Τετάρτη, 28 Σεπτεμβρίου 2016
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2dBv0TD
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2dFg9u2
Kilohertz and Low-Frequency Electrical Stimulation With the Same Pulse Duration Have Similar Efficiency for Inducing Isometric Knee Extension Torque and Discomfort.
from Rehabilitation via xlomafota13 on Inoreader http://ift.tt/2dbVLOi
Perceived Exertion Is Lower When Using a Functional Electrical Stimulation Neuroprosthesis Compared With an Ankle-Foot Orthosis in Persons With Multiple Sclerosis: A Preliminary Study.
from Rehabilitation via xlomafota13 on Inoreader http://ift.tt/2dbUfvL
Dissociating parafoveal preview benefit and parafovea-on-fovea effects during reading: A combined eye tracking and EEG study
During reading, the parafoveal processing of an upcoming word n+1 can influence word recognition in two ways: It can affect fixation behavior during the preceding fixation on word n (parafovea-on-fovea effect, POF), and it can facilitate subsequent foveal processing once word n+1 is fixated (preview benefit). While preview benefits are established, evidence for POF effects is mixed. Recently, it has been suggested that POF effects exist, but have a delayed impact on saccade planning and thus coincide with preview benefits measured on word n+1. We combined eye movement and EEG recordings to investigate and separate neural correlates of POF and preview benefit effects. Participants read lists of nouns either in a boundary paradigm or the RSVP-with-flankers paradigm, while we recorded fixation- or event-related potentials (FRPs/ERPs), respectively. The validity and lexical frequency of the word shown as preview for the upcoming word n+1 were orthogonally manipulated. Analyses focused on the first fixation on word n+1. Preview validity (correct vs. incorrect preview) strongly modulated fixation times and electrophysiological N1 amplitudes, replicating previous findings. Importantly, gaze durations and FRPs measured on word n+1 were also affected by the frequency of the word shown as preview, with low-frequency previews eliciting a sustained, N400-like centroparietal negativity. Results support the idea that POF effects exist but affect word recognition with a delay. Lastly, once word n+1 was fixated, its frequency also modulated N1 amplitudes in ERPs and FRPs. Taken together, we separated immediate and delayed effects of parafoveal processing on brain correlates of word recognition.
from Physiology via xlomafota13 on Inoreader http://ift.tt/2d6rtO1
14-3-3 proteins are pSer/pThr-binding proteins that interact with a wide array of cellular 'client' proteins. The plant brassinosteroids (BRs) receptor, BRASSINOSTEROID INSENSITIVE 1 (BRI1), is a member of the large family of leucine-rich repeat receptor-like kinases (LRR-RLKs) that contain cytoplasmic protein kinase domains. At least two LRR-RLKs are involved in BR perception and signal transduction: BRI1 and BRI1-associated receptor kinase 1 (BAK1). We determined that several 14-3-3 proteins bind to BRI1-CD and are phosphorylated by BRI1, BAK1 and At3g21430 receptor kinases in vitro. Moreover, we observed14-3-3 s are phosphorylated on threonine residue(s) with BR-dependent manner. To reveal the function of 14-3-3 proteins interacting with LRR-RLKs, we treated tyrosine phosphatase (PTP1B) to the BRI1-CD recombinant protein, which is autophosphorylated on tyrosine residue(s). Tyrosine autophosphorylation signal was disappeared, suggesting that 14-3-3 proteins cannot protect BRI1 tyrosine phosphorylation from PTP1B phosphatase. Our study suggests that 14-3-3 proteins may be important for plant growth and development through BR signaling.
from Genetics via xlomafota13 on Inoreader http://ift.tt/2dmLZaL
A six-CpG panel with DNA methylation biomarkers predicting treatment response of chemoradiation in esophageal squamous cell carcinoma
Prognosis of esophageal squamous cell carcinoma (ESCC) patients remains poor, and the chemoradiotherapy (CRT) applied to ESCC patients often failed. Therefore, development of biomarkers to predict CRT response is immensely important for choosing the best treatment strategy of an individual patient.
