective ß2-agonists have been imputed...
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Efficacy of reciprocating and ultrasonic activation of 6% sodium hypochlorite in the reduction of microbial content and virulence factors in teeth with primary endodontic infection: AbstractAimTo evaluate in a clinical trial the efficacy of reciprocating and ultrasonic activation of 6% sodium hypochlorite (NaOCl) in microbial composition and reduction of microbial load as well as in levels of lipopolysaccharide (LPS) and lipoteichoic acid (LTA) in teeth with primary endodontic infection.MethodologySamples...
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Gaint Phyllodes Tumour with Axillary & Interpectoral Lymph Node Metastasis; a Rare Presentation: ConclusionManagement of Phyllodes tumor presents the surgeon with challenges. Core tissue biopsy is a reliable method for pre-operative diagnosis. Imaging like CT scan and MRI help to evaluate the primary lesion as well as distant metastasis. The majority of these cases can be managed by simple mastectomy. Axillary lymph node metastasis is rare and dissection should be limited to patients with pathological...
09:11
The Application and Analytical Pathway of Dexmedetomidine in Ischemia/Reperfusion Injury: Ischemia/reperfusion cerebral injury can cause serious damage to nerve cells. The injured organelles are cleared by autophagy eventually, which is critical for cell survival. Dexmedetomidine is neuroprotective in various ischemia/reperfusion models. Mitochondrial calcium uniporter (MCU) is the most important channel of mitochondrial Ca2+ influx into mitochondria, where Ca2+ has a potential effect on mitochondrial...
09:11
The Effect of Compound Sophora on Fluorouracil and Oxaliplatin Resistance in Colorectal Cancer Cells
The Effect of Compound Sophora on Fluorouracil and Oxaliplatin Resistance in Colorectal Cancer Cells: Fluorouracil (5-FU) and oxaliplatin (L-OHP) are the most commonly used chemotherapy drugs for colorectal cancer, though resistance is common. Compound Sophora injection is a traditional Chinese medicine that can protect the liver against oxidation, improve immunity, and enhance sensitivity to chemotherapy; it may have an effect of reversing resistance in 5-FU- and L-OHP-resistant gastric cancer cells...
09:11
IJERPH, Vol. 17, Pages 190: Antimicrobial Air Filters Using Natural Sea Salt Particles for Deactivating Airborne Bacterial Particles: IJERPH, Vol. 17, Pages 190: Antimicrobial Air Filters Using Natural Sea Salt Particles for Deactivating Airborne Bacterial ParticlesInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17010190Authors: Sang Bin Jeong Ki Joon Heo Byung Uk Lee We developed an antimicrobial air filter using natural sea salt (NSS) particles. Airborne...
09:10
GSE142619 Bone marrow-derived non-transformed murine macrophages with an unlimited self-renewing ability: Contributors : Hesham Nasser ; Partho Adhikary ; Amira Abdel-Daim ; Osamu Noyori ; Ryusho Kariya ; Seiji Okada ; Wenjuan Ma ; Masaya Baba ; Hitoshi Takizawa ; Mariko Yamane ; Hitoshi Niwa ; Shinya SuzuSeries Type : Expression profiling by arrayOrganism : Tissue macrophages derive from bone marrow monocytes, and recent studies using mice have revealed that they also derive from yolk...
09:10
GSE142627 Methylation Profiling of Medulloblastoma in a Clinical Setting Permits Sub-Classification and Reveals New Outcome Predictions: Contributors : Abedalthagafi Malak ; Snuderl MatijaSeries Type : Methylation profiling by arrayOrganism : In this study, we report the first examination of Medulloblastoma (MB) methylation patterns in Arab world, using an extensive primary tumor cohort in tertiray care center. We assessed DNA methylation patterns to sub-classify clinical MB cases and their amenability...
09:09
GSE142633 Next-generation sequencing of wild type and 5XFAD transcriptomes for Alzheimer's disease study: Contributors : Han S Koh ; Jin H Ryu ; Hyun J Cho ; Jae W MinSeries Type : Expression profiling by high throughput sequencingOrganism : We found some novel miRNA that targets SIRT1 may contribute to the pathogenesis in AD mouse model. We first identified that SIRT1 is significantly reduced in Alzheimer patient`s precentral gyrus and 5XFAD mice. To determine whether the strategy of inhibiting...
09:00
Changes in the morphology of the triangular fibrocartilage complex (TFCC) on magnetic resonance arthrography related to disruption of ulnar foveal attachment: AbstractObjectiveTo assess whether a proximal ligamentous component (PLC) of the triangular fibrocartilage complex (TFCC) with a distally prolapsing morphology is associated with the presence of a TFCC foveal tear on arthroscopy.MethodsOne-hundred thirty-two patients (134 wrists) who underwent MR arthrography and subsequent wrist arthroscopy...
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Opioid Use After Hospital Care due to Hip Fracture Among Community-Dwelling Persons With and Without Alzheimer's Disease: AbstractBackgroundHip fractures are common among persons with Alzheimer's disease (AD), but problems in pain assessment may lead to insufficient analgesia after hospitalization.ObjectiveWe investigated the prevalence of opioid use in the 6 months after discharge from hospital care due to hip fracture among community-dwellers with and without AD.Setting and methodThe Medication...
08:59
The influence of knee bolster on lumbar spinal stenosis parameters on MR images: AbstractObjectiveTo estimate the effect of the knee bolster use during an MRI on lumbar spinal stenosis parameters and low back pain-related disability.MethodsA repeated-measurement study of 27 males and 19 females with mean age 55.78 ± 14.36, referred for an MRI of the lumbar spine due to low back pain, performed with and without standard knee bolster. A radiologist evaluated the lumbar lordosis Cobb's angle, the cross-sectional...
08:59
The ring-shaped meniscus: a case series demonstrating the variation of imaging appearances on MRI: AbstractThe ring-shaped meniscus (RSM) is a rare meniscal variant in which there is an intermeniscal bridge between the anterior and posterior horns of the meniscus, thus forming a complete ring. The lateral meniscus is more commonly involved than the medial meniscus. Distinguishing an RSM from a bucket handle tear (BHT) with a displaced fragment in the intercondylar notch is challenging and there are...
