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Sensory feedback is critical for grasping in able-bodied subjects. Consequently, closing the loop in upper-limb prosthetics by providing artificial sensory feedback to the amputee is expected to improve the pr...
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Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 574-578
DOI: 10.1055/a-0636-1776
Georg Thieme Verlag KG Stuttgart · New York
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Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 567-568
DOI: 10.1055/a-0668-3904
Georg Thieme Verlag KG Stuttgart · New York
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Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 618-630
DOI: 10.1055/s-0043-111004
Zentrale Aspekte der Anästhesieführung bei neurochirurgischen Operationen sind das Aufrechterhalten der zerebralen Homöostase sowie die Vermeidung sekundärer Hirnschäden. Die wichtigsten Variablen sind zerebraler Metabolismus, zerebraler Blutfluss, zerebraler Perfusionsdruck, zerebrales Blutvolumen und ihr Einfluss auf den intrakraniellen Druck. Die Ausgewogenheit dieser Faktoren ist Ziel bei jeder neurochirurgischen Operation oder Intervention.
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Georg Thieme Verlag KG Stuttgart · New York
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Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 568-569
DOI: 10.1055/a-0668-3886
Georg Thieme Verlag KG Stuttgart · New York
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Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 592-604
DOI: 10.1055/s-0043-121685
Die Patientenaufklärung ist „täglich Brot" des klinisch tätigen Anästhesisten und gleichzeitig ein zentrales Rechtfertigungselement medizinischer Behandlungsmaßnahmen. Durch Auslösen von Placebo- und Noceboeffekten kann sie den Behandlungserfolg aber auch selbst maßgeblich beeinflussen. Einem daraus drohenden Konflikt verschiedener medizinethischer Prinzipien kann mit entsprechenden praktischen Strategien wirksam begegnet werden.
[...]
Georg Thieme Verlag KG Stuttgart · New York
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Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 568-568
DOI: 10.1055/a-0668-3958
Georg Thieme Verlag KG Stuttgart · New York
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Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 635-638
DOI: 10.1055/a-0591-1169
Schlichtungsstellen für Arzthaftpflichtfragen bieten Patienten, Ärzten und Versicherern eine Möglichkeit, Arzthaftungsstreitigkeiten außergerichtlich zu klären. In der Rubrik „Fälle der Schlichtungsstelle" stellen wir abgeschlossene Fälle aus der Schlichtungsstelle für Arzthaftpflichtfragen der norddeutschen Ärztekammern vor.
[...]
Georg Thieme Verlag KG Stuttgart · New York
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Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 569-570
DOI: 10.1055/a-0668-3750
Georg Thieme Verlag KG Stuttgart · New York
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Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 579-590
DOI: 10.1055/s-0043-121684
Placebo- und Noceboeffekte stehen aktuell sehr im Fokus der klinischen und experimentellen Schmerzforschung. Neuro- sowie psychophysiologische Prozesse scheinen eine wichtige Rolle bei der Entstehung sowie Vermittlung zu spielen. So werden Placebo- und Noceboeffekte im Wesentlichen über das Netzwerk des opioidergen, absteigenden, schmerzmodulierenden Systems vermittelt. Für das Zustandekommen eines Placeboeffektes wiederum werden 3 psychologische Mechanismen verantwortlich gemacht: klassische Konditionierung, soziales Lernen sowie die Schmerzerwartung. Eine offene Analgetikagabe, eine ausführliche Aufklärung über Wirkung und Nebenwirkung (ohne diese zu sehr in den Fokus zu stellen) der im perioperativen Bereich eingesetzten Medikamente und Interventionen sowie eine Einbindung des Patienten in die Therapie (z. B. durch patientenkontrollierte Systeme) können zu einer additiven Verbesserung der Akutschmerztherapie (bis zu 30%) führen.
[...]
Georg Thieme Verlag KG Stuttgart · New York
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Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 572-572
DOI: 10.1055/a-0667-9094
Georg Thieme Verlag KG Stuttgart · New York
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Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 605-617
DOI: 10.1055/s-0043-121683
Spielte der Placeboeffekt ehemals vorwiegend eine (eher unliebsame) Rolle bei randomisierten kontrollierten Studien, so treten nun vermehrt die mit dem Placeboeffekt verbundenen Chancen in den Vordergrund. Dieser Beitrag bespricht bisherige Forschungserkenntnisse zum Placeboeffekt bei chronischen Schmerzen und zeigt, wie durch eine gezielte Beeinflussung des therapeutischen Kontexts die Wirksamkeit pharmakologisch aktiver Schmerzmedikamente gesteigert werden kann.
