Neurodegenerative diseases significantly alter the gait dynamics and, hence, various gait parameters. In this paper, we present results of a comprehensive statistical analysis of the gait time parameters, namely swing interval, stance interval, stride interval, and double support interval, in healthy individuals and patients suffering from neurodegenerative diseases (Huntington's, HD, Parkinson's, PD, and amyotrophic lateral sclerosis, ALS). Multivariate analysis of variance (MANOVA) along with other tests, including univariate tests, post-hoc tests, and discriminant analysis, were employed in this study. Results of discriminant analysis demonstrated that the groups differed significantly from each other with respect to the dependent variables (P < 0.05). All the variables had a strong positive relationship with the first variate or factor, and the left swing, right swing, right stride, and left stride had a positive relationship with the second variate; the double support had a negative relationship. Results of our analyses provide a direction for the selection of certain gait parameters for automatic classification of neurodegenerative diseases based on these parameters.
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