08:58
Nodal metastases of soft tissue sarcomas: risk factors, imaging findings, and implications: AbstractSoft tissue sarcomas (STS) are malignancies derived from connective tissue, and regional lymph node metastasis (RLNM), while not common, is an important aspect of prognosis and treatment. Various risk factors, in particular the histological subtype, affect the likelihood of nodal involvement, which can be characterized by imaging features such as nodal dimension and morphology. Currently, surveillance...
08:58
A novel technique for retrieval of a broken biopsy needle: AbstractA broken needle is a rare complication of bone biopsy. We describe an easily applied technique of retrieval of a retained biopsy needle fragment using a cannulated drill typically used for internal fixation of femoral neck fractures. This approach allows for removal under moderate conscious sedation and can be performed by a radiologist using fluoroscopic or CT-fluoroscopic guidance in the radiology suite.
08:57
Cartilage degeneration post-meniscectomy performed for degenerative disease versus trauma: data from the Osteoarthritis Initiative: AbstractObjectiveTo compare the extent of cartilage deterioration in knees with prior meniscal resection related to trauma versus knees with resection related to degenerative disease, and to compare cartilage deterioration in knees with meniscal surgery to knees without meniscal surgery, controlling for prior knee trauma.Materials and methodsIn this cross-sectional study,...
08:57
Lumbosacral plexiform neurofibroma: a rare case in an adult without neurofibromatosis type I: AbstractPlexiform neurofibromas are an uncommon variant of neurofibromas that are described as being essentially pathognomonic of neurofibromatosis type 1 (NF1). Plexiform neurofibromas in the absence of NF1 are extremely rare. We present the case of a 38-year-old woman with a large multilobulated lumbosacral mass extending into the pelvis and proximal thigh. Histopathology of a CT-guided biopsy of the mass...
08:57
Subsynovial epidermal inclusion cyst of the knee: AbstractWe report a case of a subsynovial epidermal inclusion cyst in a 47-year-old woman with a painful spontaneous swelling of the right knee and a 2-year history of puncture and arthroscopy. Epidermal inclusion cysts are one of the most common benign subcutaneous tumours. Very rarely, they are located in an articulation and can cause an inflammatory reaction when rupture occurs. Simple surgical excision is the preferred therapy. The main goal of...
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The added value of SPECT-CT in the detection of heterotopic ossification on bone scintigraphy: AbstractPurposeHeterotopic ossification (HO) is the abnormal osteogenesis in non-skeletal tissue. It can be difficult to detect, as it can mimic other conditions clinically and on imaging studies. The purpose of this study was to find the added value of SPECT-CT in accurate detection of HO.Materials and methodsA total of 1780 reports on the PACS system of patients underwent bone scintigraphy at the Department...
08:56
Current status and recommendations for imaging in neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis: AbstractNeurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis (SWN) are three clinically distinct tumor predisposition syndromes with a shared tendency to develop peripheral and central nervous system neoplasms. Disease expression and complications of NF1, NF2, and SWN are highly variable, necessitating a multidisciplinary approach to care in order...
08:56
Current applications and future directions of deep learning in musculoskeletal radiology: AbstractDeep learning with convolutional neural networks (CNN) is a rapidly advancing subset of artificial intelligence that is ideally suited to solving image-based problems. There are an increasing number of musculoskeletal applications of deep learning, which can be conceptually divided into the categories of lesion detection, classification, segmentation, and non-interpretive tasks. Numerous examples of...
08:56
Bone mineral density measurement combined with vertebral fracture assessment increases diagnosis of osteoporosis in postmenopausal women: AbstractObjectiveOsteoporosis is diagnosed based on the results of BMD assessment and/or fragility fractures. Vertebral fracture is the most common fragility fracture. Many vertebral fractures are asymptomatic and are not clinically recognized. Early detection of vertebral fracture may increase diagnosis of osteoporosis. In this study, we performed BMD measurement...
08:54
Clinical utility of a postprocedural CT scan in CT-guided musculoskeletal biopsies: AbstractObjectiveThe purpose of this study is first to determine the clinical utility of the postprocedure scan in detecting postinterventional complications after CT-guided musculoskeletal biopsies, and second to evaluate the contribution to the radiation dose of the postprocedural CT scan.Materials and methodsRetrospective analysis of 500 consecutive CT-guided musculoskeletal biopsies over an 18-month period from...
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GSE142619 Bone marrow-derived non-transformed murine macrophages with an unlimited self-renewing ability: Contributors : Hesham Nasser ; Partho Adhikary ; Amira Abdel-Daim ; Osamu Noyori ; Ryusho Kariya ; Seiji Okada ; Wenjuan Ma ; Masaya Baba ; Hitoshi Takizawa ; Mariko Yamane ; Hitoshi Niwa ; Shinya SuzuSeries Type : Expression profiling by arrayOrganism : Mus musculusTissue macrophages derive from bone marrow monocytes, and recent studies using mice have revealed that they also derive...
08:54
GSE142620 Chronic inflammation induces epithelial-to-mesenchymal transition memory in non-small cell lung cancer: Contributors : Rui Li ; Stephanie L Ong ; Linh M Tran ; Zhe Jing ; Zhi L Huang ; Bin Liu ; Gina Lee ; Ramin Salehi-Rad ; Kostyantyn Krysan ; Paul C Pagano ; Manash K Paul ; Shili Xu ; Harvey R Herschman ; Steven M DubinettSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChronic inflammation facilitates tumor development. However, the underlying...
08:53
GSE142599 A Zebrafish JAK1-A634D Gain-of-Function Model Provides New Insights into the Pathogenesis of Familial Hypereosinophilia: Contributors : Anna Cordeiro-Santanach ; Sergey V Prykhozhij ; Adam P Deveau ; Gabriel Wajnberg ; Nicolas Crapoulet ; Stuart E Turvey ; Jason N BermanSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioJAK1 plays an important role during zebrafish development as hematopoietic regulator with a specific impact in the myeloid lineage,...
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GSE142633 Next-generation sequencing of wild type and 5XFAD transcriptomes for Alzheimer's disease study: Contributors : Han S Koh ; Jin H Ryu ; Hyun J Cho ; Jae W MinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe found some novel miRNA that targets SIRT1 may contribute to the pathogenesis in AD mouse model. We first identified that SIRT1 is significantly reduced in Alzheimer patient`s precentral gyrus and 5XFAD mice. To determine whether the strategy of...
