Σάββατο, 27 Οκτωβρίου 2018

Outcome in ulcerative colitis after switch from Adalimumab/Golimumab to infliximab: A multicenter retrospective study

anti-TNF therapies Infliximab (IFX), Adalimumab (ADA), and Golimumab (GOL) are approved for treating moderate to severe ulcerative colitis (UC). In UC, only the switch from IFX to ADA has been investigated, reaching no more than 10–43% remission rates at 12 months.

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Long-term treatment with linaclotide of intestinal pseudo-obstruction secondary to Ehlers-Danlos syndrome



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Computer-aided detection of fasciculations and other movements in muscle with ultrasound: development and clinical application

Muscle ultrasound imaging is an increasingly important addition to the diagnostic arsenal for diagnosing neuromuscular disease, providing an anatomical assessment of muscle structure to complement standard neurological examination and electrophysiologic function testing (Simon, 2015). In addition to its well-known advantages of being patient-friendly, non-invasive and a point of care imaging technique, the dynamic nature of ultrasound images as a result of the high temporal resolution enables visualization of spontaneous or voluntary muscle movements, including fasciculations.

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The Revised Cerebral Recovery Index Improves Predictions of Neurological Outcome after Cardiac Arrest

About half of all comatose patients after cardiac arrest (CA) never regain consciousness because of severe postanoxic encephalopathy (PAE) (Sivaraju et al., 2015). Early prognosis may guide treatment decisions. Monitoring of cerebral functioning in the first 24 hours after CA with electroencephalography (EEG) has been demonstrated to enable reliable prediction of either good or poor neurological outcome in about 50% of the patients (Hofmeijer et al., 2015, 2014; Maher et al., 2015; Oddo and Rossetti, 2011; Rossetti et al., 2012, 2010; Tjepkema-Cloostermans et al., 2015).

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Outcome in ulcerative colitis after switch from Adalimumab/Golimumab to infliximab: A multicenter retrospective study

anti-TNF therapies Infliximab (IFX), Adalimumab (ADA), and Golimumab (GOL) are approved for treating moderate to severe ulcerative colitis (UC). In UC, only the switch from IFX to ADA has been investigated, reaching no more than 10–43% remission rates at 12 months.

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Long-term treatment with linaclotide of intestinal pseudo-obstruction secondary to Ehlers-Danlos syndrome



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Genome-wide regulatory gene-derived SSRs reveal genetic differentiation and population structure in fiber flax genotypes

Abstract

We designed a set of 580 simple sequence repeat markers; 506 from transcription factor-coding genes, and 74 from long non-coding RNAs and designated them as regulatory gene-derived simple sequence repeat (ReG-SSR) markers. From this set, we could anchor 559 ReG-SSR markers on 15 flax chromosomes with an average marker distance of 0.56 Mb. Thirty-one polymorphic ReG-SSR primers, amplifying SSR loci length of at least 20 bp were chosen from 134 screened primers. This primer set was used to characterize a diversity panel of 93 flax accessions. The panel included 33 accessions from India, including released varieties, dual-purpose lines and landraces, and 60 fiber flax accessions from the global core collection. Thirty-one ReG-SSR markers generated 76 alleles, with an average of 2.5 alleles per primer and a mean allele frequency of 0.77. These markers recorded 0.32 average gene diversity, 0.26 polymorphism information content and 1.35% null alleles. All the 31 ReG-SSR loci were found selectively neutral and showed no evidence of population reduction. A model-based clustering analysis separated the flax accessions into two sub-populations—Indian and global, with some accessions showing admixtures. The distinct clustering pattern of the Indian accessions compared to the global accessions, conforms to the principal coordinate analysis, genetic dissimilarity-based unweighted neighbor-joining tree and analysis of molecular variance. Fourteen flax accessions with 99.3% allelic richness were found optimum to adopt in breeding programs. In summary, the genome-wide ReG-SSR markers will serve as a functional marker resource for genetic and phenotypic relationship studies, marker-assisted selections, and provide a basis for selection of accessions from the Indian and global gene pool in fiber flax breeding programs.



