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Τρίτη 18 Οκτωβρίου 2016
Physical Activity and Pediatric Obesity: A Quantile Regression Analysis.
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Hip Biomechanics Are Altered in Male Runners with Achilles Tendinopathy.
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Mechanical effort predicts the selection of ankle over hip strategies in nonstepping postural responses
Experimental studies have shown that a continuum of ankle and hip strategies is used to restore posture following an external perturbation. Postural responses can be modeled by feedback control with feedback gains that optimize a specific objective. On the one hand, feedback gains that minimize effort have been used to predict muscle activity during perturbed standing. On the other hand, hip and ankle strategies have been predicted by minimizing postural instability and deviation from upright posture. It remains unclear, however, whether and how effort minimization influences the selection of a specific postural response. We hypothesize that the relative importance of minimizing mechanical work vs. postural instability influences the strategy used to restore upright posture. This hypothesis was investigated based on experiments and predictive simulations of the postural response following a backward support surface translation. Peak hip flexion angle was significantly correlated with three experimentally determined measures of effort, i.e., mechanical work, mean muscle activity and metabolic energy. Furthermore, a continuum of ankle and hip strategies was predicted in simulation when changing the relative importance of minimizing mechanical work and postural instability, with increased weighting of mechanical work resulting in an ankle strategy. In conclusion, the combination of experimental measurements and predictive simulations of the postural response to a backward support surface translation showed that the trade-off between effort and postural instability minimization can explain the selection of a specific postural response in the continuum of potential ankle and hip strategies.
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Age and Diet Affect Genetically Separable Secondary Injuries that Cause Acute Mortality Following Traumatic Brain Injury in Drosophila
Outcomes of traumatic brain injury (TBI) vary because of differences in primary and secondary injuries. Primary injuries occur at the time of a traumatic event, whereas secondary injuries occur later as a result of cellular and molecular events activated in the brain and other tissues by primary injuries. We used a Drosophila melanogaster TBI model to investigate secondary injuries that cause acute mortality. By analyzing percent mortality within 24 hours of primary injuries, we previously found that age at the time of primary injuries and diet afterward affect the severity of secondary injuries. Here, we show that secondary injuries peaked in activity 1-8 hours after primary injuries. Additionally, we demonstrate that age and diet activated distinct secondary injuries in a genotype-specific manner and that concurrent activation of age- and diet-regulated secondary injuries synergistically increased mortality. To identify genes involved in secondary injuries that cause mortality, we compared genome-wide mRNA expression profiles of uninjured and injured flies under age and diet conditions that had different mortalities. During the peak period of secondary injuries, innate immune response genes were the predominant class of genes that changed expression. Furthermore, age and diet affected the magnitude of the change in expression of some innate immune response genes, suggesting roles for these genes in inhibiting secondary injuries that cause mortality. Our results indicate that the complexity of TBI outcomes is due in part to distinct, genetically controlled, age- and diet-regulated mechanisms that promote secondary injuries and that involve a subset of innate immune response genes.
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First Description of KPC-2-Producing Escherichia coli and ST15 OXA-48-Positive Klebsiella pneumoniae in Tunisia
Microbial Drug Resistance , Vol. 0, No. 0.
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Acute Inflammatory Response of Patients with Pseudomonas aeruginosa Infections: A Prospective Study
Microbial Drug Resistance , Vol. 0, No. 0.
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Combination of Tigecycline and Levofloxacin for Successful Treatment of Nosocomial Pneumonia Caused by New Delhi Metallo-β-Lactamase-1-Producing Raoultella planticola
Microbial Drug Resistance , Vol. 0, No. 0.
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Laboratory-Based Surveillance of Extensively Drug-Resistant Tuberculosis in Eastern China
Microbial Drug Resistance , Vol. 0, No. 0.
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Cortical bone thickening in type a posterior atlas arch defects: experimental report
To date, no information about the cortical bone microstructural properties in atlas vertebrae with posterior arch defects has been reported.
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Risk of metastasis in adenocarcinoma of the esophagus: a multicenter retrospective study in a Japanese population
Abstract
Background
Little is known about the specific risks of metastasis in esophageal adenocarcinoma in relation to invasion depth or other pathologic factors.
Methods
We conducted a multicenter retrospective study in 13 high-volume centers in Japan from January 2000 to October 2014 to elucidate the risk of metastasis of esophageal adenocarcinoma. A total of 458 patients (217 surgically resected and 241 endoscopically resected) with esophageal adenocarcinoma or esophagogastric adenocarcinoma involving the esophagus were included. Metastasis was considered positive if there was histologically confirmed metastasis in the surgical specimen or clinically confirmed metastasis during follow-up. Metastasis was considered negative if no metastasis was identified in resected specimens and during follow-up in patients treated surgically or no metastasis during follow-up for >5 years in patients treated by endoscopic resection.