08:53
GSE142625 SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth: Contributors : Chunwan Lu ; John D Klement ; Dafeng Yang ; Thomas Albers ; Iryna O Lebedyeva ; Jennifer L Waller ; Kebin LiuSeries Type : Expression profiling by arrayOrganism : Homo sapiens ; Mus musculusTranscriptional profiling of histone methyltransferase SUV39H1-selective small molecule inhibitor F5446-induced genes in human colon carcinoma cells. Tumor cells were treated with F5446 for 48h...
08:52
GSE139827 Single cell RNA sequencing for mouse femoral artery: Contributors : Bin Zhou ; Dong Gao ; Juan Tang ; Fei LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRapid regeneration of smooth muscle after vascular injury is essential for maintaining proper artery function. The current view holds that pre-existing smooth muscle proliferate and expand in responding to vascular injury, contributing to virtually all new smooth muscle cells. Whether resident...
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Multi-templates surface molecularly imprinted polymer for rapid separation and analysis of quinolones in water: AbstractRapid separation and analysis of trace quinolones (fleroxacin (FLRX), enoxacin (EN), norfloxacin (NOR), ciprofloxacin (CIP), enrofloxacin (ENRO), and lomefloxacin hydrochloride (LOME)) in real water samples were achieved by using a multi-templates molecularly imprinted polymer (MIP) based solid phase extraction (SPE) coupled with dispersive liquid-liquid microextraction (DLLME)...
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IJERPH, Vol. 17, Pages 191: Adolescents' Views on Seeking Help for Emotional and Behavioral Problems: A Focus Group Study: IJERPH, Vol. 17, Pages 191: Adolescents' Views on Seeking Help for Emotional and Behavioral Problems: A Focus Group StudyInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17010191Authors: Suzanne J. van den Toren Amy van Grieken Marjolein Lugtenberg Mirte Boelens Hein Raat This study aimed to get insight into adolescents' views on...
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Evaluation of Retinal Nerve Fiber Layer Thickness, Electroretinogram and Visual Evoked Potential in Patients with Alzheimer's Disease: Objective. To study the retinal nerve fibre layer (RNFL) thickness and visual electrophysiology testing in patients with Alzheimer's disease (AD). Methods. A cross-sectional, hospital-based study: 25 AD subjects and 25 controls were recruited. Candidates who fulfil the criteria with normal ocular examinations were made to proceed with scanning laser polarimetry, pattern...
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Wooden Penetrating Pelvic Trauma Passing the Foramen Ischiadicum: We describe the case of a 45-year-old woman who suffered an impalement injury of the pelvis with penetration of the sciatic foramen by a wooden foreign body. Following a single operation, the injury healed without complications or infection. We have taken this as an opportunity to describe the case and our standard procedure in more detail.1. IntroductionBefore we started writing this report, we chose the terms "penetrating pelvic...
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You're Being Watched Right Now | NYT Opinion: submitted by /u/mind_bomber [link] [comments]
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Granule of BU-XIN RUAN-MAI Attenuates the Patients' Angina Pectoris of Coronary Heart Disease via Regulating miR-542-3p/GABARAP Signaling: Objective. Coronary heart disease (CHD) has been regarded as a serious and common disease in the modern society. This study aims to investigate the effect of Granule of BU-XIN RUAN-MAI (BXRM) on angina pectoris of coronary heart disease and to explore the molecular mechanisms underlying Granule of BU-XIN RUAN-MAI-mediated protective activity against this disease....
08:47
The Effect of Compound Sophora on Fluorouracil and Oxaliplatin Resistance in Colorectal Cancer Cells
The Effect of Compound Sophora on Fluorouracil and Oxaliplatin Resistance in Colorectal Cancer Cells: Fluorouracil (5-FU) and oxaliplatin (L-OHP) are the most commonly used chemotherapy drugs for colorectal cancer, though resistance is common. Compound Sophora injection is a traditional Chinese medicine that can protect the liver against oxidation, improve immunity, and enhance sensitivity to chemotherapy; it may have an effect of reversing resistance in 5-FU- and L-OHP-resistant gastric cancer cells...
08:46
Quality of life is maintained with ixazomib maintenance in post‐transplant newly diagnosed multiple myeloma: the TOURMALINE‐MM3 trial: AbstractObjectivesHealth‐related quality of life (HRQoL) is particularly important during maintenance therapy (MT) in newly diagnosed multiple myeloma post‐transplant, when disease symptoms are limited.MethodsWe assessed HRQoL in patients randomised to 26 cycles of MT (ixazomib vs. placebo) in TOURMALINE‐MM3 (NCT02181413).ResultsCharacteristics at study entry were...
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Functional Brain Plasticity Associated with ACL Injury: A Scoping Review of Current Evidence: Anterior cruciate ligament (ACL) injury is a common problem with consequences ranging from chronic joint instability to early development of osteoarthritis. Recent studies suggest that changes in brain activity (i.e., functional neuroplasticity) may be related to ACL injury. The purpose of this article is to summarize the available evidence of functional brain plasticity after an ACL injury. A scoping review...
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GSE134604 Super-enhancer-associated oncogenes as novel therapeutic targets in osteosarcoma (ChIP-seq): Contributors : Jiajun Zhang ; Weihai Liu ; Changye Zou ; Zhiqiang Zhao ; Yuanying Lai ; Zhi Shi ; Xianbiao Xie ; Gang Huang ; Yongqian Wang ; Xuelin Zhang ; Zeipei Fan ; Qiao Su ; Junqiang Yin ; Jingnan ShenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensDespite the development of diagnostic and advanced treatment strategies, the...
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Viruses, Vol. 12, Pages 30: Influenza D Virus: Serological Evidence in the Italian Population from 2005 to 2017: Viruses, Vol. 12, Pages 30: Influenza D Virus: Serological Evidence in the Italian Population from 2005 to 2017Viruses doi: 10.3390/v12010030Authors: Claudia M. Trombetta Serena Marchi Ilaria Manini Otfried Kistner Feng Li Pietro Piu Alessandro Manenti Fabrizio Biuso Chithra Sreenivasan Julian Druce Emanuele Montomoli Influenza D virus is a novel influenza virus,...