[...]
Georg Thieme Verlag KG Stuttgart · New York
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Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 572-573
DOI: 10.1055/a-0667-9117
Georg Thieme Verlag KG Stuttgart · New York
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Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 566-567
DOI: 10.1055/a-0668-3940
Georg Thieme Verlag KG Stuttgart · New York
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Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 631-634
DOI: 10.1055/a-0628-3122
Die „Rapid Sequence Induction and Intubation" (RSI oder RSII) ist bei Patienten mit erhaltener Kreislauffunktion die Standardmethode, um schnellstmöglich eine Atemwegssicherung im Rahmen einer Notfallsituation bzw. Narkose durchzuführen. Ziel einer RSI ist es, eine Aspiration durch die schnelle endotracheale Intubation und den Verzicht auf eine Zwischenbeatmung zu verhindern.Auch heute besitzen nur wenige europäische Länder eine explizite Handlungsempfehlung zur Durchführung einer RSI. In der täglichen klinischen Routine hat sich die Kopfhochlagerung etabliert, die gegenüber den anderen Lagerungsarten gewisse Vorteile bietet. Eine liegende Magensonde sollte i. d. R. während der RSI belassen werden und muss nicht zwingend in den Ösophagus zurückgezogen werden. Wenn keine Magensonde gelegt wurde bzw. bereits lag, ist die Einlage einer Magensonde nach Intubation sinnvoll. Vor der RSI sollte im Normalfall ein Opioid appliziert werden, da die Dosis kreislaufwirksamer Hypnotika und die hämodynamische Stimulation bei der Intubation reduziert werden können.
[...]
Georg Thieme Verlag KG Stuttgart · New York
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Advancements in surgical techniques and experience of donor–recipient pairing has led to a wider use of right split liver grafts in adults. An update meta-analysis was conducted to compare right split liver graft (RSLG) and whole liver transplantation (WLT) using traditional and cumulative approaches.
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The histologic discrepancies between preoperative endoscopic forceps biopsy (EFB) and endoscopic submucosal dissection (ESD) specimens sometimes confuse the endoscope operator. This study aimed to analyze the limitation of the biopsy-based diagnosis before ESD and to evaluate which factors affect the discordant pathologic results between EFB and ESD.
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Advancements in surgical techniques and experience of donor–recipient pairing has led to a wider use of right split liver grafts in adults. An update meta-analysis was conducted to compare right split liver graft (RSLG) and whole liver transplantation (WLT) using traditional and cumulative approaches.
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The histologic discrepancies between preoperative endoscopic forceps biopsy (EFB) and endoscopic submucosal dissection (ESD) specimens sometimes confuse the endoscope operator. This study aimed to analyze the limitation of the biopsy-based diagnosis before ESD and to evaluate which factors affect the discordant pathologic results between EFB and ESD.
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The American Academy of Pediatrics recommends that adolescents be screened for mental health concerns and receive anticipatory guidance on stress management strategies.
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Child maltreatment is a serious public health concern in the United States. Young infants and children younger than 3 years are at the highest risk of being abused and can experience both acute injuries and long-term developmental, behavioral, and mental health problems. Health care providers are mandated reporters of suspected abuse but may misdiagnose potentially abusive injuries because of lack of knowledge in recognizing maltreatment. Premobile infants rarely have bruising or intraoral injuries without a reported accident or underlying systemic disease and should raise concern for abuse.
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The Journal of Physiology, Volume 0, Issue ja, -Not available-.
