Τρίτη, 2 Οκτωβρίου 2018

Cardiorespiratory Fitness, Adiposity, and Heart Rate Variability: The CARDIA Study

Purpose The importance of cardiorespiratory fitness vs. adiposity in determining heart rate variability (HRV) is unclear. Methods From CARDIA, an observational cohort study, we included 2,316 participants (mean age 45.2±3.6 years at Year 20, 57% female, 43% black) with HRV measured in 2005–06 (Year 20), and graded exercise test duration (GXTd) and adiposity measures (BMI, waist circumference) obtained in 1985–86 (baseline) and 2005–06. HRV measures (standard deviation of all normal RR intervals [SDNN] and square root of the mean of the squares of differences between all successive RR intervals [RMSSD]) were obtained from resting 30-second 12-lead ECGs. Cross-sectional associations between GXTd, adiposity and HRV were assessed at Year 20. Longitudinal changes in GXTd and adiposity measures were categorized as ≥10% increase,

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Efflux Pump Inhibitors, Alpha-Tocopherol and Aspirin: Role in Campylobacter jejuni and Campylobacter coli Fluoroquinolone Resistance

Microbial Drug Resistance, Ahead of Print.


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First Report of Extended-Spectrum Betalactamase-Producing Klebsiella pneumoniae Among Fecal Carriage in Iran: High Diversity of Clonal Relatedness and Virulence Factor Profiles

Microbial Drug Resistance, Ahead of Print.


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Utilization of Chemical Deposition Technique for Preparation of Miniature 170Tm Sources and Preliminary Quality Assessment for Potential Use in Brachytherapy

Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.


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PIE-1 Translation in the Germline Lineage Contributes to PIE-1 Asymmetry in the Early Caenorhabditis elegans Embryo

In the C. elegans embryo, the germline lineage is established through successive asymmetric cell divisions that each generate a somatic and a germline daughter cell. PIE-1 is an essential maternal factor that is enriched in embryonic germline cells and is required for germline specification. We estimated the absolute concentration of PIE-1::GFP in germline cells and find that PIE-1::GFP concentration increases by roughly 4.5 fold, from 92 nM to 424 nM, between the 1 and 4-cell stages. Previous studies have shown that the preferential inheritance of PIE-1 by germline daughter cells and the degradation of PIE-1 in somatic cells are important for PIE-1 enrichment in germline cells. In this study, we provide evidence that the preferential translation of maternal PIE-1::GFP transcripts in the germline also contributes to PIE-1::GFP enrichment. Through an RNAi screen, we identified Y14 and MAG-1 (Drosophila tsunagi and mago nashi) as regulators of embryonic PIE-1::GFP levels. We show that Y14 and MAG-1 do not regulate PIE-1 degradation, segregation or synthesis in the early embryo, but do regulate the concentration of maternally-deposited PIE-1::GFP. Taken together, or findings point to an important role for translational control in the regulation of PIE-1 levels in the germline lineage.



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Physical basis for long-distance communication along meiotic chromosomes [Genetics]

Viable gamete formation requires segregation of homologous chromosomes connected, in most species, by cross-overs. DNA double-strand break (DSB) formation and the resulting cross-overs are regulated at multiple levels to prevent overabundance along chromosomes. Meiotic cells coordinate these events between distant sites, but the physical basis of long-distance chromosomal communication has...

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Behavior of homing endonuclease gene drives targeting genes required for viability or female fertility with multiplexed guide RNAs [Genetics]

A gene drive method of particular interest for population suppression utilizes homing endonuclease genes (HEGs), wherein a site-specific, nuclease-encoding cassette is copied, in the germline, into a target gene whose loss of function results in loss of viability or fertility in homozygous, but not heterozygous, progeny. Earlier work in Drosophila...

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Parp3 promotes long-range end joining in murine cells [Genetics]

Chromosomal rearrangements, including translocations, are early and essential events in the formation of many tumors. Previous studies that defined the genetic requirements for rearrangement formation have identified differences between murine and human cells, most notably in the role of classic and alternative nonhomologous end-joining (NHEJ) factors. We reported that poly(ADP)ribose...

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Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA [Genetics]

Ribosome biogenesis is a multistep process, during which mistakes can occur at any step of pre-rRNA processing, modification, and ribosome assembly. Misprocessed rRNAs are usually detected and degraded by surveillance machineries. Recently, we identified a class of antisense ribosomal siRNAs (risiRNAs) that down-regulate pre-rRNAs through the nuclear RNAi pathway. To...

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Comments on Doguet et al. (2017) ‘Muscle length effect on corticospinal excitability during maximal concentric, isometric and eccentric contractions of the knee extensors’

Experimental Physiology, Volume 103, Issue 10, Page 1435-1436, 1 October 2018.


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Editorial Board

Experimental Physiology, Volume 103, Issue 10, Page 1439-1442, 1 October 2018.


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Ariz. fire dept. responders to be equipped with body armor

The Mesa City Council voted to spend $262,000 on body armor for firefighters and paramedics

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Putting genetic variants to a fitness test

Putting genetic variants to a fitness test

Putting genetic variants to a fitness test, Published online: 02 October 2018; doi:10.1038/s41576-018-0056-4

Two studies report the application of high-throughput genome editing approaches to engineer many precise genetic variants and determine their functional impact in human and yeast cells.

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Metabolic syndrome and the incidence of hepatocellular carcinoma: A meta-analysis of cohort studies

OncoTargets and Therapy

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Gastric cancer with synchronous and metachronous hepatic metastasis predicted by enhancement pattern on multiphasic contrast-enhanced CT

European Journal of Radiology

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Prognostic factors of disease-free and overall survival in patients with hepatocellular carcinoma undergoing partial hepatectomy in curative intent

Langenbeck's Archives of Surgery

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Risk of hepatocellular carcinoma in patients treated with entecavir vs tenofovir for chronic hepatitis B: A Korean nationwide cohort study

JAMA Oncology

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Putting genetic variants to a fitness test



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Brain correlates of stress‐induced peripheral vasoconstriction in patients with cardiovascular disease

Psychophysiology, EarlyView.


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First data from a parent‐reported registry of 81 individuals with Coffin–Siris syndrome: Natural history and management recommendations

American Journal of Medical Genetics Part A, EarlyView.


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Association of hypocalcemia with congenital heart disease in 22q11.2 deletion syndrome

American Journal of Medical Genetics Part A, EarlyView.


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Multicenter study of mortality in achondroplasia

American Journal of Medical Genetics Part A, EarlyView.


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Congenital lumbar hernia–A feature of diabetic embryopathy?

American Journal of Medical Genetics Part A, EarlyView.


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Issue Information

The Journal of Physiology, Volume 596, Issue 19, Page 4549-4550, 1 October 2018.


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