Results
Metastasis was identified in 72 patients. Multivariate analysis confirmed lymphovascular involvement [odds ratio (OR) 6.20; 95 % confidence interval (CI) 3.12–12.32; p < 0.001], a poorly differentiated component (OR 3.69; 95 % CI 1.92–7.10; p < 0.001), and lesion size >30 mm (OR 3.12; 95 % CI 1.63–5.97; p = 0.001) as independent risk factors for metastasis. No metastasis was detected in patients with mucosal cancer without lymphovascular involvement and a poorly differentiated component (0/186 lesions) or in patients with cancer invading the submucosa (1–500 µm) without lymphovascular involvement, a poorly differentiated component, and ≤30 mm (0/32 lesions).
Conclusions
Mucosal and submucosal cancers (1–500 µm invasion) without risk factors have a low incidence of metastasis and may thus be good candidates for endoscopic resection.
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Improved Pharmacokinetics Following PEGylation and Dimerization of a c(RGD-ACH-K) Conjugate Used for Tumor Positron Emission Tomography Imaging
Cancer Biotherapy & Radiopharmaceuticals Oct 2016, Vol. 31, No. 8: 295-301.
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The Roles of Mitochondria in Autophagic Cell Death
Cancer Biotherapy & Radiopharmaceuticals Oct 2016, Vol. 31, No. 8: 269-276.
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Targeting Gastrointestinal Stromal Tumor with 68Ga-Labeled Peptides: An In Vitro Study on Gastrointestinal Stromal Tumor-Cell Lines
Cancer Biotherapy & Radiopharmaceuticals Oct 2016, Vol. 31, No. 8: 302-310.
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Instruct Tact with RescueLift
Instructional video for the RescueLift Systems Tactical Litter.
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SAVE Video with RescueLift
RescueLift Systems was started by a EMS/flight paramedic looking to solve real world medical situations that arise on a daily basis and that may effect both the rescuer and patient.
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Instruct Tact with RescueLift
Instructional video for the RescueLift Systems Tactical Litter.
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SAVE Video with RescueLift
RescueLift Systems was started by a EMS/flight paramedic looking to solve real world medical situations that arise on a daily basis and that may effect both the rescuer and patient.
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Instruct Tact with RescueLift
Instructional video for the RescueLift Systems Tactical Litter.
from EMS via xlomafota13 on Inoreader http://ift.tt/2eizEG2
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SAVE Video with RescueLift
RescueLift Systems was started by a EMS/flight paramedic looking to solve real world medical situations that arise on a daily basis and that may effect both the rescuer and patient.
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Undiagnosed pulmonary sequestration results in an unexplained hemorrhagic shock in thoracoscopic pulmonary lobectomy
We report the first case of pulmonary sequestration which was not detected in the preoperative evaluation, resulting in a life-threatening hemorrhagic shock rapidly during the procedure of thoracoscopic pulmonary lobectomy. The anesthesiologists could not figure out the reason for the hemorrhagic shock in the surgery until an emergent laparotomy was performed. The aim of presenting this clinical case is to highlight the vigilance for undiagnosed pulmonary sequestration which lacks any specific clinical feature but has the potential to become an anesthetic disaster.
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Dose requirements of alfentanil to eliminate autonomic responses during rapid-sequence induction with thiopental 4 mg/kg and rocuronium 0.6 mg/kg
Opioids are integral part of anesthesia induction, but information on optimal dosing is limited. We aimed to determine doses of alfentanil needed to eliminate increases in 5 autonomic response variables (plasma concentrations of epinephrine, norepinephrine and vasopressin, arterial blood pressure [ABP], and heart rate) during rapid-sequence induction of anesthesia with thiopental 4 mg/kg and rocuronium 0.6 mg/kg.
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Glucagon-induced hypertensive emergency: a case report
Glucagon is well acknowledged as a sphincter of Oddi relaxant for both diagnostic and therapeutic uses in choledocholithiasis, and an empiric treatment for β-blocker overdose. Although it has been implicated in inducing cardiovascular crises in patients with asymptomatic pheochromocytoma, adverse effects in other patient populations have not been characterized. This case report describes a patient with hypertension controlled on β blockers who, after glucagon administration during an intraoperative cholangiography, experienced hypertensive emergency despite adequate pain control.
