Κυριακή, 23 Ιουνίου 2019

Hazardous Materials

Influence of red mud on mechanical and durability performance of self-compacting concrete

Publication date: 5 November 2019

Source: Journal of Hazardous Materials, Volume 379

Author(s): W.C. Tang, Z. Wang, S.W. Donne, M. Forghani, Y. Liu

Abstract

Red mud is a hazardous waste material produced during alkaline leaching of bauxite in the Bayer process. This study proposed the use of red mud to replace fly ash in self-compacting concrete (SCC) and the influences of red mud on fresh and hardened properties, and durability performances of SCC were studied. The fresh concrete results show that red mud had a slight negative impact on the fresh properties of SCC. The hardened concrete results show that the mechanical strength of concrete increased with increasing of red mud content. The half-cell potential test results indicated that red mud had a significant effect on restraining the corrosion process in SCC. Compared to the control sample, the red mud samples suffered less corrosion. Cracks associated with corrosion of reinforcement were observed in RMC0 and RMC100 samples after 28 day accelerated corrosion test. The ICP-MS results showed that there's no significant difference in metal elements among the solutions regardless the red mud content in concrete.The relative corrosion rate test results suggested that red mud can suppress the corrosion current. The SCC samples consisting 75% red mud performed the best resistance to corrosion according to the results of half-cell potentials and mass loss of rebar.



Butylated hydroxyanisole isomers induce distinct adipogenesis in 3T3-L1 cells

Publication date: 5 November 2019

Source: Journal of Hazardous Materials, Volume 379

Author(s): Zhendong Sun, Xiaoxi Yang, Qian S Liu, Chuanhai Li, Qunfang Zhou, Heidelore Fiedler, Chunyang Liao, Jianqing Zhang, Guibin Jiang

Abstract

Butylated hydroxyanisole (BHA) isomers, as the widely used anthropogenic antioxidants in food, have been revealed to induce endocrine disrupting effects, while the mechanism how BHA isomers regulate the lipogenic differentiation remains to be elucidated. Using 3T3-L1 differentiation model, the effects of BHA isomers, including 2-tert-butyl-4-hydroxyanisole (2-BHA), 3-tert-butyl-4-hydroxyanisole (3-BHA) and their mixture (BHA), on adipogenesis were tested. The results showed that 3-BHA and BHA promoted adipocyte differentiation and enhanced the cellular lipid accumulation through the regulation of the transcriptional and protein levels of the adipogenetic biomarkers, while 2-BHA had no effect. The effective window for 3-BHA induced lipogenesis was the first four days during 3T3-L1 differentiation. BHA isomers showed no binding affinities for peroxisome proliferator activated receptor γ (PPARγ). Instead, the upstream of PPARγ signaling pathway, i.e. the phosphorylation of cAMP-response element binding protein (CREB), upregulation of CAAT/enhancer-binding proteins β (C/EBPβ) and elevated cell proliferation during postconfluent mitosis stage were induced by 3-BHA exposure. Altogether, this study revealed the adipogenic effect of 3-BHA through interference with the upstream events of the PPARγ signaling pathway. The authorized usage of BHA as food additives and its occurrence in human sera can potentially contribute to the incidence of obesity, which is of high concern.

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Porous NiFe-oxide nanocubes derived from prussian blue analogue as efficient adsorbents for the removal of toxic metal ions and organic dyes

Publication date: 5 November 2019

Source: Journal of Hazardous Materials, Volume 379

Author(s): Yi Xie, Changlun Chen, Xirui Lu, Fen Luo, Chengming Wang, Ahmed Alsaedi, Tasawar Hayat