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Adolescent cricket pace bowlers are prone to non-contact shoulder, low back and lower-limb injuries. Exercise-based injury prevention programmes (IPPs) are effective for reducing non-contact injuries in athletes; however, a specific programme for adolescent pace bowlers has not been published. This paper therefore seeks to provide a rationale for the development of an exercise-based IPP specific for adolescent pace bowlers. It also outlines design principles and provides an example exercise programme that can be implemented at the community level. In addition, the paper addresses other injury prevention techniques concerned with the prescription of appropriate bowling loads and the modification of poor bowling biomechanics. Performing an exercise-based IPP before cricket training could reduce injury rates in adolescent pace bowlers. Eccentric strengthening exercises can be employed to target injuries to the posterior shoulder muscles, hip adductors and hamstring muscles. The risk of low back, knee and ankle injury could also be reduced with the inclusion of dynamic neuromuscular control exercises and trunk extensor endurance exercises. Other prevention strategies that need to be considered include the modification of poor bowling biomechanics, such as shoulder counter-rotation and lateral trunk flexion. Coaches and players should also aim to quantify bowling load accurately and coaches should use this information to prescribe appropriate individualised bowling loads. Specifically, players would benefit from avoiding both long periods of low load and acute periods when load is excessively high. Future evidence is needed to determine the effectiveness of the example programme outlined in this paper. It would also be beneficial to investigate whether the modification of bowling biomechanics is achievable at the non-elite level and if bowling load can be accurately measured and manipulated within a community-level population.
The inflammatory bowel diseases (IBD) are particularly common among the Ashkenazi Jewish (AJ) population. Population-specific estimates of familial risk are important for counseling; however, relatively small cohorts of AJ IBD patients have been analyzed for familial risk to date. This study aimed to recruit a new cohort of AJ IBD patients, mainly from the UK, to determine the familial occurrence of disease.
A total of 864 AJ IBD patients were recruited through advertisements, hospital clinics, and primary care. Participants were interviewed about their Jewish ancestry, disease phenotype, age of diagnosis, and family history of disease. Case notes were reviewed.
The 864 probands comprised 506 sporadic and 358 familial cases, the latter with a total of 625 affected relatives. Of the UK cases, 40% had a positive family history with 25% having at least one affected first-degree relative. These percentages were lower among those recruited through hospital clinics and primary care (33% for all relatives and 22% among first-degree relatives). Examining all probands, the relative risk of IBD for offspring, siblings, and parents was 10.5, 7.4, and 4, respectively. Age of diagnosis was significantly lower in familial versus sporadic patients with Crohn's disease.
This study reports familial risk estimates for a significant proportion of the AJ IBD population in the UK. The high rate of a positive family history in this cohort may reflect the greater genetic burden for IBD among AJs. These data are of value in predicting the likelihood of future recurrence of IBD in AJ families.
Impaired physical capacity increases peri-liver transplant complications. Patient perceptions regarding exercise prior to transplantation are not known.
This study aimed to assess patient and caregiver activity levels, perceptions of willingness to exercise, and of provider advice.
Consecutive patients listed for liver transplant and caregivers presenting for routine outpatient visits were evaluated over a 3-month interval. Anonymous surveys adapted to patients and caregivers addressed the importance and safety of exercise, type and duration of exercise performed, barriers, willingness to wear a monitoring device, and perceived provider recommendations. Responses were logged on a Likert scale from 1 to 5.
Three hundred and sixty-eight responses were received. Most participants perceived exercise as important. Patients exercised three times per week for 30 min. Eighty percent endorsed walking (median response: 2—agree; IQR 1–2). Most did not jog, swim, cycle, or strength train. Fatigue, reported by 70%, was the major barrier (2, IQR 1–3). Over 90% of caregivers endorsed exercise as important (1—strongly agree, IQR 1–2) and encouraged exercise (median response 2, IQR 1–2). Over 60% of patients (median response 2, IQR 1–3) and caregivers (median response 2, IQR 2–3) felt providers encouraged exercise.
Patients and caregivers are willing to exercise to optimize physical fitness prior to liver transplantation.
Published guidelines do not address what the minimum incremental diagnostic yield (IDY) for detection of dysplasia/cancer is required over the standard Seattle protocol for an advanced imaging modality (AIM) to be implemented in routine surveillance of Barrett's esophagus (BE) patients. We aimed to report expert practice patterns and attitudes, specifically addressing the minimum IDY in the use of AIMs in BE surveillance.
An international group of BE experts completed an anonymous electronic survey of domains relevant to surveillance practice patterns and use of AIMs. The evaluated AIMs were conventional chromoendoscopy (CC), virtual chromoendoscopy (VC), volumetric laser endomicroscopy (VLE), confocal laser endomicroscopy (CLE), and wide-area transepithelial sampling (WATS3D). Responses were recorded using five-point balanced Likert items and analyzed as continuous variables.