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Impairment in Cardiac Vagal Tone Associated With Reduced Cerebral Blood Flow in Athletes Following Concussion

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Benjamin Williams, Justin Frantz, Kathleen Bell, Madeline Wainman, Sushmita Purkayastha, Sydney Lyng, Tonia Sabo



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Index to Authors of 2018 4th Federal Interagency Conference on Traumatic Brain Injury Abstracts

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s):



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Sleep Apnea and BMI Trajectory: a VA TBI Model Systems Study

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Dan Schwartz, Kayla Larosa, Marc Silva, Marie Saylors Gowen, Mo Modarres, Racine Brown, Risa Nakase-Richardson, Xinyu Tang



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Validity of the CES-D for Depression Screening In Military Personnel With Mild Traumatic Brain Injury

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Douglas Cooper, Jan Kennedy, Lisa Lu, Matthew Reid



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VA SmartHome for Caregivers of Veterans with Disorders of Consciousness

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Kristina Martinez, Steven Scott



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Using the NEO to Assess and Describe Personality in Mild TBI: Results and Implications

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Kristen Wortman, Michael Drexler, Shannon Casey



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Unmet Service Needs Among Post-Deployment Soldiers With And Without Traumatic Brain Injury

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Anne Bunner, Jay Schulz-Heik, Karen Schwab



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Turning the Tide: Real-World Turns are More Sensitive to mTBI Deficits Than Daily Activity Measures.

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): James Chesnutt, Laurie King, Lucy Parrington, Peter Fino, Samuel Stuart



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Treatment Approaches for Acute Post-Traumatic Headaches in Children

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Lynn Babcock, Nanhua Zhang, Steven Chan, Yin Zhang



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Trajectory of Orientation and Cognition of Moderate and Severe TBI in Acute Rehabilitation

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Amber Fahey, Amy Knight, Matthew Thompson, Olivio Clay, Sylvie Mrug, Thomas Novack



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Time-Course of Behavioral Recovery in Persons with Traumatic and Non-traumatic Disorders of Consciousness

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Andrea Christoforou, Jamie Kaminski, Joseph Giacino, Joseph Ostrow, Yelena Bodien



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The Relationship Between Problem-Solving Styles and Difficulties in Emotion Regulation in Individuals With TBI

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Elsa Lee, Eric Watson, Lisa Spielman, Maria Kajankova, Megan Putnam, Theodore Tsauosides, Wayne Gordon



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The Development of the Portable Warrior Test of Tactical Agility (POWAR-TOTAL)

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Julianna Prim, Karen McCulloch, Olcay Kursun, Oleg Favorov



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The CREACTIVE European TBI Follow-up Study: Comparison of a Single Center's Results Versus the Database

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Ákos Csomós, Gábor Nardai, Guido Bertolini, Orsolya Fábián



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Support and Health Outcomes Among Caregivers of Service Members and Veterans Following Traumatic Brain Injury

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Angela Driscoll, Diana Nora, Gartner Rachel, Jamie Sullivan, Janelle Cheselka, Jayne Holzinger, Louis French, Megan Wright, Nakita Pigford, Nicole Varbedian, Paula Bellini, Rael Lange, Sara Lippa, Tracey Brickell



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Supervision Needs Following Veteran and Service Member TBI: A VA TBI Model Systems Study

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Christina Dillahunt-Aspillaga, Erin Bailey, Leah Drasher-Phillips, Lillian Stevens, Nitin Patel, Risa Nakase-Richardson, Susan Ropacki, Xinyu Tang



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Sports Participation in Children with Mild and Complicated Mild Traumatic Brain Injury

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Colby Hansen, Masaru Teramoto



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Social Relations and PTSD Symptoms Influence mTBI Symptom Reporting in a Military Sample

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Evelyn Sikora, Jan Kennedy, Lisa Lu, Matthew Reid



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Social Communication Difficulties in Children with TBI and the Relationship to Measures of Social Cognition.