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Chimeric antigen receptor -T cell therapy: Applications and challenges in treatment of allergy and asthma: Publication date: March 2020Source: Biomedicine & Pharmacotherapy, Volume 123Author(s): Abdolreza Esmaeilzadeh, Safa Tahmasebi, Seyyed Shamsadin AthariAbstractDespite the current advancements, cancer treatment approaches have limitations restricting their cure rate. Immunotherapy techniques are among novel and promising cancer therapeutic approaches. Therapeutic antibodies and adoptive cell...
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Cyclooxygenase activity in bradykinin-induced dermal extravasation. A study in mice and humans: ConclusionThese data suggest that COX activity contributes to bradykinin-induced dermal extravasation in mice and humans. In addition, our findings may open new treatment options and point to a potential activity of drugs interfering with the release of the COX substrate arachidonic acid, e.g. glucocorticoids.Graphical abstractGraphical illustration of the potential role of prostaglandin formation for...
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Lorlatinib in anaplastic lymphoma kinase-positive non-small cell lung cancer: Indian experience: Vikas T Talreja, Vanita Noronha, Vijay M Patil, Amit Joshi, Kumar PrabhashSouth Asian Journal of Cancer 2020 9(1):67-68Dear Editor,Lung cancer treatment is rapidly evolving and an excellent example of precision medicine. Outcome of anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) has improved significantly with recent report showing survival of 56% at 4 years.[1] This has been...
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Adequacy of surgical margins in oral cancer patients with respect to various types of reconstruction
Adequacy of surgical margins in oral cancer patients with respect to various types of reconstruction: Apurva Garg, Manish Mair, Hitesh Singhavi, Muddasir Bhati, Akshat Malik, Aseem Mishra, Deepa Nair, Sudhir Nair, Pankaj ChaturvediSouth Asian Journal of Cancer 2020 9(1):34-37Background: Surgical margin is an important prognostic factor for oral cancers (oral squamous cell carcinoma [OSCC]). The correlation of margin with the type of reconstruction has never been studied. Aim: This study aimed to...
08:41
Role of Cresp® in the management of chemotherapy-induced anemia in cancer patients: A real-world clinical practice audit: Ghanshyam Biswas, Avinash Pandey, Nikhil Ghadyalpatil, Nilesh Lokeshwar, Boben Thomas, Anita Ramesh, Yogesh Arora, Chandragouda Dodagoudar, Vibha Naik, Ashish Joshi, Indranil Ghosh, Rakesh Roy, Medhi Kunjahari, Tejinder Singh, Palanki Dattatreya Satya, Sachin Hingmire, Purvish M ParikhSouth Asian Journal of Cancer 2020 9(1):59-61Introduction: Anemia is a common, underestimated...
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Does preoperative CA-125 cutoff value and percent reduction in CA-125 levels correlate with surgical and survival outcome after neoadjuvant chemotherapy in patients with advanced-stage ovarian cancer? – Our experience from a tertiary cancer institute: Monisha Gupta, Shilpa Mukesh Patel, Ruchi Arora, Rajneesh Tiwari, Pariseema Dave, Ava Desai, Meeta MankadSouth Asian Journal of Cancer 2020 9(1):30-33Aim: The aim of the study is to evaluate percent fall in CA-125 levels after neoadjuvant chemotherapy...
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Epidemiology and clinical features of retinoblastoma: A tertiary care center's experience in India: Maneya Padma, Nuthan Kumar, Prerana S Nesargi, BS Aruna Kumari, L Appaji, Aarthi ViswanathanSouth Asian Journal of Cancer 2020 9(1):56-58Introduction: Retinoblastoma (RB) is a prototype of heritable cancers. It is more common in the lower socioeconomic strata. Delayed presentation significantly reduces the overall outcome. We have analyzed the epidemiological and clinical data of children who were...
08:40
Primary malignant mediastinal germ cell tumors: A single institutional experience: Subhasis Mishra, Saroj Kumar Das Majumdar, Mukund Sable, Dillip Kumar ParidaSouth Asian Journal of Cancer 2020 9(1):27-29Background: Primary mediastinal malignant germ cell tumour (PMMGCT) is rare with unsatisfactory prognosis and pose difficulty in management due to lack of guidelines. Methods: All cases of PMMGCT diagnosed and treated between years 2014 to 2018 were retrospectively evaluated for clinico-pathological...
08:40
The real-world experience with nivolumab in previously treated patients with advanced non-small cell lung cancer from a cancer center in India: Waseem Abbas, Rudra Prasad Acharya, Archit Pandit, Saurabh Gupta, Ranga Raju RaoSouth Asian Journal of Cancer 2020 9(1):50-52Background: PDL-1 inhibitors have emerged as the new standard of care for second line treatment of NSCLC. Methods: Eligible patients included, histologically proven NSCLC, ECOG (Eastern Cooperative Oncology Group) performance status...
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A tertiary care audit of using abiraterone acetate in patients of metastatic castrate-resistant prostate cancer: Amit Joshi, Sameer Shrirangwar, Vanita Noronha, Nilesh Sable, Archi Agarwal, Palak Popat, Atanu Bhattacharjee, Kumar PrabhashSouth Asian Journal of Cancer 2020 9(1):23-26Introduction: This is a retrospective analysis to assess the safety and efficacy of abiraterone acetate (AA) in metastatic castrate-resistant prostate cancer (mCRPC) patients treated at tertiary care institute. Materials...
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Nimotuzumab with intensity-modulated radiation therapy in unresectable and platinum-ineligible locally advanced head-and-neck cancer: K Satish Srinivas, Raja Sundaram, CV Divyambika, Sameer ChaudhariSouth Asian Journal of Cancer 2020 9(1):43-46Background: Outcomes with conventional treatment are poor in patients with squamous cell carcinoma of head and neck (SCCHN). Treatment options are further limited for patients ineligible to receive platinum-based chemotherapy due to various factors such as...
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A rare case of hyperprogression of nonsmall cell lung cancer in a patient on atezolizumab therapy: Sudarsan Vishnu Kollimuttathuillam, Supreet Kaur, Hamid Shaaban, Gunwant GuronSouth Asian Journal of Cancer 2020 9(1):22-29A 55-year-old Hispanic male with a history of hypertension presented with a 4-month history of dry cough along with mild chest pain in 2017 July when computed tomographic (CT) scan revealed right upper lobe (UL) mass with mediastinal adenopathy and innumerable pulmonary nodules....