Abstract

A novel porous NiFe-oxide nanocubes (NiFe NCs) binary material was successfully fabricated via a facile and scalable tactic, which involved a morphology-inherited heat treating of Ni3[Fe(CN)6]2·xH2O prussian blue analogue nanocubes as self-sacrificial templates. Consequently, it was demonstrated that the NiFe NCs consisted of primary nanostructure units and interconnected pores, with an average size of ˜80 nm. When employed as adsorbents, the as-prepared NiFe NCs displayed remarkable adsorption capacities for heavy metal ions (232.3 mg g−1 for As(V) and 350.71 mg g−1 for Cr(VI)) and organic dyes (284.99 mg g−1 for XO and 31.97 mg g−1for CR at 298 K). The resulting NiFe NCs further revealed efficient regeneration and reusability even after five consecutive adsorption/desorption cycles. The microscopic spectrum analysis demonstrated that the interaction between As(V) and NiFe NCs was mainly ascribed to the metal-oxide bonds (MO) and hydroxyl groups (OH), while Cr(VI) adsorption was in conjunction with the reduction reaction of Cr(VI) to Cr(III). Furthermore, the adsorption of organic dyes on NiFe NCs depended on the pore structure and molecule sizes of the organic dye molecules. These findings make cost-efficient NiFe NCs materials a powerful candidate for remediating water contaminated with inorganic and organic contaminants.

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Experimental study on thermal structure inside flame front with a melting layer for downward flame spread of XPS foam

Publication date: 5 November 2019

Source: Journal of Hazardous Materials, Volume 379

Author(s): Shengfeng Luo, Qiyuan Xie, LiangJun Da, Rong Qiu

Abstract

Thermal structure inside flame front during downward flame spread was experimentally measured for XPS foam with thicknesses of 1.6, 2.4, 3.4, and 4.4 cm. The temperature distribution and temperature gradient in the condensed phase, as well as the shape of the molten liquid, were obtained by 2-D heat transfer equations and experimental measurement. The results show that both the temperature and its temperature gradient decrease from the sample surface to the inside of the condensed phase, which results in the inclination of the melting interface. The molten layer is the thinnest near the sample surface and thicker inside the condensed phase. The adhering of the molten liquid to the wall greatly increases the thickness of the molten layer near the back wall, and the higher the thickness, the more molten material adheres to the wall. Finally, there is a relatively flat solid-liquid interface near the sample surface and a large inclined solid-liquid interface near the back of the sample, especially for the thicker samples of 3.4cm and 4.4cm. It is indicated that the distribution of the molten layer in the direction perpendicular to the plane of the XPS sheet is a significant factor for dripping and collapsing.



Electrochemical degradation of oxalic acid over highly reactive nano-textured γ- and α-MnO2/carbon electrode fabricated by KMnO4 reduction on loofah sponge-derived active carbon

Publication date: 5 November 2019

Source: Journal of Hazardous Materials, Volume 379

Author(s): Yu-Jen Shih, Chin-Pao Huang, Ya-Han Chan, Yao-Hui Huang

Abstract

Manganese dioxide incorporated activated carbon (MnO2/AC) was synthesized and used to electrochemically degrade oxalic acid in aqueous solutions. The highly porous carbon provided reactive sites for the electro-sorption of oxalic acid and MnO2, with a specific polymorphism efficiently mediating the electron transfer between the electrode and organic pollutants. The activated carbon, made from the pyrolysis of dry loofah sponge using ZnCl2 as activating agent, exhibited a high double-layer capacitance dependent upon the heating temperature (100 F/g at 800 °C). The γ-MnO2 was in-situ deposited over the microporous structure of activated carbon through the redox reaction between KMnO4 and carbon. Simple further calcination converted γ-MnO2 to α-MnO2 nano-whisker at temperatures above 500 °C. Cyclic voltammetry showed that oxalic acid significantly improved the anodic current of the Mn(III)/Mn(IV) redox couple on the MnO2/AC electrode at an electrode potential around + 0.6 V (vs. Ag/AgCl). About 95% of oxalic acid degradation was achieved at pH < 4; meanwhile, 80% of the mineralization (total organic carbon removal) was attained independent of pH. Calcination converted γ-MnO2 to α-MnO2 which had higher electrochemical stability and inhibited the dissolution of Mn(II) from the electrode.