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C1-esterase inhibitor for short-term prophylaxis in a patient with hereditary angioedema with normal C1 inhibitor function
Hereditary angioedema with normal C1-esterase inhibitor (HAE-nC1INH) perioperative is a rare condition which could have potential disastrous ramifications for the anesthesiologist in the perioperative period. However, there is limited evidence and/or guidelines on the optimal way to manage these patients. We present the case of a patient with HAE-nC1INH who was successfully managed in the perioperative period with plasma derived C1-esterase inhibitor (pdC1INH). A 29-year-old woman with a diagnosis of HAE-nC1INH presented to the preoperative consultation in preparation for an upcoming total thyroidectomy.
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Cerebral oxygenation in the beach chair position for shoulder surgery in regional anesthesia: impact on cerebral blood flow and neurobehavioral outcome
Beach chair position is considered a potential risk factor for central neurological events particularly if combined with low blood pressure. The aim of this study was to assess the impact of regional anesthesia on cerebral blood flow and neurobehavioral outcome.
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Sugammadex given for rocuronium-induced neuromuscular blockade in infants: a retrospectıve study
To evaluate the efficacy and safety of sugammadex in reversing profound neuromuscular block induced by rocuronium in infant patients.
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The preoperative use of field tests of exercise tolerance to predict postoperative outcome in intra-abdominal surgery: a systematic review
To assess the ability of field tests of exercise tolerance, such as the 6-minute walk test (6MWT) and incremental shuttle walk test (ISWT), to predict postoperative outcome following intra-abdominal surgery.
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Children with heart disease: Risk stratification for non-cardiac surgery
Children with congenital or acquired heart disease have an increased risk of anesthesia related morbidity and mortality. The child's anesthetic risk is related to the severity of their underlying cardiac disease, associated comorbidities, and surgical procedure. The goal of this project was to determine the ease of use of a preoperative risk stratification tool for assigning pediatric cardiac staff and to determine the relative frequency that children with low, moderate, and high risk cardiac disease present for non-cardiac surgery at a tertiary pediatric hospital.
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Spine tumor resection among patients who refuse blood product transfusion: a retrospective case series
To describe the perioperative blood conservation strategies and postoperative outcomes in patients who undergo complex spinal surgery for tumor resection and who also refuse blood product transfusion.
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Erratum to “Efficacy of palonosetron in postoperative nausea and vomiting (PONV)—a meta-analysis” [J Clin Anesth 2016:34(459–482)]
The publisher regrets that the affiliation for Mahesh K. Arora, MD, was incorrectly displayed. Dr Arora's affiliation should read "Department of Anesthesia, All India Institute of Medical Sciences, New Delhi 110029, India."
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The effects of sevoflurane and desflurane on the hemodynamics and respiratory functions in laparoscopic sleeve gastrectomy
Sleeve gastrectomy has been one of the most commonly performed bariatric surgery methods. The study aimed to compare the effects of 2 most commonly used inhalation anesthetics, sevoflurane and desflurane, on the peroperative hemodynamic alterations and postoperative respiratory functions in morbidly obese patients undergoing sleeve gastrectomy.
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Lack of electrical interference between spinal cord stimulators and other implanted electrical pulse devices
Spinal cord stimulators (SCSs) have been used for decades to treat chronic pain. SCSs are often used to treat patients with chronic back pain caused by failed back surgery syndrome, patients with complex regional pain syndrome, or individuals who are not candidates for surgery. SCSs are a relative contraindication in patients with another electrical pulse device. We present 3 patients who received SCS despite having another implant in place. There was no interaction between devices. The first case was a patient with failed back surgery syndrome who had an implantable cardiac defibrillator and an SCS implant.
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Instruct Tact with RescueLift
Instructional video for the RescueLift Systems Tactical Litter.
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SAVE Video with RescueLift
RescueLift Systems was started by a EMS/flight paramedic looking to solve real world medical situations that arise on a daily basis and that may effect both the rescuer and patient.
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Improved Pharmacokinetics Following PEGylation and Dimerization of a c(RGD-ACH-K) Conjugate Used for Tumor Positron Emission Tomography Imaging
Cancer Biotherapy & Radiopharmaceuticals Oct 2016, Vol. 31, No. 8: 295-301.
from Mary Ann Liebert, Inc. publishers via xlomafota13 on Inoreader http://ift.tt/2eqpbHF
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The Roles of Mitochondria in Autophagic Cell Death
Cancer Biotherapy & Radiopharmaceuticals Oct 2016, Vol. 31, No. 8: 269-276.
from Mary Ann Liebert, Inc. publishers via xlomafota13 on Inoreader http://ift.tt/2dyyeZD
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Targeting Gastrointestinal Stromal Tumor with 68Ga-Labeled Peptides: An In Vitro Study on Gastrointestinal Stromal Tumor-Cell Lines
Cancer Biotherapy & Radiopharmaceuticals Oct 2016, Vol. 31, No. 8: 302-310.
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