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Occupational Injury and Its Correlated Factors among Small-Scale Industry Workers in Towns of Bale Zone, Southeast Ethiopia: Introduction. In developing countries, the laborer forces have managed many of the industrial works. As a result, the process of the work has put the health and lives of workers at risk. Thus, this study was designed to assess occupational injury and its correlated factors among small-scale industry workers in the towns of Bale Zone, Southeast Ethiopia. Methods. An institution-based...
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A prospective comparative study between concurrent chemoradiation with brachytherapy boost with concurrent chemoradiation alone in locally advanced cancer esophagus: Rajanigandha TuduSouth Asian Journal of Cancer 2020 9(1):20-22Context: Carcinoma esophagus is a highly malignant disease with very low cure rate. Concurrent chemoradiation is the standard of care in patients deemed unfit for surgery. Intraluminal brachytherapy (ILRT) is effective for palliation of dysphagia and is also used as a boost...
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How cancer of oral cavity affects the family caregivers? – A cross-sectional study in Wardha, India, using the Caregiver Quality of Life Index – Cancer questionnaire: Sourav Goswami, Subodh Saran GuptaSouth Asian Journal of Cancer 2020 9(1):62-65Introduction: Oral cancer is now a major public health problem in India. It does not only affect the patient, but also has a deep psychosocial impact on the family caregivers who are deeply involved with the cancer patient for nursing, timely medication,...
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Pediatric cancers in Bihar: A retrospective tertiary cancer center study: Avinash Pandey, Anjana Singh, Vijendra Kumar, Jayant Prakash, Ritesh Runu, Vinit Thakur, Anand Kumar Gupta, Shivkant SinghSouth Asian Journal of Cancer 2020 9(1):53-55Background: There is lack of information regarding pattern of distribution of pediatric cancers in Bihar. Aim: The aim of this study is to identify the pattern of distribution of pediatric cancers. Objectives: To analyze demographic data, type, and pattern of...
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Reliability of conventional Papanicolaou smear in diagnosing bacterial vaginosis among women with clinical genital infection: Kavita Vivek Anand, Sharmila Anil Pimple, Gauravi A Mishra, Rupali V Sahare, Saleem Pathuthara, Kedar K Deodhar, Surendra S ShastriSouth Asian Journal of Cancer 2020 9(1):13-16Objective: Bacterial vaginosis (BV) is a common reproductive tract infection (RTI) reported among Indian women. BV can influence the persistence of high-risk oncogenic human papillomavirus, a causative...
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Demography and treatment pattern of patients with head and neck carcinoma presenting to a tertiary care center in India: Need for urgent decentralization of cancer care: Mihir N Chandarana, Prathamesh S PaiSouth Asian Journal of Cancer 2020 9(1):38-42Aims: This study aims to report on the demographic profile and treatment pattern of head and neck cancer patients and impact of an early treatment decision on treatment. This study also aims to suggest recommendations to improve treatment compliance....
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Isolated regional nodal metastasis in giant cell tumor of the bone: Case report and review of literature: Kanuj Malik, Anand Raja, Sundersingh ShirleySouth Asian Journal of Cancer 2020 9(1):58-67Dear Editor,Giant cell tumors (GCTs) of the bone are benign osteolytic tumor commonly occurring in the third to fourth decades with distal femur being the most common site.[1] They form 5% of the primary skeletal tumors.[2] Metastasis though uncommon is usually seen with recurrences. Curettage with intralesional...
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An exceptional response to olaparib in relapsed and refractory BRCA2 mutated non-small cell lung cancer in hereditary breast–ovarian cancer syndrome: Vikas T Talreja, Vanita Noronha, Amit Joshi, Vijay Patil, Kumar PrabhashSouth Asian Journal of Cancer 2020 9(1):6-12Dear Editor,Poly (ADP-ribose) polymerase inhibitors (PARPi) have demonstrated impressive efficacy in BRCA-mutated gynecological malignancies.[1],[2] Several lines of evidence now support that the DNA Damage repair (DDR)-deficient populations...
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Lymph node metastasis in extremity chondrosarcomas: A series of four cases: Vineet Kurisunkal, Ashish Gulia, Ajay Puri, Bharat RekhiSouth Asian Journal of Cancer 2020 9(1):1-3Background: Primary bone sarcomas mainly metastasize through haematogenous route and rarely through lymph nodes due to paucity of lymphatic channels in the bone (1). Nodal spread in chondrosarcoma is extremely rare and there are two reported cases in literature including one previously published by our institute (3, 5). Aims...
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Incidence of febrile neutropenia with commonly used chemotherapy regimen in localized breast cancer: Nageswara Reddy Palukuri, Rajani Priya Yedla, Stalin Chowdary Bala, Siva Prasad Kuruva, Rachana Chennamaneni, Meher Lakshmi Konatam, Sadashivudu GundetiSouth Asian Journal of Cancer 2020 9(1):4-6Introduction: Breast cancer is the most frequently diagnosed cancer among the women. Most commonly used chemotherapy regimen is Doxorubicin and Cyclophosphamide (AC) which carries significant risk of febrile...
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Third-line therapy in the epidermal growth factor receptor mutation-positive advanced nonsmall-cell lung cancer: Vanita Noronha, Nikhil Pande, Amit Joshi, Vijay Patil, Vaishakhi Trivedi, Anuradha Chougule, Amit Janu, Abhishek Mahajan, Vikas Talreja, Kumar PrabhashSouth Asian Journal of Cancer 2020 9(1):47-49Introduction: The treatment of lung cancer is not defined in the third-line setting and remains an unanswered question. Erlotinib is the only drug approved in the third-line setting. With the...
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Two duodenal gastrointestinal stroma tumors: Management by minimally invasive surgery and then by conservative surgery: AbstractWe report the case of a 48‐year‐old woman treated for a gastrointestinal stroma tumor of the duodenum after presenting with upper gastrointestinal bleeding. She was treated with a combination of a radiological and endoscopic approach and minimally invasive surgery. During follow‐up, the patient developed a second metachronous duodenal gastrointestinal stroma tumor, distinct...
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Global and mitosis‐specific interobserver variation in mitotic count scoring and implications for malignant melanoma staging: AbstractAimsStaging is the gold standard for predicting malignant melanoma outcome but changes in its criteria over time indicate ongoing evolution. One notable recent change from the 8th edition of the AJCC staging manual was removal of mitotic count. We explore the extent that this feature is limited by interobserver error in order to find ways to improve its fitness for...
