Purpose To determine the role of noradrenergic modulation in the control of motor output, we compared the acute effect of Reboxetine (REB), a noradrenaline reuptake inhibitor, to a placebo (PLA) on knee extensors motor performance and cortical and spinal excitability. Methods Eleven young males took part in two randomized experiments during which they received either 8 mg of REB or a PLA. The torque produced during a maximal voluntary contraction (MVC) and its variability (i.e. coefficient of variation) during submaximal contractions ranging from 5 to 50% MVC were measured. Paired electrical (PES) and transcranial magnetic stimulation (TMS) were used to assess changes in voluntary activation during MVC, and corticospinal (motor evoked potential - MEP) and spinal excitability (Hoffman (H) reflex) during contraction at 20% MVC. Results MVC torque and torque steadiness increased respectively by 9.5 and 24% on average in REB compared with PLA condition (P
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