The survey response rate was 84% (61/73)—41 US and 20 non-US. Experts were most comfortable with and routinely use VC and CC, and least comfortable with and rarely use VLE, CLE, and WATS3D. Experts rated data from randomized controlled trials (1.4 ± 0.9) and guidelines (2.6 ± 1.2) as the two most influential factors for implementing AIMs in clinical practice. The minimum IDY of AIMs over standard biopsies to be considered of clinical benefit was lowest for VC (15%, IQR 10–29%) and highest for VLE (30%, IQR 20–50%). Compared to US experts, non-US experts reported higher use of CC for BE surveillance (p < 0.001).
These results should inform benchmarks that need to be met for guidelines to recommend the routine use of AIMs in the surveillance of BE patients.
The Journal of Physiology, Volume 0, Issue ja, -Not available-.
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The Journal of Physiology, Volume 0, Issue ja, -Not available-.
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Pediatric Anesthesia, Volume 28, Issue 9, Page i-i, September 2018.
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Pediatric Anesthesia, Volume 28, Issue 9, Page 826-826, September 2018.
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Pediatric Anesthesia, Volume 28, Issue 9, Page 819-824, September 2018.
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Pediatric Anesthesia, Volume 28, Issue 9, Page 755-755, September 2018.
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Pediatric Anesthesia, Volume 28, Issue 9, Page 788-794, September 2018.
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Pediatric Anesthesia, Volume 28, Issue 9, Page ii-iv, 753, September 2018.
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Pediatric Anesthesia, Volume 28, Issue 9, Page 825-825, September 2018.
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Pediatric Anesthesia, Volume 28, Issue 9, Page 756-757, September 2018.
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Publication date: Available online 2 September 2018
Source: International Journal of Psychophysiology
Author(s): Jason S. Moser, Megan Fisher, Brian M. Hicks, Robert A. Zucker, C. Emily Durbin
The feedback negativity (FN) and reward positivity (RewP) are event-related brain potentials (ERPs) that follow the presentation of negative and positive feedback information, respectively, and have become the focus of recent research on psychopathology because of their associations with symptom severity of and risk for depression. We advanced our understanding of these feedback-related ERPs by examining developmental differences, familial transmission, and associations with error-monitoring ERPs. Parents and their children completed parallel, developmentally-tailored guessing and go/no-go tasks while feedback- and error-related ERPs were measured. We found that the Δ FN and RewP amplitudes increased with age and were larger in males than females among the child participants. The RewP also demonstrated familial transmission between fathers and their children. Finally, the FN and RewP were associated with error-related ERPs in children and adults, albeit in different ways. The current findings demonstrate that the FN and RewP have promise as developmentally-sensitive neural markers of reward and action monitoring processes associated with risk for psychopathology.
Psychological distress and mental illness has been found to be elevated in migrant groups living in sovereign countries, as well as for indigenous people living under colonial or administrative rule. The north Pacific island of Guam is unusual in its ethnic composition as it has no majority ethnic group, has a large indigenous population and remains a territory of the U.S. This study aimed to identify ethnic differences in self-reported psychological distress between the main ethnic groups on Guam. The study uses a cross sectional design with data linkage methodology, drawing on the Guam Census and the Behavioral Risk Factor Surveillance System health survey for Guam. The results showed that the native Chamorro population had worse self-reported psychological distress (defined as a 'mental health condition or emotional problem') than White/Caucasians (OR 2.09, 95% CI 1.52–2.87), particularly for severe distress (OR 3.61, 95% CI 1.33–2.77). This relationship persisted even after adjusting for a wide range of socio-demographic and economic factors (OR 2.58, 95% CI 1.15–5.76). Other Pacific Islanders also had higher psychological distress compared to White/Caucasians, but this association was largely explained by the adjusted factors. The findings are discussed in terms of social and economic disadvantage for Pacific Island peoples on Guam, as well as the impact of colonial administration, disaffection, and lack of autonomy for the Chamorro of Guam. Recommendations are made to improve psychiatric treatment for these groups by considering wider socio-political factors in assessment and treatment, as well as broader implications for the national dialogue on self-determination.