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An Unusual Initial Presentation of Diffuse Large B-Cell Lymphoma as Recurrent Syncope: We describe a rare presentation of diffuse large B-cell Lymphoma (DLBCL) with recurrent episodes of syncope. During the workup for syncope, the patient was incidentally found to have an extensive mass in the left thorax, which was later diagnosed as stage 2 bulky disease DLBCL. This is the rare case of lymphoma presenting as recurrent syncope without cardiac involvement. The patient did not have any further episodes...
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JCM, Vol. 9, Pages 70: Craniofacial Asymmetry from One to Three Years of Age: A Prospective Cohort Study with 3D Imaging: JCM, Vol. 9, Pages 70: Craniofacial Asymmetry from One to Three Years of Age: A Prospective Cohort Study with 3D ImagingJournal of Clinical Medicine doi: 10.3390/jcm9010070Authors: Anniina M. Launonen Ville Vuollo Henri Aarnivala Tuomo Heikkinen Pertti Pirttiniemi A. Marita Valkama Virpi Harila Deformational plagiocephaly (DP) is considered a risk factor for facial...
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GSE142513 Effects of a gastrin receptor antagonist (NTZ, previously named YF) on the gastric corpus mucosa of HKATPase betasubunit knockout (KO) mice: Contributors : Reidar Fossmark ; Flatberg ArnarSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: the effects of a gastrin receptor antagonist has been studies in patients with gastrin neuroendocrine (NE) tumours due to hypergastrinemia. This mouse model of hypergastrinemia is a model for studying long...
Mon Dec 23, 2019 08:59
Familial Adenomatous Polyposis and Desmoid Tumor Treated with Multivisceral Transplantation and Kidney Autotransplantation: Case Report and Literature Review: Introduction. Desmoid tumours (DT) are commonly associated with Gardener's syndrome. Their surgical resection may be complicated by their close proximity to major vessels, multiple organ involvement, and frequent local recurrence. Multivisceral transplantation (MVTx) is an alternative treatment for patients with intestinal and liver failure....
Mon Dec 23, 2019 08:58
Composition Characterization of Fatty Acid Zinc Salts by Chromatographic and NMR Spectroscopic Analyses on Their Fatty Acid Methyl Esters: To implement EU REACH- (Registration, Evaluation, and Authorization of Chemicals-) like chemical legislations in various countries of which the purpose is human and environment safety, the first step is substance identification followed by the hazard and risk assessments. Although both structural and composition identifications are required, the latter can more...
Mon Dec 23, 2019 08:58
Bone status of young adults with periodic avoidance of dairy products since childhood: AbstractProper nutrition throughout childhood and adolescence is crucial for normal bone development. We investigated whether adherence to Christian Orthodox Church fasting is characterized by periodic avoidance of animal foods (including dairy products), since childhood affects stature or bone health in young adults. This cross-sectional study included 200 healthy men and women, aged 18–35, of whom 100 had been...
Mon Dec 23, 2019 08:57
Melatonin modulates airway smooth muscle cell phenotype by targeting the STAT3/Akt/GSK-3β pathway in experimental asthma: AbstractAmong the troika of clinicopathologic features of asthma, airway remodelling has gained sufficient attention for its contribution to progressive airway narrowing. Much effort has been directed at the management of airway smooth muscle cells (ASMCs), but few attempts have proven to prevent the progression of remodelling. Recently, accumulating data have shown the anti-inflammatory/anti-proliferative...
Mon Dec 23, 2019 08:57
Deep-learning-based Detection and Segmentation-assisted Management on Brain Metastases: AbstractBackgroundThree-dimensional T1-magnetization-prepared rapid gradient-echo (3D-T1-MPRAGE) is preferred in detecting brain metastases (BMs) among MRI. We developed an automatic deep-learning-based detection and segmentation method for BMs (named BMDS net) on 3D-T1-MPRAGE images and evaluated its performance.MethodsThe BMDS net is a cascaded 3D fully convolution network (FCN) to automatically detect and segment...
Mon Dec 23, 2019 08:57
Exposure to metal fumes and circulating miRNAs in Algerian welders: AbstractPurposeA cross-sectional study was conducted in a group of Algerian welders to study the relationship between the exposure to metal particles from welding fumes and the concentration of three circulating miRNAs, miR-21, miR-146a and miR-155, as markers of renal function injury.MethodsCharacteristics of the subjects and the curriculum laboris were determined by questionnaires. We measured the concentrations of metals in blood...
Mon Dec 23, 2019 08:57
Diagnostic accuracy of transthoracic echocardiography for pulmonary hypertension: a systematic review and meta-analysis: ObjectiveTo evaluate the diagnostic accuracy of transthoracic echocardiography (TTE) in patients with pulmonary hypertension (PH).DesignSystematic review and meta-analysis.Data sources and eligibility criteriaEmbase, Cochrane Library for clinical trials, PubMed and Web of Science were used to search studies from inception to 19 June, 2019. Studies using both TTE and right heart...
Mon Dec 23, 2019 08:55
Synthesis of qualitative research studies regarding the factors surrounding UK critical care trial infrastructure: Conducting clinical trials in critical care is integral to improving patient care. Unique practical and ethical considerations exist in this patient population that make patient recruitment challenging, including narrow recruitment timeframes and obtaining patient consent often in time-critical situations. Units currently vary significantly in their ability to recruit according to infrastructure...
Mon Dec 23, 2019 08:55
Injury from electric scooters in Copenhagen: a retrospective cohort study: ObjectiveTo analyse injuries related to manual and electric scooter use from January 2016 up to and including July 2019.SettingElectric scooter rental services were launched in Denmark in January 2019. The services were provided by private companies. Although rules for handling and riding scooters have been established, no reports either before or after introduction of electric scooters anticipated the full extent of use,...
Mon Dec 23, 2019 08:55
Effectiveness and acceptability of cognitive-behavioural therapy based interventions for maternal peripartum depression: a systematic review, meta-analysis and thematic synthesis protocol: IntroductionPeripartum depression is a common mental health difficulty associated with a range of negative impacts for the mother, infant and wider family. This review will examine the effectiveness of cognitive–behavioural therapy (CBT) based interventions for peripartum depression. Secondary aims are to explore...