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Promoting Fe3+/Fe2+ cycling under visible light by synergistic interactions between P25 and small amount of Fenton reagents

Publication date: 5 November 2019

Source: Journal of Hazardous Materials, Volume 379

Author(s): Lijie Xu, Liang Meng, Xiaoxiao Zhang, Xiang Mei, Xuewen Guo, Wei Li, Ping Wang, Lu Gan

Abstract

Merits of adding P25 to homogeneous photo-Fenton-like process (ph-F) were evaluated under visible light using Bisphenol A (BPA) as a model pollutant. Interactions between P25 and Fe3+/H2O2 were emphasized. Results show that adsorption of Fe(III) on P25 produced redshift of light absorption, and interactions between P25 and H2O2 promoted photoelectron generation, effectively introducing visible light into ph-F. The visible-light-driven ph-F demonstrated adequate performance at high Fe3+/H2O2 dosage, while P25 addition showed significant acceleration of BPA degradation with saving amount of Fe3+/H2O2. The mechanism was confirmed to be enhanced Fe3+/Fe2+ cycling by photo-electrons, particularly pronounced at low [Fe(III)]. Additionally, H2O2 was utilized more efficiently in P25-ph-F than that in ph-F by diminishing the radical scavenging role of H2O2 at lower [Fe(III)]. Kinetics and ESR analysis supported this mechanism. Compared to ph-F, the P25-ph-F process also demonstrated stronger potentials in degrading BPA at high concentrations and better mineralization capability with reduced Fe3+/H2O2 reagents. The sustainability of P25-ph-F was also examined in regard to its advantage under sunlight and the strong recyclable and reusable capability. BPA decomposition was dominated by •OH attack at both the aromatic ring and the connecting carbon, and P25-ph-F was more competent in transforming the primary intermediates than ph-F.

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Influence of dissolved organic matter components on arsenate adsorption/desorption by TiO2

Publication date: 15 October 2019

Source: Journal of Hazardous Materials, Volume 378

Author(s): Meijie Ren, Guangfei Qu, Heng Li, Ping Ning

Abstract

The influences of different dissolved organic matter (DOM) components and ionic matters on As(V) adsorption/desorption behavior on the TiO2 surface were investigated. The results demonstrated that the characteristics and involving order of DOM significantly affected the As(V) adsorption/desorption behavior. The presence of DOM decreased the As(V) adsorption quantity. Fulvic acid (FA) exhibited the most negative effect, and followed by the order of alginate ≈ BSA > SDBS. The precomplexation DOM prevented more As(V) adsorption. While, the presence of DOM caused more As(V) release when the surrounding changed and FA exhibited the strongest effect. The results indicated that the site competition and electrostatic repulsion were the major mechanisms to resist As(V) adsorption. The presence of Fe3+ and Ca2+ increased As(V) adsorption by bridge effect, while PO43− and CO32− decreased As(V) adsorption owing to the competition.

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Biodegradability and ecological impacts of polyethylene-based mulching film at agricultural environment

Publication date: 15 October 2019

Source: Journal of Hazardous Materials, Volume 378

Author(s): Lijun Hou, Jiao Xi, Xiaotian Chen, Xuewen Li, Wen Ma, Jike Lu, Jing Xu, Yan Bing Lin

Abstract

Discarded Polyethylene (PE) mulches have posed a persistent pollution in the agricultural field. Although PE degraded by microbes has been reported, the effect on in situ soil environment is not completely understood. To determine the biodegradability and ecological impacts of PE-based mulches, we tested the biodegradation related properties of screened strains and analyzed change in soil quality and microbial community after covering with different mulches. Strain Bacillus aryabhattai 5-3 showed 3.85 ± 0.50% gravimetric weight loss after a 30 days incubation with PE-based mulch as the sole carbon source; Considerable pits and vast cavities were found on the surface using AFM and SEM. The hydrophobicity of mulch sheet was decreased to 68.9 ± 0.8°, FTIR identified that new oxidized groups were formed on the surfaces of incubated mulch. Additionally, the fluctuations of microbial communities indicate that synthetic mulch could replace the current commercial product to minimise agricultural pollution.

