Τρίτη 2 Οκτωβρίου 2018

Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA [Genetics]

Ribosome biogenesis is a multistep process, during which mistakes can occur at any step of pre-rRNA processing, modification, and ribosome assembly. Misprocessed rRNAs are usually detected and degraded by surveillance machineries. Recently, we identified a class of antisense ribosomal siRNAs (risiRNAs) that down-regulate pre-rRNAs through the nuclear RNAi pathway. To...

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