Mon Dec 23, 2019 08:55
Dry cupping in the treatment of individuals with non-specific chronic low back pain: a protocol for a placebo-controlled, randomised, double-blind study: BackgroundLow back pain is a very prevalent condition in the population and cupping therapy has been presented as a frequently used non-pharmacological treatment in this population. However, there is a lack of well-designed studies that evaluate the effects of this technique. This protocol describes a placebo-controlled, randomised, double-blind...
Mon Dec 23, 2019 08:54
Real-time utilisation of administrative data in the ED to identify older patients at risk: development and validation of the Dynamic Silver Code: ObjectiveIdentification of older patients at risk, among those accessing the emergency department (ED), may support clinical decision-making. To this purpose, we developed and validated the Dynamic Silver Code (DSC), a score based on real-time linkage of administrative data.Design and settingThe 'Silver Code National Project (SCNP)', a non-concurrent cohort...
Mon Dec 23, 2019 08:54
Care and outcomes of Canadian children hospitalised with periorbital and orbital cellulitis: protocol for a multicentre, retrospective cohort study: IntroductionSkin and soft tissue infections of the eye can be classified based on anatomic location as either anterior to the orbital septum (ie, periorbital cellulitis) or posterior to the orbital septum (ie, orbital cellulitis). These two conditions are often considered together in hospitalised children as clinical differentiation is difficult, especially...
Mon Dec 23, 2019 08:53
Concordance of chronic conditions among the household members in Shanghai: a cross-sectional study: ObjectivesMembers living in the same household tend to share some similar behaviours and environment. We want to quantitatively assess the associations of chronic conditions to investigate the concordance of disease status among the household members.SettingShanghai, China.ParticipantsOur data were from the fifth Health Service Survey in Shanghai in 2013. 12 002 households with 31 531 residents were...
Mon Dec 23, 2019 08:53
Presidential Address: Emotion Dysregulation in Children and Adolescents: I am both excited and proud to become president of our Academy of Child and Adolescent Psychiatry for the next 2 years. In addition to working with an incredible organization, I have had the privilege and pleasure of serving and collaborating with our immediate past presidents including Drs. Drell, Joshi, Fritz, and Wagner. In thinking about how I wanted to focus my energy and some of AACAP's resources over the next couple of...
Mon Dec 23, 2019 08:52
"The Need to See and Respond": The Role of the Child and Adolescent Psychiatrist in School Threat Assessment: Child and adolescent psychiatrists are on the front lines of performing challenging school threat assessments. With respect to school climate, clinicians should be aware of the presence of zero tolerance policies and inappropriate profiling. Removing a student from school does not eliminate the risk to the school community. School shootings often present similarly horrific themes and failures...
Mon Dec 23, 2019 08:52
Use of Bilateral Nasolabial Flaps with Coronoidectomy as a Novel Approach to a Case of Oral Cancer with Severe Trismus: AbstractPatients with oral malignancy often have associated trismus. Trismus is a debilitating condition that needs to be treated adequately with the release of fibrosis and interposition of vascularized tissue to provide long-term improvement in the mouth opening. Treatment of oral cancer in patients with severe trismus becomes challenging because of difficult access and further...
Mon Dec 23, 2019 08:51
Distal Femoral Varus Osteotomy for the Valgus Knee after Distal Femoral Growth Plate Fractures in Children: A Case Report: An 18-year-old male suffered a valgus injury to the right knee due to a fall during a bigfoot race he took part in when he was 15 years old. He visited a different hospital at the age of 15. No obvious ligament injury or fracture was noted on MRI and physical examination. However, he gradually became aware of the valgus deformity of the right knee. Finally, he could not take...
Mon Dec 23, 2019 08:51
Identification of a truncated {beta}1-chimaerin variant that inactivates nuclear Rac1 [Signal Transduction]: β1-chimaerin belongs to the chimaerin family of GTPase-activating proteins (GAPs) and is encoded by the CHN2 gene that also encodes the β2- and β3-chimaerin isoforms. All chimaerin isoforms have a C1 domain that binds diacylglycerol (DAG), as well as the tumor-promoting phorbol esters, and a catalytic GAP domain that inactivates the small GTPase Rac. Nuclear Rac has emerged as a key regulator...
Mon Dec 23, 2019 08:50
A fluorescent nanosphere-based immunochromatography test strip for ultrasensitive and point-of-care detection of tetanus antibody in human serum: AbstractTetanus still possesses a high infection risk and leads a number of human deaths in poor nations. Point-of-care and ultrasensitive detection of tetanus antibody levels in serum is the key to decrease the risk of tetanus infection and improve the health of people. In this work, by using ultra bright fluorescent nanospheres (FNs) and portable lateral...
Mon Dec 23, 2019 08:50
Cancer Stem Cells Equipped with Powerful Hedgehog Signaling and Better Epigenetic Memory: Avenues to Look for Cancer Therapeutics: Complex nature of the tumor is depicted at the cellular landscape by showing heterogeneity in the presence of cancer cells, cancer-associated stromal cells, mesenchymal stem cells and cancer stem cells (CSCs). One of the plausible views in cancer formation is suggested as the theory of cancer CSCs that is known as a source of initiation of tumorigenesis. In essence, these...
Mon Dec 23, 2019 08:49
Advances in In-Silico based Predictive In-Vivo Profiling of Novel Potent β-Glucuronidase Inhibitors: Background: Intestinal β-glucuronidase enzyme has a significant importance in colorectal carcinogenesis. Specific inhibition of the enzyme helps prevent immune reactivation of the glucuronide- carcinogens, thus protecting the intestine from ROS (Reactive Oxidative Species) mediatedcarcinogenesis. Objectives: Advancement in In-silico based techniques has provided a broad range of studies to carry out...
Mon Dec 23, 2019 08:49
Mogroside V Inhibits Hyperglycemia-induced Lung Cancer Cells Metastasis through Reversing EMT and Damaging Cytoskeleton: Background: Diabetes Mellitus (DM) accelerates progress of lung cancer. Hyperglycemia, a critical feature of DM, promotes lung cancer metastasis. Mogroside V is a triterpenoid glycoside from Siraitia grosvenorii. Interestingly, mogroside V not only plays an anti-diabetic role, but also has anti-tumor effects. Objective: In this study, we investigated the metastatic efficiency of...