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Adsorptive removal of nitroimidazole antibiotics from water using porous carbons derived from melamine-loaded MAF-6

Publication date: 15 October 2019

Source: Journal of Hazardous Materials, Volume 378

Author(s): Mithun Sarker, Subin Shin, Sung Hwa Jhung

Abstract

Nitrogen-containing carbons were obtained via pyrolysis of melamine-loaded metal azolate frameworks (named mela@MAF-6), a sub-class of metal organic frameworks. The porosity and defect concentration of the obtained carbons (named as CDM@M-6) were dependent on the quantity of melamine loaded in the mela@MAF-6. The CDM@M-6 s were applied for the adsorptive removal of nitroimidazole antibiotics (NIABs) from water; the performance of CDM@M-6, particularly CDM(0.25)@M-6, was outstanding for the elimination of NIABs such as dimetridazole (DMZ), metronidazole (MNZ), and menidazole (MZ)) from water. The adsorption capacity of CDM(0.25)@M-6 for DMZ, MNZ, and MZ was higher than that of any adsorbent reported so far. The highest adsorptive performance of CDM(0.25)@M-6 for DMZ (Q0: 621 mg/g) and MNZ (Q0: 702 mg/g) was explained by hydrogen bonding, where CDM@M-6 and DMZ/MNZ acted as a H-donor and H-acceptor, respectively. In addition, CDM(0.25)@M-6 could be regenerated via ethanol washing and reused for next cycles without any severe decrease in performance. Therefore, CDM@M-6 is recommended as a suitable adsorbent for the elimination of NIABs from water.

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Assessment of harmfulness and biological effect of carbon fiber dust generated during new carbon fiber recycling method

Publication date: 15 October 2019

Source: Journal of Hazardous Materials, Volume 378

Author(s): Akihiro Moriyama, Takema Hasegawa, Chisato Nagaya, Kazuhiro Hamada, Takehiro Himaki, Mami Murakami, Masanori Horie, Junko Takahashi, Hitoshi Iwahashi, Hiroshi Moritomi

Abstract

Concern over the effects of nanomaterials on human health has risen due to the dramatic advances in the development of various technologies based on nanomaterials. Gifu Prefecture and Gifu University are developing technologies for recycling used carbon fiber because the waste disposal process is highly cost and energy intensive. However, generation of carbon fiber dust during the recycling process is a serious issue, especially in the occupational environment. Recycling requires carbonization by partial firing treatment at 500℃ followed by firing treatment at 440℃: these processes produce dust as a by-product. It is important to study the influence of carbon fibers on human health at a molecular level.

In this study, three types of carbon fibers - before recycling, after carbonization, and after firing were evaluated for their toxic effects on mice. During the breeding period, no loss in body weight was confirmed. Further, by staining the lung tissue sections, it was found that pulmonary fibrosis did not occur. We found that these carbon fibers might not possess severe toxicity. However, we also found that the toxicity varies according to firing treatment. Furthermore, we found that firing treatment reduces the potential hazard to human health.



Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,


Can estimated time in airway obstruction be a useful measure for infant obstructive sleep apnea?...
Can estimated time in airway obstruction be a useful measure for infant obstructive sleep apnea?Related ArticlesCan estimated time in airway obstruction be a useful measure for infant obstructive sleep apnea? Int J Pediatr Otorhinolaryngol. 2019 Jun 12;124:208-209 Authors: Daftary AS, Shively L, Slaven JE, Jalou HE PMID: 31228711 [PubMed - as supplied by publisher]International journal of pediatric otorhinolaryngology,http://goo.gl/4YdRhz19h
Αλέξανδρος Γ. Σφακιανάκης
now
Cases
Intraoperative aortic endograft placement for an unexpected plaque rupture during lung surgery.Related ArticlesIntraoperative aortic endograft placement for an unexpected plaque rupture during lung surgery. Int J Surg Case Rep. 2019 Jun 08;60:161-163 Authors: Huang W, Aramini B, Fan J Abstract BACKGROUND: Surgical resection of tumors invading the aorta is a challenging procedure. More recently, the use of thoracic aortic endografts has been reported to facilitate en bloc resection of tumors invading...
Αλέξανδρος Γ. Σφακιανάκης
1m
5,6 DICSA (dorsal inter-compartmental septal artery) or PIA(posterior interosseous artery) flap: Terminology...
5,6 DICSA (dorsal inter-compartmental septal artery) or PIA(posterior interosseous artery) flap: Terminology is important.Related Articles5,6 DICSA (dorsal inter-compartmental septal artery) or PIA(posterior interosseous artery) flap: Terminology is important. J Plast Reconstr Aesthet Surg. 2019 May 17;: Authors: Giele H PMID: 31227331 [PubMed - as supplied by publisher]Journal of plastic, reconstructive & aesthetic sur
Αλέξανδρος Γ. Σφακιανάκης
11m
Future oncology
Radiation-induced tumor immunity in patients with non-small cell lung cancer.Related ArticlesRadiation-induced tumor immunity in patients with non-small cell lung cancer. Thorac Cancer. 2019 Jun 22;: Authors: Lockney NA, Zhang M, Morris CG, Nichols RC, Okunieff P, Swarts S, Zhang Z, Zhang B, Zhang A, Hoppe BS Abstract BACKGROUND: Radiation-induced tumor immunity (RITI) influences primary tumor growth and development of metastases in preclinical cancer models with conventional radiotherapy. Antigen-specific...
Αλέξανδρος Γ. Σφακιανάκης
11m
Sleep apnea
Can estimated time in airway obstruction be a useful measure for infant obstructive sleep apnea?Related ArticlesCan estimated time in airway obstruction be a useful measure for infant obstructive sleep apnea? Int J Pediatr Otorhinolaryngol. 2019 Jun 12;124:208-209 Authors: Daftary AS, Shively L, Slaven JE, Jalou HE PMID: 31228711 [PubMed - as supplied by publisher]pubmed: sleep apnea19hImpact of obstructive sleep apnea on optic nerve function in patients with craniosynostosis and recurrent intracranial...
Αλέξανδρος Γ. Σφακιανάκης
12m
Leak of cerebrospinal fluid
Intradural non-calcified thoracic disc herniation causing spontaneous intracranial hypotension: a case report.Related ArticlesIntradural non-calcified thoracic disc herniation causing spontaneous intracranial hypotension: a case report. BMC Surg. 2019 Jun 21;19(1):66 Authors: Fiechter M, Ott A, Beck J, Weyerbrock A, Fournier JY Abstract BACKGROUND: Spontaneous intracranial hypotension (SIH) is a rare pathology caused by a cerebrospinal fluid (CSF) leak. If intractable by conventional methods (i.e....
Αλέξανδρος Γ. Σφακιανάκης
13m
Upper respiratory tract infection
Detection of influenza D virus in bovine respiratory disease samples, U.K.Related ArticlesDetection of influenza D virus in bovine respiratory disease samples, U.K. Transbound Emerg Dis. 2019 Jun 22;: Authors: Dane H, Duffy C, Guelbenzu M, Hause B, Fee S, Forster F, McMenamy MJ, Lemon K Abstract Influenza D is a newly described virus of cattle, pigs and small ruminants first detected in North America during 2011. Cattle have been shown to be the main viral reservoir and mounting evidence indicates...