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Alison Haight, Eva Carrier, Helen Genova, Jean Lengenfelder, John DeLuca



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Sleep Architecture is Disrupted in Acquired Brain Injury Rehabilitation Inpatients with and without Sleep Apnea

Publication date: November 2018

Source: Archives of Physical Medicine and Rehabilitation, Volume 99, Issue 11

Author(s): Dan Schwartz, Danielle O'Connor, Karel Calero, Marc Silva, Mo Modarres, Risa Nakase-Richardson, William McDowell Anderson



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A practical approach to limit the radiation dose from building materials applied in dwellings, in compliance with the Euratom Basic Safety Standards

Publication date: January 2019

Source: Journal of Environmental Radioactivity, Volume 196

Author(s): Ronald C.G.M. Smetsers, Jasper M. Tomas

Abstract

Individuals receive a significant part of their radiation exposure indoors. We anticipate that this exposure is likely to increase in the near future, due to a growing use in the building industry of recycled materials and materials previously regarded as waste. Such materials often contain elevated levels of natural radionuclides. Directive 2013/59/Euratom ('Basic Safety Standards', BSS) pays comprehensive attention to indoor exposure from natural radionuclides, but proper implementation of all corresponding BSS regulations is not straightforward, especially when regarding the regulation of building materials containing so-called Annex XIII materials. In this paper, we discuss the most relevant deficiencies in the BSS and present a practical approach to cope with these. Our most important observation is that adequate methods for assessing the annual dose due to gamma radiation from building materials are not provided by the BSS. This is in particular difficult because compliance of single building materials has to be tested, but the corresponding BSS reference level refers to gamma radiation emitted by all building materials present in a room. Based on a simple model of three layers of building materials, we present a set of operational conditions for building materials, either used for construction purposes ('bulk layers') or for the finishing of walls, floors and ceilings ('superficial layers'). Any customary combination of building materials meeting these conditions will stay below the BSS reference level for gamma radiation. This statement holds for the middle of a reference room, but is not always the case close to the walls, especially when low density materials with a relatively high content of natural radionuclides are present at the inner side of the room. This can be avoided by applying more strict conditions for those kind of materials than presented in this paper. We further focus on the indoor exposure to thoron progeny. Building materials that pass the test for gamma radiation can still be a significant source for indoor air concentrations of thoron progeny. When the average annual thoron inhalation dose were to be restricted to 1 mSv a−1 − a level comparable to the BSS reference level for gamma radiation − the activity concentration of Ra-224 in (especially porous) building materials used for wall finishing purposes should be limited to a value of typically 50 Bq kg−1. Even if our suggested approach of the BSS regulations is fully implemented, it still allows for a significant increase in the average radiation exposure in dwellings due to external radiation and thoron progeny. However, the situation will be worse if a less strict interpretation of the BSS regulations will be applied.



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Least-cost pathway models indicate northern human dispersal from Sunda to Sahul

Publication date: December 2018

Source: Journal of Human Evolution, Volume 125

Author(s): Shimona Kealy, Julien Louys, Sue O'Connor

Abstract

Archaeological records from Australia provide the earliest, indirect evidence for maritime crossings by early modern humans, as the islands to the north-west of the continent (Wallacea) have never been connected to the mainland. Suggested in 1977 by Joseph B. Birdsell, the two main routes from Sunda (mainland Southeast Asia) to Sahul (Australia-New Guinea), still in debate today, are a northern route through Sulawesi with a landing in New Guinea, or a southern route through Bali, Timor and thence landing in northern Australia. Here we construct least-cost pathway models of human dispersal from Sunda to Sahul at 65 ka and 70 ka by extending previous out-of-Africa least-cost models through the digitization of these routes. We recover overwhelming support for a northern route into Sahul, with a landing location on present-day Misool Island. Minimal support is also recovered for the southern route at 70 ka, with a possible crossing to Sahul from eastern Timor. Review of archaeological records on the Wallacean islands crossed by our northern route indicate a dearth of archaeological research in this region. Meanwhile, the comparatively better studied southern islands still lack any archaeological dates comparable to those known for initial occupation in Sunda and Sahul. Based on our model results we suggest Misool Island as the initial landing site for early modern humans on Sahul and recommend a future focus on archaeological fieldwork in the northern Wallacean islands.



