Radiation Research, Volume 186, Issue 3, Page 323-323, September 2016.
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Παρασκευή 16 Σεπτεμβρίου 2016
Response to the “Letter to the Editor” by Dant, Stricklin and Millage on our Article: “Subject-Based versus Population- Based Care after Radiation Exposure”
Comments on “Subject-Based versus Population-Based Care after Radiation Exposure” by Yu et al. (Radiation Research 184, 46–55, 2015)
Radiation Research, Volume 186, Issue 3, Page 322-322, September 2016.
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Transcript Analysis for Internal Biodosimetry Using Peripheral Blood from Neuroblastoma Patients Treated with 131I-mIBG, a Targeted Radionuclide
Radiation Research, Volume 186, Issue 3, Page 235-244, September 2016.
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Differences in Radiation Dose Response between Small and Large Intestinal Crypts
Radiation Research, Volume 186, Issue 3, Page 302-314, September 2016.
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Extrapolation Ionization Chamber Dosimetry of Fluorescent X-Ray Energies from 4.5 to 19.6 keV
Radiation Research, Volume 186, Issue 3, Page 283-291, September 2016.
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MiR-29a Regulates Radiosensitivity in Human Intestinal Cells by Targeting PTEN Gene
Radiation Research, Volume 186, Issue 3, Page 292-301, September 2016.
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Metabolic Profile as a Potential Modifier of Long-Term Radiation Effects on Peripheral Lymphocyte Subsets in Atomic Bomb Survivors
Radiation Research, Volume 186, Issue 3, Page 275-282, September 2016.
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Nonlinear Radiation-Induced Cataract Using the Radiosensitive Ptch1+/– Mouse Model
Radiation Research, Volume 186, Issue 3, Page 315-321, September 2016.
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Simulating the Lunar Environment: Partial Weightbearing and High-LET Radiation-Induce Bone Loss and Increase Sclerostin-Positive Osteocytes
Radiation Research, Volume 186, Issue 3, Page 254-263, September 2016.
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Epidermal Growth Factor Attenuates Delayed Ionizing Radiation-Induced Tissue Damage in Bone Marrow Transplanted Mice
Radiation Research, Volume 186, Issue 3, Page 264-274, September 2016.
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An Integrated Multi-Omic Approach to Assess Radiation Injury on the Host-Microbiome Axis
Radiation Research, Volume 186, Issue 3, Page 219-234, September 2016.
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Radiobiological Effectiveness of Ultrashort Laser-Driven Electron Bunches: Micronucleus Frequency, Telomere Shortening and Cell Viability
Radiation Research, Volume 186, Issue 3, Page 245-253, September 2016.
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Winner -new Ambulance tender Norway: VW Amarok
"Volkswagen Amarok was simply the best in all categories, but yes, we were surprised even then it was left as the winner. The car has many advantages, -a good weight reserve, which means that there is a lot of weight to go on a stretcher, passengers, patients and equipment. -Very effective to load in and out of, and it is good for noise in the patient compartment, says project leader for procurement of Health Innkjøpsservice (PSHE), Kjetil Sønvis. Amarok won the tender in class less than 3.5 tonnes in competition with trotters as Volkswagen Caravelle. The cars are rebuilt in Finland, and can be run with regular certificate. All the cars get all-wheel drive and diesel engine. - However, had they been able to offer it, we had ordered some with 2 wheel drive and petrol engine too, he says. https://www.youtube.com/watch?v=cWoGzlTXQ9Y https://youtube/LN_WwgTo9As ExEMTNor
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Pneumatosis intestinalis during chemotherapy with nilotinib in a patient with chronic myeloid leukemia who tested positive for anti-topoisomerase I antibodies
Abstract
A 55-year-old man with several comorbidities including idiopathic interstitial pneumonia under long-term corticosteroid therapy, longstanding myocardial infarction, chronic heart failure, paroxysmal atrial fibrillation, gastro-esophageal reflux disease, constipation, and history of paralytic ileus, was diagnosed with chronic myelogenous leukemia (CML) in the chronic phase. He also tested positive for anti-topoisomerase I antibodies without clinical diagnosis of any connective tissue disease, including systemic sclerosis. Approximately 5 months after the initiation of nilotinib for CML, he developed upper abdominal distension with intermitting abdominal pain, and based on abdominal computed tomography findings, a diagnosis of pneumatosis intestinalis (PI) was made. Five courses of hyperbaric oxygen therapy quickly eliminated the PI and related symptoms without the cessation of nilotinib and, thereafter, additional oral prokinetic agents and non-absorbable antibiotics ensured the non-recurrence of PI. At 6 and 18 months after commencing nilotinib therapy, major and complete molecular response were achieved, respectively. It is suspected that both gastrointestinal hypokinesis related to the presence of anti-topoisomerase I antibodies and mucosal permeability due to corticosteroid therapy had existed. Thus, subsequent administration of nilotinib may have triggered PI by depressing gastrointestinal motility via the inhibition of c-kit.