Αλέξανδρος Γ. Σφακιανάκης
13m
Biophysics
Study of the mechanical properties of fresh and cryopreserved individual human oocytesAbstract In assisted reproduction technologies, the cryopreservation of oocytes is a common procedure used to circumvent female infertility. However, some morphological and functional alterations of oocytes have been observed depending on the protocol applied. In this work, the mechanical response of individual human oocytes before and after a freeze-thawing procedure was characterised. Oocytes, immediately after...
Αλέξανδρος Γ. Σφακιανάκης
14m
Psychopharmacology
A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophreniaAbstract Rationale Schizophrenia and stimulant-induced psychosis (SIP) represent two different forms of psychotic disorder, with different etiologies. While many of the symptoms of psychosis are common to both disorders, there have been few direct comparisons between these conditions, especially when controlling for stimulant use in individuals with schizophrenia....
Αλέξανδρος Γ. Σφακιανάκης
15m
Maternal and Child Health
Dietary Energy–Density and Adiposity Markers Among a Cohort of Multi-ethnic ChildrenAbstract Background Evidence suggests that the association between dietary energy density (DED) and body composition in children is different than in adults. The purpose of this study was to measure if DED differed by race/ethnicity and if DED was associated with adiposity markers in children. Methodology Dietary intake and body composition were measured...Latest Results for Maternal and Child Health Journal1dEffects...
Αλέξανδρος Γ. Σφακιανάκης
16m
Orthodontic Society
New open access no-fee journal on rural neurosciencesJournal of Neurosciences in Rural Practice (www.ruralneuropractice.com) is new semi-annual peer-reviewed open access journal to be published from January 2010 on behalf of the Associacion Ayuda Enfermo Neuroquirurgico. The journal would not charge the authors for submission, processing or publication of manuscripts and would provide immediate free access to all its content.September-2009Journal of Indian Orthodontic Society : 2018 - 52(2)20hNonsurgical,...
Αλέξανδρος Γ. Σφακιανάκης
17m
Dermatologic Therapy
Rosai‐Dorfman disease successfully treated with thalidomide: a case reportAbstract Rosai‐Dorfman disease (RDD) is a rare disease which characterized by proliferation and overproduction of histiocytes in the lymph nodes appearing as lymphadenopathy, however, it may also occur in extranodal sites. The occurrence of unusual manifestations of the disease such as the appearance of the mass in an unusual area may increase the probability of misdiagnosis. Herein, we describe a case of RDD in an old woman...
Αλέξανδρος Γ. Σφακιανάκης
18m
Interaction of photoprotective and acclimation mechanisms in Ulva rigida (Chlorophyta) in response...
Interaction of photoprotective and acclimation mechanisms in Ulva rigida (Chlorophyta) in response to diurnal changes in solar radiation in southern Chile.Related ArticlesInteraction of photoprotective and acclimation mechanisms in Ulva rigida (Chlorophyta) in response to diurnal changes in solar radiation in southern Chile. J Phycol. 2019 Jun 21;: Authors: Cruces E, Rautenberger R, Cubillos VM, Ramírez-Kushel E, Rojas-Lillo Y, Lara C, Montory JA, Gómez I Abstract Species of the genus Ulva (Chlorophyta)...
Αλέξανδρος Γ. Σφακιανάκης
18m
The Protective Effects of a Combination of an Arginine Silicate Complex and Magnesium Biotinate Against...
The Protective Effects of a Combination of an Arginine Silicate Complex and Magnesium Biotinate Against UV-Induced Skin Damage in Rats (P06-028-19).Related ArticlesThe Protective Effects of a Combination of an Arginine Silicate Complex and Magnesium Biotinate Against UV-Induced Skin Damage in Rats (P06-028-19). Curr Dev Nutr. 2019 Jun;3(Suppl 1): Authors: Komorowski J, Ojalvo SP, Sylla S, Cicek D, Demir B, Orhan C, Tuzcu M, Sahin N, Sahin K Abstract Objectives: Skin appearance and function begin...
