Τρίτη 2 Οκτωβρίου 2018

Parp3 promotes long-range end joining in murine cells [Genetics]

Chromosomal rearrangements, including translocations, are early and essential events in the formation of many tumors. Previous studies that defined the genetic requirements for rearrangement formation have identified differences between murine and human cells, most notably in the role of classic and alternative nonhomologous end-joining (NHEJ) factors. We reported that poly(ADP)ribose...

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