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Winner -new Ambulance tender Norway: VW Amarok
"Volkswagen Amarok was simply the best in all categories, but yes, we were surprised even then it was left as the winner. The car has many advantages, -a good weight reserve, which means that there is a lot of weight to go on a stretcher, passengers, patients and equipment. -Very effective to load in and out of, and it is good for noise in the patient compartment, says project leader for procurement of Health Innkjøpsservice (PSHE), Kjetil Sønvis. Amarok won the tender in class less than 3.5 tonnes in competition with trotters as Volkswagen Caravelle. The cars are rebuilt in Finland, and can be run with regular certificate. All the cars get all-wheel drive and diesel engine. - However, had they been able to offer it, we had ordered some with 2 wheel drive and petrol engine too, he says. https://www.youtube.com/watch?v=cWoGzlTXQ9Y https://youtube/LN_WwgTo9As ExEMTNor
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Winner -new Ambulance tender Norway: VW Amarok
"Volkswagen Amarok was simply the best in all categories, but yes, we were surprised even then it was left as the winner. The car has many advantages, -a good weight reserve, which means that there is a lot of weight to go on a stretcher, passengers, patients and equipment. -Very effective to load in and out of, and it is good for noise in the patient compartment, says project leader for procurement of Health Innkjøpsservice (PSHE), Kjetil Sønvis. Amarok won the tender in class less than 3.5 tonnes in competition with trotters as Volkswagen Caravelle. The cars are rebuilt in Finland, and can be run with regular certificate. All the cars get all-wheel drive and diesel engine. - However, had they been able to offer it, we had ordered some with 2 wheel drive and petrol engine too, he says. https://www.youtube.com/watch?v=cWoGzlTXQ9Y https://youtube/LN_WwgTo9As ExEMTNor
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Two lost airways and one unexpected problem: undiagnosed tracheal stenosis in a morbidly obese patient
Anesthetic care of the morbidly obese is complex due to anatomic and physiologic alterations. Airway management in particular can be challenging. High body mass index is predictive of difficult ventilation and possibly difficult intubation. Other airway anomalies, such as tracheal stenosis, add to the complexity of airway management. Tracheal stenosis, a form of central airway obstruction, may be challenging to diagnose, especially in the obese. Comorbidities can mask the diagnosis and routine imaging may fail to identify the pathology.
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Effects of cerebellar theta-burst stimulation on arm and neck movement kinematics in patients with focal dystonia
Source:Clinical Neurophysiology
Author(s): Matteo Bologna, Giulia Paparella, Andrea Fabbrini, Giorgio Leodori, Lorenzo Rocchi, Mark Hallett, Alfredo Berardelli
ObjectiveTo investigate the cerebellar inhibitory influence on the primary motor cortex in patients with focal dystonia using a cerebellar continuous theta-burst stimulation protocol (cTBS) and to evaluate any relationship with movement abnormalities.MethodsThirteen patients with focal hand dystonia, 13 patients with cervical dystonia and 13 healthy subjects underwent two sessions: (i) cTBS over the cerebellar hemisphere (real cTBS) and (ii) cTBS over the neck muscles (sham cTBS). The effects of cerebellar cTBS were quantified as excitability changes in the contralateral primary motor cortex, as as well as possible changes in arm and neck movements in patients.ResultsReal cerebellar cTBS reduced excitability in the contralateral primary motor cortex in healthy subjects and in patients with cervical dystonia, though not in patients with focal hand dystonia. There was no correlation between changes in primary motor cortex excitability and arm and neck movement kinematics in patients. There were no changes in clinical scores or in kinematic measures, after either real or sham cerebellar cTBS in patients.ConclusionsThe reduced cerebellar inhibitory modulation of primary motor cortex excitability in focal dystonia may be related to the body areas affected by dystonia as opposed to being a widespread pathophysiological abnormality.SignificanceThe present study yields information on the differential role played by the cerebellum in the pathophysiology of different focal dystonias.