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A new species of Simiolus from the middle Miocene of the Tugen Hills, Kenya

Publication date: December 2018

Source: Journal of Human Evolution, Volume 125

Author(s): James B. Rossie, Andrew Hill

Abstract

A new species of the "small-bodied ape" Simiolus is described here that extends the temporal range of the genus to the end of the Middle Miocene. As such, it is one of the few species of fossil primates known from East Africa during a time of significant change in which Old World monkeys and crown hominoids replaced the primitive ape-like primates that had dominated the early Miocene. The dynamics of this important event in our evolutionary history are obscured by the small number of fossil primates known from Africa between 14 and 6 million years ago, as well as persistent ambiguity regarding the phylogenetic status of the ape-like Miocene primates. The new species described here helps to fill this temporal gap, and our analysis of its phylogenetic position suggests that Simiolus and many other Miocene primates were not only ape-like, they were, indeed, stem hominoids. Judging from the available material, the new species may be the smallest known ape.



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FN400 and sustained negativity reveal a premise monotonicity effect during semantic category-based induction

Publication date: Available online 27 October 2018

Source: International Journal of Psychophysiology

Author(s): Ruifang Cui, Yang Liu, Changquan Long

Abstract

The premise monotonicity effect during category-based induction is a robust effect that occurs when generalization of a novel property shared by many cases is more likely than one shared by few cases. The timing of brain activity during this effect is unclear. Therefore, the event-related potentials (ERPs) underpinning this effect were measured by manipulating the premise sample size (single [S] vs. two [T]) in a semantic category-based induction task, with the conclusion categories either including the premise categories (congruent induction) or not (incongruent induction). The behavioral results replicated the premise monotonicity effect, and revealed that S arguments produced longer reaction times and more conservative response criteria than did T arguments. This suggests that the premise monotonicity effect was affected by both evidence accumulation speed and decision threshold. ERP results demonstrated that the premise monotonicity effect was reflected by two parameters during inductive decision: (1) S arguments elicited larger FN400 amplitudes than did T arguments under congruent induction, which was linked to reduced global similarity, decreased cognitive relevance, and attenuated conceptual fluency and (2) S arguments elicited larger sustained negativity (SN) in the 450–1050-ms time window than did T arguments, which is related to more inference-driven integration and interpretive processes. Our findings provide insight into the complex temporal course of the premise monotonicity effect during semantic category-based induction.



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Mixed Blessings from a Cambridge Union, Elizabeth N Anionwu



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Computer-aided detection of fasciculations and other movements in muscle with ultrasound: development and clinical application

Publication date: Available online 27 October 2018

Source: Clinical Neurophysiology

Author(s): Kaj Gijsbertse, Max Bakker, André Sprengers, Juerd Wijntjes, Saskia Lassche, Nico Verdonschot, Chris L. de Korte, Nens van Alfen

Abstract
Objective

To develop an automated algorithm for detecting fasciculations and other movements in muscle ultrasound videos. Fasciculation detection in muscle ultrasound is routinely performed online by observing the live videos. However, human observation limits the objective information gained. Automated detection of movement is expected to improved sensitivity and specificity and increase reliability.

Methods

We used 42 ultrasound videos from 11 neuromuscular patients for an iterative learning process between human observers and automated computer analysis, to identify muscle ultrasound movements. Two different datasets were selected from this, one to develop the algorithm and one to validate it. The outcome was compared to manual movement identification by clinicians. The algorithm also quantifies specific parameters of different movement types, to enable automated differentiation of events.

Results

The algorithm reliably detected fasciculations. With algorithm guidance, observers found more fasciculations compared to visual analysis alone, and prescreening the videos with the algorithm saved clinicians significant time compared to reviewing full video sequences. All videos also contained other movements, especially contraction pseudotremor, which confused human interpretation in some.