Mon Dec 23, 2019 08:49
The Role of Large Neutral Amino Acid Transporter (LAT1) in Cancer: Background: The solute carrier family 7 (SLC7) can be categorically divided into two subfamilies, the L-type amino acid transporters (LATs) including SLC7A5-13, and SLC7A15, and the cationic amino acid transporters (CATs) including SLC7A1-4 and SLC7A14. Members of the CAT family transport predominantly cationic amino acids by facilitating diffusion with intracellular substrates. LAT1 (also known as SLC7A5), is defined as a heteromeric...
Mon Dec 23, 2019 08:49
Study of Serum Soluble Programmed Death Ligand 1 as a Prognostic Factor in Hepatocellular Carcinoma in Egyptian Patients: Background: The expression of programmed cell death ligands on tumor cells has a role in the suppression of antitumor immunity, resulting in tumor immune evasion. Objective: In this study, we evaluated the prognostic value of the soluble form of programmed death-ligand1 (sPD-L1) in Egyptian hepatocellular carcinoma (HCC) patients. Methods: This prospective cohort study was performed...
Mon Dec 23, 2019 08:48
The Role of Shcbp1 in Signaling and Disease: Src homolog and collagen homolog (Shc) proteins have been identified as adapter proteins associated with cell surface receptors and have been shown to play important roles in signaling and disease. Shcbp1 acts as a Shc SH2-domain binding protein 1 and is involved in the regulation of signaling pathways, such as FGF, NF-κB, MAPK/ERK, PI3K/AKT, TGF-β1/Smad and β -catenin signaling. Shcbp1 participates in T cell development, the regulation of downstream signal...
Mon Dec 23, 2019 08:48
Differential Expression of TOM34, AL1A1, PADI2 and KLRBA in NNK Induced Lung Cancer in Wistar Rats and their Implications: Background: Lung cancer is the most common cancer with a high mortality rate. The diagnosis only at advanced stages and lack of effective treatment are the main factors responsible for high mortality. Tobacco smoke is the major responsible factor for inflammation and tumor development in lungs. Objective: The present study was carried out to identify differentially expressed...
Mon Dec 23, 2019 08:48
Long-Term, Real-World Safety and Efficacy of Teneligliptin: A Post-Marketing Surveillance of More Than 10,000 Patients with Type 2 Diabetes in Japan: AbstractIntroductionTeneligliptin is a dipeptidyl peptidase 4 inhibitor that was approved for the treatment of type 2 diabetes mellitus (T2DM) in Japan in 2012. We performed a long-term post-marketing surveillance (RUBY) to obtain real-world evidence regarding the safety and efficacy of teneligliptin in Japan.MethodsThis 3-year follow-up RUBY surveillance...
Mon Dec 23, 2019 08:47
IJERPH, Vol. 17, Pages 115: Employment Experiences among Young Malaysian Adults with Learning Disabilities: IJERPH, Vol. 17, Pages 115: Employment Experiences among Young Malaysian Adults with Learning DisabilitiesInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17010115Authors: Dzalani Harun Normah Che' Din Hanif Farhan Mohd Rasdi Khadijah Shamsuddin The aim of this study was to describe the employment experiences of persons with learning disabilities...
Mon Dec 23, 2019 08:47
Synthesis of mesoporous magnetic polypyrrole and its application in studies of removal of acidic, neutral, and basic pharmaceuticals from aqueous medium: AbstractAs an alternative to traditional adsorbents, mesoporous magnetic polypyrrole (MMPPy) was first used as an adsorbent for the removal of acid, neutral, and basic pharmaceutical compounds considered aqueous pollutants. Ibuprofen (IBU, acid), caffeine (CAF, neutral), and bupropion (BUP, basic) were chosen as adsorbates and applied in adsorption...
Mon Dec 23, 2019 08:46
Association of the primary tumor's SUVmax with survival after surgery for clinical stage IA esophageal cancer: a single-center retrospective study: AbstractBackgroundCompared to other esophageal cancers, clinical stage IA esophageal cancer generally has a good prognosis, although a subgroup of patients has a poor prognosis. Unfortunately, clinical diagnoses of invasion depth or lymph node metastasis are not always accurate, which make it difficult to identify patients with a high risk of postoperative...
Mon Dec 23, 2019 08:45
Hypertension in HIV-Infected Patients Receiving Antiretroviral Therapy in Northeast Ethiopia: Background. With prolonged survival and aging of persons with HIV on combination antiretroviral therapy (ART), hypertension has emerged as a significant cause of morbidity and mortality globally. However, little is known about the burden of this comorbid condition among adults living with HIV in sub-Saharan Africa. In this study, we aimed to determine the prevalence and factors associated with hypertension...
Mon Dec 23, 2019 08:45
Novel Urinary Biomarkers for Acute Kidney Injury and Prediction of Clinical Outcomes After Pediatric Cardiac Surgery: AbstractAcute kidney injury (AKI) is a serious complication of pediatric cardiac surgery, with high morbidity and mortality. We aimed to evaluate the perioperative risk factors for AKI, and the validity of novel diagnostic urinary biomarkers after pediatric cardiac surgery. We analyzed 103 consecutive pediatric patients (≤ 18 years old), who underwent cardiac surgery. AKI was defined...
Mon Dec 23, 2019 08:45
Antibiotics, Vol. 9, Pages 8: The Structure Features and Improving Effects of Polysaccharide from Astragalus membranaceus on Antibiotic-Associated Diarrhea: Antibiotics, Vol. 9, Pages 8: The Structure Features and Improving Effects of Polysaccharide from Astragalus membranaceus on Antibiotic-Associated DiarrheaAntibiotics doi: 10.3390/antibiotics9010008Authors: Shanshan Li Yuli Qi Duoduo Ren Di Qu Yinshi Sun Astragalus membranaceus (Astragalus) is often used as a medical and food resource...
Mon Dec 23, 2019 08:45
Risk factors associated with delayed methotrexate clearance and increased toxicity in pediatric patients with osteosarcomaby Elizabeth P. Young, W. Susan Cheng, Melanie B. Bernhardt, Lisa L. Wang, Nino Rainusso, Jennifer H. Foster via Pediatric Blood & CancerAbstractHigh‐dose methotrexate (HD‐MTX; 12 g/m2) is part of standard therapy for pediatric osteosarcoma (OS). Risk factors associated with MTX toxicity in children with OS are not well defined. We investigated the association between peak...
Mon Dec 23, 2019 08:44