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Analysis of the impact of a cognitive task on the posture of elderly subjects with depression compared with healthy elderly subjects
Source:Clinical Neurophysiology
Author(s): Matthieu Casteran, Alain Putot, François Pfitzenmeyer, Elizabeth Thomas, Patrick Manckoundia
ObjectiveWhile previous studies have demonstrated that depressive elderly subjects (DES) experience difficulties in the processing of simultaneous cognitive tasks, few have examined the coupling of cognitive tasks with seemingly 'automatic' tasks, such as standing upright. Current patient management focuses on pharmacological treatments and cognitive-behavioral therapies.MethodsHealthy elderly (HES) and non-treated DES were included. Postural sway in DES was compared with that in HES while in single-task and dual-task conditions. The single-task consisted of standing upright. For the dual-task, the subjects recalled various items from memory or counted while standing upright. Postural sway was evaluated by computing the Center of Pressure (CoP) area and path length.ResultsDES showed greater postural sway than HES in all conditions. The HES showed a greater CoP area in the dual-task than in the single-task conditions. In DES, the CoP area in the single-task condition was similar to that in the dual-task condition.ConclusionsThe greater postural sway observed in DES may be a cause of a greater risk of falls. We showed that even seemingly automatic tasks, such as maintaining an upright posture, are affected by depression.SignificanceThese results are important for the management of DES.
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Peduncolopontine DBS improves balance in Progressive Supranuclear Palsy: Instrumental analysis
Source:Clinical Neurophysiology
Author(s): Carolina de Oliveira Souza, Andrea Cristina de Lima-Pardini, Daniel Boari Coelho, Rachael Brant, Eduardo Joaquim Lopes Alho, Ana Tereza Di Lorenzo Alho, Luis Augusto Teixeira, Manoel Jacobsen Teixeira, Egberto Reis Barbosa, Erich Talamoni Fonoff
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Motor Cortical Dysfunction Develops In Spinocerebellar Ataxia Type 3
Source:Clinical Neurophysiology
Author(s): Michelle A. Farrar, Steve Vucic, Garth Nicholson, Matthew C. Kiernan
ObjectiveSpinocerebellar ataxia type 3 (SCA3) is an inherited neurodegenerative disorder characterized by cerebellar ataxia and variable expression of clinical features beyond the cerebellum. To gain further insights into disease pathophysiology, the present study explored motor cortex function in SCA3 to determine whether cortical dysfunction was present and if this contributed to the development of clinical manifestations.MethodsClinical phenotyping and longitudinal assessments were combined with central (threshold-tracking transcranial magnetic stimulation) and peripheral (nerve excitability) techniques in 11 genetically characterized SCA3 patients.ResultsShort-interval intracortical inhibition was significantly reduced in presymptomatic and symptomatic SCA3 patients (-1.3±1.4%) compared to healthy controls (10.3±0.7%, P<0.0001), with changes evident prior to clinical onset of ataxia and related to worsening severity (R=-0.78, P<0.005). Central motor conduction time was also significantly prolonged in presymptomatic and symptomatic SCA3 patients (7.5±0.4ms) compared to healthy controls (5.3±0.2ms, P<0.0005) and related to clinical severity (R=0.81, P<0.005). Markers of peripheral motor neurodegeneration and excitability did not correlate with cortical hyperexcitability or ataxia.ConclusionsSimultaneous investigation of clinical status, and central and peripheral nerve function has identified progressive cortical dysfunction in SCA3 patients related to the development of ataxia.SignificanceThese findings suggest alteration in cortical activity is associated with SCA3 pathogenesis and neurodegeneration.
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OspTAC2 encodes a pentatricopeptide repeat protein and regulates rice chloroplast development
Publication date: Available online 15 September 2016
Source:Journal of Genetics and Genomics
Author(s): Dekai Wang, Heqin Liu, Guowei Zhai, Liangsheng Wang, Jianfeng Shao, Yuezhi Tao
Functional chloroplast generation depends on the precise coordination of gene expression between the plastid and the nucleus and is essential for plant growth and development. In this study, a rice (Oryza sativa) mutant that exhibited albino and seedling-lethal phenotypes was isolated from a 60Co-irradiated rice population. The mutant gene was identified as an ortholog of the Arabidopsis plastid transcriptionally active chromosome protein 2 (pTAC2) gene, and the mutant strain was designated osptac2. Sequence and transcription analyses showed that OspTAC2 encodes a putative chloroplast protein consisting of 10 pentratricopeptide repeat (PPR) domains and a C-terminal small MutS-related (SMR) domain. Cytological observations via microscopy showed that the OspTAC2-green fluorescent fusion protein was localized in the chloroplasts. Transmission electron microscopy revealed that the chloroplast of the osptac2 mutant lacks an organized thylakoid membrane. The transcript levels of all investigated PEP (plastid-encoded RNA polymerase)-dependent genes were dramatically reduced in the osptac2 mutant, whereas the transcript levels of NEP (nuclear-encoded polymerase)-dependent genes were increased. These results suggest that OspTAC2 plays a critical role in chloroplast development and indicate that the molecular function of the OspTAC2 gene is conserved in rice and Arabidopsis.