Conclusions

Automated movement detection is a feasible and attractive method to screen for fasciculations in muscle ultrasound videos.

Significance

Our findings affirm the potential clinical usefulness of automated movement analysis in muscle ultrasound.



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The Revised Cerebral Recovery Index Improves Predictions of Neurological Outcome after Cardiac Arrest

Publication date: Available online 27 October 2018

Source: Clinical Neurophysiology

Author(s): Sunil B Nagaraj, Marleen C. Tjepkema-Cloostermans, Barry J. Ruijter, Jeannette Hofmeijer, Michel J.A.M. van Putten

Abstract
Objective

Analysis of the electroencephalogram (EEG) background pattern helps predicting neurological outcome of comatose patients after cardiac arrest (CA). Visual analysis may not extract all discriminative information. We present predictive values of the revised Cerebral Recovery Index (rCRI), based on continuous extraction and combination of a large set of evolving quantitative EEG (qEEG) features and machine learning techniques.

Methods

We included 551 subsequent patients from a prospective cohort study on continuous EEG after CA in two hospitals. Outcome at six months was classified as good (Cerebral Performance Category (CPC) 1-2) or poor (CPC 3-5). Forty-four qEEG features (from time, frequency and entropy domain) were selected by the least absolute shrinkage and selection operator (LASSO) method and used in a Random Forests classification system. We trained and evaluated the system with 10-fold cross validation. For poor outcome prediction, the sensitivity at 100% specificity (Se100) and the area under the receiver operator curve (AUC) were used as performance of the prediction model. For good outcome, we used the sensitivity at 95% specificity (Se95).

Results

Two hundred fifty-six (47%) patients had a good outcome. The rCRI predicted poor outcome with AUC = 0.94 (95% CI: 0.83-0.91), Se100= 0.66 (0.65-0.78), and AUC = 0.88 (0.78-0.93), Se100= 0.60 (0.51-0.75) at 12 and 24 hours after CA, respectively. The rCRI predicted good outcome with Se95= 0.72 (0.61-0.85) and 0.40 (0.30-0.51) at 12 and 24 hours after CA, respectively.

Conclusions

Results obtained in this study suggest that with machine learning algorithms and large set of qEEG features, it is possible to efficiently monitor patient outcome after CA. We also demonstrate the importance of selection of optimal performance metric to train a classifier model for outcome prediction.

Significance

The rCRI is a sensitive, reliable predictor of neurological outcome of comatose patients after CA.



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Applications of neuromuscular ultrasound in amyotrophic lateral sclerosis

Publication date: Available online 26 October 2018

Source: Clinical Neurophysiology

Author(s): Tze Chao Wee, Neil G. Simon



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Concentric or Monopolar Electrode for Jitter Determination in Orbicularis Oculi

Publication date: Available online 26 October 2018

Source: Clinical Neurophysiology

Author(s): Miguel Oliveira Santos, Michael Swash, Mamede de Carvalho

Abstract
Objectives

To investigate if monopolar (MN) and concentric (CN) electrodes are equivalent for volitional contraction jitter estimation in orbicularis oculi (OO), and to study the effect of selecting a specific high-pass filter.

Methods

We studied neuromuscular jitter in OO on both sides in 100 consecutive patients with a clinical diagnosis of ocular myasthenia gravis (MG). We used either MN (50 patients) or CN (50 patients) electrodes in individual patients, according to a randomised protocol, with a 1kH high pass filter on one side and a 3kH filter on the other. Ten or more potential pairs were studied on each side.

Results

48 patients had a definite clinical diagnosis of ocular MG, and 52 of mimicking-disorders, who were analysed as controls. In controls, jitter (MCD) showed a normal distribution independent of the electrode type or filter settings. The mean jitter value and the number of abnormal pairs (>10%) was similar in MN and CN recordings, with both 1 kHz and 3 kHz filters. Sensitivity was 73% for mean jitter and 94% for number of abnormal pairs. Specificity was 100%.

Conclusions

The jitter in OO using MN or CN was similar in controls and the diagnostic sensitivity was similar using either electrode in patients with ocular MG. The use of high-pass filters of 1 or 3 kHz did not influence these results.

