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Clinical Thyroidology, Volume 30, Issue 3, Page 135-137, March 2018.
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Clinical Thyroidology, Volume 30, Issue 3, Page 122-125, March 2018.
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Clinical Thyroidology, Volume 30, Issue 3, Page 129-131, March 2018.
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Clinical Thyroidology, Volume 30, Issue 3, Page 104-107, March 2018.
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Clinical Thyroidology, Volume 30, Issue 3, Page 108-111, March 2018.
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Clinical Thyroidology, Volume 30, Issue 3, Page 100-103, March 2018.
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Clinical Thyroidology, Volume 30, Issue 3, Page 112-114, March 2018.
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Clinical Thyroidology, Volume 30, Issue 3, Page 126-128, March 2018.
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Clinical Thyroidology, Volume 30, Issue 3, Page 115-118, March 2018.
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Clinical Thyroidology, Volume 30, Issue 3, Page 132-134, March 2018.
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Clinical Thyroidology, Volume 30, Issue 3, Page 119-121, March 2018.
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Clinical Thyroidology, Volume 30, Issue 3, Page 138-141, March 2018.
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Electronic health records and other reporting tools from ESO Solutions helped streamline documentation at a pioneering Florida agency
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Coconuts (Cocos nucifera L.) are divided by the height into tall and dwarf types. In many plants the short phenotype was emerged by mutation of the GA20ox gene encoding the enzyme involved in gibberellin (GA) biosynthesis. Two CnGA20ox genes, CnGA20ox1 and CnGA20ox2, were cloned from tall and dwarf types coconut. The sequences, gene structures and expressions were compared. The structure of each gene comprised three exons and two introns. The CnGA20ox1 and CnGA20ox2 genes consisted of the coding region of 1110 and 1131 bp, encoding proteins of 369 and 376 amino acids, respectively. Their amino acid sequences are highly homologous to GA20ox1 and GA20ox2 genes of Elaeis guineensis, but only 57% homologous to each other. However, the characteristic amino acids two histidines and one aspartic acid which are the two iron (Fe2+) binding residues, and arginine and serine which are the substrate binding residues of the dioxygenase enzyme in the 20G-FeII_Oxy domain involved in GA biosynthesis, were found in the active site of both enzymes. The evolutionary relationship of their proteins revealed three clusters in vascular plants, with two subgroups in dicots and three subgroups in monocots. This result confirmed that CnGA20ox was present as multi-copy genes, and at least two groups CnGA20ox1 and CnGA20ox2 were found in coconut. The nucleotide sequences of CnGA20ox1 gene in both coconut types were identical but its expression was about three folds higher in the leaves of tall coconut than in those of dwarf type which was in good agreement with their height. In contrast, the nucleotide sequences of CnGA20ox2 gene in the two coconut types were different, but the expression of CnGA20ox2 gene could not be detected in either coconut type. The promoter region of CnGA20ox1 gene was cloned, and the core promoter sequences and various cis-elements were found. The CnGA20ox1 gene should be responsible for the height in coconut, which is different from other plants because no mutation was present in CnGA20ox1 gene of dwarf type coconut.
Psychophysiology, Ahead of Print.
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A 34-year-old woman visited our hospital for treatment of a huge splenic cyst with epigastric pain. She had been diagnosed with Gaucher's disease (Type 1) at 3 years of age and had been receiving enzyme replacement therapy (ERT) from 15 years of age. Abdominal MRI showed a low-intensity area, 30 cm in diameter, with a well-defined border on T1-weighted images. The patient underwent laparoscopic fenestration of the huge splenic cyst for relief of worsening epigastric pain caused by the cyst. The cyst contained 2,500 ml of brownish-red fluid. The patient recovered satisfactorily and was discharged on postoperative day 11. Gaucher's disease is an extremely rare metabolic disease; only about 6,000 patients are registered in the International Collaborative Gaucher Group Gaucher Registry. An extremely rare case of a huge symptomatic splenic cyst treated by laparoscopic fenestration in a patient with Gaucher's disease is described.
Association mapping based on linkage disequilibrium provides a promising tool for dissecting the genetic basis underlying complex traits. To reveal the genetic variations of yield and yield components traits in upland cotton, 403 upland cotton accessions were collected and analyzed by 560 genome-wide simple sequence repeats (SSRs). A diverse panel consisting of 403 upland cotton accessions was grown in six different environments, and the yield and yield component traits were measured, and 560 SSR markers covering the whole genome were mapped. Association studies were performed to uncover the genotypic and phenotypic variations using a mixed linear model. Favorable alleles and typical accessions for yield traits were identified. A total of 201 markers were polymorphic, revealing 394 alleles. The average gene diversity and polymorphism information content were 0.556 and 0.483, respectively. Based on a population structure analysis, 403 accessions were divided into two subgroups. A mixed linear model analysis of the association mapping detected 43 marker loci according to the best linear unbiased prediction and in at least three of the six environments(− lgP > 1.30, P < 0.05). Among the 43 associated markers, five were associated with more than two traits simultaneously and nine were coincident with those identified previously. Based on phenotypic effects, favorable alleles and typical accessions that contained the elite allele loci related to yield traits were identified and are widely used in practical breeding. This study detected favorable quantitative trait loci's alleles and typical accessions for yield traits, these are excellent genetic resources for future high-yield breeding by marker-assisted selection in upland cotton in China.
Consider incorporating this diagnostic tool into firefighter physicals to support early diagnosis and intervention that can save lives
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Asian Journal of Endoscopic Surgery, Ahead of Print.