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Nonalcoholic fatty liver disease in Asia: emerging perspectives
Abstract
As in the West, nonalcoholic fatty liver disease (NAFLD) is the commonest chronic liver disease in Asia, with a prevalence higher than 40 % in some countries. The risk factors for NAFLD development are similar to those in Western countries, including increased body mass index, diabetes, insulin resistance, and metabolic syndrome. NAFLD in Asians is associated with different extrahepatic manifestations involving the cardiovascular, gastrointestinal, and renal systems. A considerable proportion of Asians with NAFLD are described as having "lean" NAFLD. Present in approximately 20 % of the Asian population, lean NAFLD is closely linked with insulin resistance, diabetes, and other metabolic complications, but its association with disease progression to nonalcoholic steatohepatitis and cirrhosis remains to be defined. There is emerging evidence of the interactions of NAFLD with hepatitis B virus and hepatitis C virus infection in Asia. Unlike in Western countries, NAFLD constitutes only a minority of cirrhosis and hepatocellular carcinoma cases in Asia. Possible explanations are the lower prevalence of obesity and the overwhelming problem of viral hepatitis in Asia. With aging of the obesity cohort in Asia, NAFLD-related liver complications are expected to increase.
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Body armor for EMS: 4 success tips to fund through AFG
Ballistic protective equipment for active shooter response is eligible for Assistance to Firefighters grant funding.
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Body armor for EMS: 4 success tips to fund through AFG
As of April 10, 2014 fire departments and EMS agencies are able to apply for grant funding through the Homeland Security Grant Program and Tribal Homeland Security Grant Program to purchase ballistic protective equipment for fire/rescue and EMS personnel.
Ballistic protective equipment is for response to active shooter and mass casualty incidents to support the entry of EMS personnel into a warm zone for triage, treatment and extrication of the wounded. However, like many federal grants, the HSGP is extremely competitive, especially since fire and EMS agencies are competing against police departments for a limited amount of funding.
To mitigate the funding limitations and competitiveness of the HSGP, the Assistance to Firefighters Grant has made Ballistic Protective Equipment eligible as a new mission under personal protective equipment. BPE is to include one vest, one helmet, one triage bag and one pair of goggles. This is considered specialized PPE and of medium priority.
Read full story on EMSGrantsHelp.com
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Study of body mass index in first year MBBS students in a medical college of Eastern UP
2016-09-16T09-01-29Z
Source: International Journal of Medical Science and Public Health
Sarita Agrawal, Vivek Sinha, Poonam Kachhawa, Arun Kumar.
Background: Overweight and obesity are recognized as escalating epidemics affecting both developed and developing countries. Obesity is associated with a large number of debilitating and life-threatening disorders such as cardiovascular, metabolic, and other non-communicable diseases. Of the factors contributing to obesity, stress seems to be particularly important as stressful condition leads to irregularity in diet, lack of exercise and addiction, each being considered an independent factor leading to obesity. Medical students are exposed to a lot of stress throughout their education. Hence, this study was undertaken to find out the prevalence of overweight and obesity among undergraduate medical students. Objectives: To assess the prevalence of overweight and obesity among medical students in Saraswati Institute of Medical Sciences, Hapur, Uttar Pradesh and also to find the relationship of the following risk factors with obesity: (a) physical inactivity, (b) sleeping habits, (c) diet, (d) stress, and (e) association with other diseases (thyroid disorders, menstrual disorders). Material and Methods: A descriptive cross-sectional survey was conducted in the Department of Biochemistry among 100 students; data were collected using pretested questionnaire from 100 students after taking an informed consent. The height and weight of the students were measured, and the BMI was calculated. Results: Among the 100 students, the mean ± SD height of the students was 1.67 ± 0.09 m, while the mean weight was 66.61 ± 12.71 kg and the mean BMI 23.54 ± 3.09 kg/m2. Normal BMI was observed in 73.1% students, while 22.3% students were overweight, 3.1% obese, and only, 1.5% underweight. Overweight and obesity were significantly more in male than female students. Conclusion: The present study gives an idea about the high prevalence of overweight and obesity in the medical students. There is a need to create awareness and interest regarding healthy diet and body weight management among this future physician population. Nutritional education on dietary practices and life style change should be built in as supporting educational activity during student years.
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Line-of-duty death and injury prevention
It is possible to have zero injuries and deaths from ambulance collisions. A zero accident attitude — or ZAA! — is based on every responder following safe driving practices.
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Resolve to be personally prepared anytime of year
Check out these four tools that help individuals and families carry proper medical history and contact info at all times.
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Holiday safety tips for EMS providers to share with friends and family
As you interact with the community this holiday season, remember to remind them of these simple yet important seasonal safety tips.
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EMS promotion of helmets for snow sports
Getting kids to wear protective gear is not an easy task. Try these methods to promote helmet use among the little ones.
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