The methylation array and pyrosequencing methylation assay were performed in pre-treatment endoscopic biopsies to identify probes with differential CpG methylation levels between good and poor CRT responders in a cohort of 12 ESCC patients. Receiver operating characteristic curves and multivariate logistic regressions were conducted to build the risk score equation of selected CpG probes in another cohort of 91 ESCC patients to predict CRT response. Kaplan–Meier analysis was used to estimate progression-free survival or time-to-progression of patients predicted with good and poor CRT responses.
Nine differentially methylated CpG probes were identified to be associated with CRT response. A risk score equation comprising six CpG probes located in IFNGR2, KCNK4, NOTCH4, NPY, PAX6, and SOX17 genes were built. The risk score was derived from the sum of each probe multiplied by its corresponding coefficient. Such a risk score has a good prediction performance in discriminating poor CRT responders from good responders (AUC: 0.930). Moreover, poor CRT responders predicted by risk score significantly had poorer prognosis in terms of shorter progression-free survival and time-to-progression (p = 0.004–0.008).
We established a proof-of-concept CRT response prediction panel consisting of six-CpG methylation biomarkers in identifying ESCC patients who are at high risk of CRT failure and need intensive care.
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2cB4Ca3
Validation of the EORTC QLQ-BIL21 questionnaire for measuring quality of life in patients with cholangiocarcinoma and cancer of the gallbladder
British Journal of Cancer
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2d8M1pF
BMC Infectious Diseases
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2dyOVlK
Ludwig Institute for Cancer Research News
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2d8MpVl
Anti-cancer activity of Psoralea Fructus through the downregulation of cyclin D1 and CDK4 in human colorectal cancer cells
BMC Complementary and Alternative Medicine
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2dyNvIe
Long-term outcomes of bariatric and metabolic surgery in Japan: Results of a multi-institutional survey
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2d8Mp7O
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2dyMZtA
A highly predictive model for diagnosis of colorectal neoplasms using plasma MicroRNA: Improving specificity and sensitivity
Annals of Surgery
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2d8Lwfs
Inefficacy of triple therapy and comparison of two different bismuth-containing quadruple regimens as a firstline treatment option for helicobacter pylori
Saudi Journal of Gastroenterology
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2dyLCLF
Changes in blood microbiota profiles associated with liver fibrosis in obese patients: A pilot analysis
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2d8LiVx
Alginate therapy is effective treatment for gastroesophageal reflux disease symptoms: A systematic review and meta-analysis
Diseases of the Esophagus
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2dyMXls
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2d8LYtZ
Patients with HBV-related acute-on-chronic liver failure have increased concentrations of extracellular histones aggravating cellular damage and systemic inflammation
Journal of Viral Hepatitis
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2dyNwvT
Crohn’s disease activity and concomitant immunosuppressants affect the risk of serious and opportunistic infections in patients treated with adalimumab
The American Journal of Gastroenterology
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2d8LPXJ
Journal of the American Geriatrics Society
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2dyMfoh
Results of a pooled analysis of IOERT containing multimodality treatment for locally recurrent rectal cancer
European Journal of Surgical Oncology
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2d8Mw3m
Cost averted with timely fecal microbiota transplantation in the management of recurrent clostridium difficile infection in alberta, canada
Journal of Clinical Gastroenterology
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2dyLxYn
Semi-quantitative assessment of the presence and Child–Pugh class of hepatitis B related cirrhosis by using liver lobe-based dynamic contrast-enhanced MRI
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2d8MloA
Liver resection and transplantation for patients with hepatocellular carcinoma beyond Milan criteria
Annals of Surgery
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2dyNy6K
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2d8MiZW
Liver transplantation in transthyretin amyloidosis: Characteristics and management related to kidney disease
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2d94h0J