Significance

MN and CN are both suitable for determining volitional jitter in OO.



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LOXL3 novel mutation causing a rare form of autosomal recessive Stickler syndrome

Clinical Genetics, Volume 0, Issue ja, -Not available-.


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Neurologic challenges in 22q11.2 deletion syndrome

American Journal of Medical Genetics Part A, EarlyView.


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The effect of an immersive virtual reality tour of the operating theater on emergence delirium in children undergoing general anesthesia: A randomized controlled trial

Pediatric Anesthesia, Volume 0, Issue ja, -Not available-.


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Lowry-Wood syndrome: further evidence of association with RNU4ATAC , and correlation between genotype and phenotype

Abstract

Lowry-Wood syndrome (LWS) is a skeletal dysplasia characterized by multiple epiphyseal dysplasia associated with microcephaly, developmental delay and intellectual disability, and eye involvement. Pathogenic variants in RNU4ATAC, an RNA of the minor spliceosome important for the excision of U12-dependent introns, have been recently associated with LWS. This gene had previously also been associated with microcephalic osteodysplastic primordial dwarfism (MOPD) and Roifman syndrome (RS), two distinct conditions which share with LWS some skeletal and neurological anomalies. We performed exome sequencing in two individuals with Lowry-Wood syndrome. We report RNU4ATAC pathogenic variants in two further patients. Moreover, an analysis of all RNU4ATAC variants reported so far showed that FitCons scores for nucleotides mutated in the more severe MOPD are higher than RS or LWS and that they were more frequently located in the 5′ Stem–Loop of the RNA critical for the formation of the U4/U6.U5 tri-snRNP complex, whereas the variants are more dispersed in the other conditions. We are thus confirming that RNU4ATAC is the gene responsible for LWS and provide a genotype–phenotype correlation analysis.



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Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1–PPP1CB complexes

Abstract

RASopathies are a group of developmental disorders caused by mutations in genes that regulate the RAS/MAPK pathway and include Noonan syndrome (NS), Costello syndrome, cardiofaciocutaneous syndrome and other related disorders. Whole exome sequencing studies recently identified LZTR1, PPP1CB and MRAS as new causative genes in RASopathies. However, information on the phenotypes of LZTR1 mutation-positive patients and functional properties of the mutations are limited. To identify variants of LZTR1, PPP1CB, and MRAS, we performed a targeted next-generation sequencing and reexamined previously analyzed exome data in 166 patients with suspected RASopathies. We identified eight LZTR1 variants, including a de novo variant, in seven probands who were suspicious for NS and one known de novo PPP1CB variant in a patient with NS. One of the seven probands had two compound heterozygous LZTR1 variants, suggesting autosomal recessive inheritance. All probands with LZTR1 variants had cardiac defects, including hypertrophic cardiomyopathy and atrial septal defect. Five of the seven probands had short stature or intellectual disabilities. Immunoprecipitation of endogenous LZTR1 followed by western blotting showed that LZTR1 bound to the RAF1–PPP1CB complex. Cells transfected with a small interfering RNA against LZTR1 exhibited decreased levels of RAF1 phosphorylated at Ser259. These are the first results to demonstrate LZTR1 in association with the RAF1–PPP1CB complex as a component of the RAS/MAPK pathway.



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Genioglossus activation during maximal sniff manoeuvres: Is upper airway function relevant in the clinical assessment of inspiratory and expiratory muscle strength?

Experimental Physiology, Volume 0, Issue ja, -Not available-.


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Characterisation and regulation of wild type and mutant TASK‐1 two pore domain potassium channels indicated in pulmonary arterial hypertension

The Journal of Physiology, Volume 0, Issue ja, -Not available-.


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Neurons in the superior colliculus wake up to see things differently

The Journal of Physiology, Volume 0, Issue ja, -Not available-.


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Projections, where art thou: The state and future of the central amygdala

The Journal of Physiology, Volume 0, Issue ja, -Not available-.


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