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Functional near infrared spectroscopy (fNIRS) finds extended applications in a variety of neuroscience fields. We investigated the potential of fNIRS to monitor voluntary engagement of users during neurorehabi...
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Published reports suggest a disparity between perceived and actual balance abilities, a trait associated with increased fall-risk in older adults. We investigate whether it is possible to 'recalibrate' these d...
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It will be challenge to find a replacement, state officials said, but they are working on it
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Habitual consumption of chlorogenic acid compounds (CGAs) from coffee increases fat catabolism and reduces body fat; however, the contribution of roasted coffee remains unclear. Hydroxyhydroquinone (HHQ) impairs the vasodilatory and antihypertensive effects of CGAs by reducing nitric oxide (NO) bioavailability. Since HHQ also reduces fat catabolism, we hypothesized that HHQ does so by decreasing NO availability. Therefore, we investigated the effect of HHQ on energy metabolism in KKAy mice. In HHQ-treated mice, fat oxidation was significantly low and dose-dependent, serum and urinary hydrogen peroxide were high, and plasma NO metabolites and S-nitrosylated liver proteins were low. In HHQ-treated mouse hepatocytes, the palmitate-induced increase in cellular oxygen consumption was negatively affected, and HHQ or L-NAME reduced cellular fatty acid utilization. In conclusion, HHQ can impair fat utilization by reducing NO availability in mice. Protein S-nitrosylation reduction in liver cells after HHQ consumption may be associated with impaired fatty acid oxidation.
Publication date: Available online 22 March 2018
Source:International Journal of Psychophysiology
Author(s): José Francisco Tornero-Aguilera, Vicente Javier Clemente-Suárez
The present study aimed to analyze the effect of underground operations on the psychophysiological and memory response of soldiers taking into consideration experience, the use of nocturne vision systems and previous combat actions on the psychophysiological response. Seventy participants were recruited and divided in four groups, three experimental groups with different experimental conditions, SNFV (Soldiers No-Fire Night-Vision), SFV (Soldiers Fire Night-Vision), SNFNV (Soldiers No-Fire No Night-Vision), and one control group, CNFV (Control No-Fire Night-Vision). We analyzed modifications in psychophysiological and memory response pre and post an underground operation. The underground operation produced a significant increase (p < 0.05) in blood lactate, blood oxygen saturation, rated perceived exertion, heart rate, cognitive and somatic anxiety and sympathetic modulation in all groups. Groups with higher stress values scored higher incorrect items in the memory post mission questionnaire. The higher psychophysiological activation correlated positively with cognitive impairment and lower memory. We concluded that an underground operation produced an increase in psychophysiological activation and a negative effect on memory, being modulated by previous training and experience. The lack of special equipment as night vision systems in underground operations induced similar stress response than prior combat actions, decreasing conciseness of time.
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Rocuronium and propofol are used in the induction of anesthesia give discomfort to the patients. We aimed to investigate the relationship between venous diameter measured using ultrasonography, and pain and withdrawal movements after propofol and rocuronium applied with intravenous (IV).
This prospective-observational study was performed on 142 voluntary patients undergoing surgical operation under general anesthesia. An ultrasonography was used to measure the vein transverse diameter. Patients with a venous transverse diameter of ≤2 mm were classified as group 1 (n = 50), while patients with a diameter of > 2 mm were classified as group 2 (n = 92). The propofol pain was assessed according to the verbal rating scale (VRS). In addition, the withdrawal movements of the rocuronium injection were evaluated using the four-point scale.
There was no difference between the two groups in terms of the demographic data. The patients have pain after propofol 38.2% and withdrawal movements after rocuronium 42.4% were detected. The maximum number of patients without pain after propofol injection (78.2%) and without withdrawal movements after rocuronium (76%) was found to be higher in group 2 (p = 0.001).
In this study, we found a reduction in the incidence and severity of pain and withdrawal movements in intravenous propofol and rocuronium administration through peripheral venous vessels of large diameter. We believe that the clinical drug injection through vessels with large venous diameter with the help of USG may be a non-invasive, simple, and reliable method to reduce pain and withdrawal movements in propofol and rocuronium injections.
Surveys tend to yield low response rates among human service professionals. This study examined whether a randomly-assigned prepaid $2 incentive increased response rates over time, and was cost-effective for increasing response count, among social workers and volunteer mediators. The incentive was enclosed with a mixed-mode survey of factors related to burnout and intention-to-remain. The incentive increased response rates over time. The effect of the incentive did not differ between mediators and social workers. The $2 incentive was not cost-effective for increasing response count. Implications are discussed for reducing nonresponse bias, decreasing time-to-response, and considering response rate versus response count.
In 10–15% of the cases, conventional methods for removing bile duct stones by ERCP/balloon-basket extraction fail. The purpose of this review is to describe endoscopic techniques in managing these "difficult bile duct stones."
Endoscopic papillary large balloon dilation with balloon extraction ± mechanical lithotripsy is the initial approach used to retrieve large bile duct stones. With advent of digital cholangioscopy, electrohydraulic and laser lithotripsy are gaining popularity. Enteroscopy-assisted or laparoscopic-assisted approaches can be used for those with gastric bypass anatomy.
Difficulties in removing bile duct stones can be related to stone-related factors such as the size and location of the stone or to altered anatomy such as stricture in the bile duct or Roux-en-Y anatomy. Several endoscopy approaches and techniques have described in the recent past that have greatly enhanced our ability to remove these "difficult" bile duct stones.