Αλέξανδρος Γ. Σφακιανάκης
19m
Technologies in Treatment of Head & Neck
Peripheral Focused Ultrasound Stimulation (pFUS): New Competitor in Pharmaceutical Markets?Related ArticlesPeripheral Focused Ultrasound Stimulation (pFUS): New Competitor in Pharmaceutical Markets? SLAS Technol. 2019 Jun 17;:2472630319849383 Authors: Cotero V, Graf J, Zachs DP, Tracey KJ, Ashe J, Lim HH, Puleo C Abstract A new study published in Nature Communications outlines our group's results using focused ultrasound stimulation within peripheral organs to precisely activate autonomic nerve circuits....
Αλέξανδρος Γ. Σφακιανάκης
19m
Evolutionary Biology
Maternal stress promotes offspring growth without oxidative costs in wild red squirrels [NEW RESULTS]Elevations in glucocorticoid levels (GCs) in breeding females (often called maternal stress) may induce adaptive shifts in offspring life histories. Offspring produced by mothers with elevated GCs may be better prepared to face harsh environments where a faster pace of life is beneficial. We examined how experimentally elevated GCs in pregnant or lactating North American red squirrels (Tamiasciurus...
Αλέξανδρος Γ. Σφακιανάκης
20m
Accurate GFR in obesity—protocol for a systematic review Obesity is increasing globally. Chronic...
Accurate GFR in obesity—protocol for a systematic reviewObesity is increasing globally. Chronic kidney disease (CKD) is strongly associated with obesity. Kidney function is commonly estimated with equations using creatinine (such as CKD-EPI equation) which is a pro...Systematic Reviews - Latest Articles1dPalliative care interventions in intensive care unit patients – a systematic review protocolEven though data suggest that palliative care (PC) improves patient quality of life, caregiver burden,...
Αλέξανδρος Γ. Σφακιανάκης
20m
From sheep and cattle to giraffes, genome study reveals evolution of ruminants A detailed study...
From sheep and cattle to giraffes, genome study reveals evolution of ruminantsA detailed study of the genomes of 44 species of ruminants gives new insight into the evolution and success of these mammals.Evolutionary Biology News -- ScienceDaily1d
Αλέξανδρος Γ. Σφακιανάκης
21m
Morphology of the Homo naledi femora from Lesedi Abstract Objectives The femoral remains recovered...
Morphology of the Homo naledi femora from LesediAbstract Objectives The femoral remains recovered from the Lesedi Chamber are among the most complete South African fossil hominin femora discovered to date and offer new and valuable insights into the anatomy and variation of the bone in Homo naledi. While the femur is one of the best represented postcranial elements in the H. naledi assemblage from the Dinaledi Chamber, the fragmentary and commingled nature of the Dinaledi femoral remains has impeded...
Αλέξανδρος Γ. Σφακιανάκης
21m
Medicine
A multicenter, prospective phase II trial of gemcitabine plus axitinib in patients with renal cell carcinoma with a predominant sarcomatoid componentSummary Introduction We conducted a multicenter, phase 2 trial using gemcitabine plus axitinib (GX) in patients with recurrent or metastatic sarcomatoid renal cell carcinoma (SRCC) to evaluate its efficacy and safety. Methods Patients with advanced RCC and a sarcomatoid component of ≥25% on resected kidney or exclusive sarcomatoid carcinoma on needle...
Αλέξανδρος Γ. Σφακιανάκης
26m
Endocrinology
Vitamin D, cancer, and dysregulated phosphate metabolismAbstract Recently reported findings from major clinical trials show no cancer protection from vitamin D supplementation, and results from observational studies of vitamin D in cancer prevention are inconsistent. There is a need for new hypotheses to guide investigations of the controversies surrounding vitamin D supplementation and cancer. Bioactive vitamin D, 1,25(OH)2D, is an endocrine factor that regulates phosphate homeostasis by increasing...
Αλέξανδρος Γ. Σφακιανάκης
29m
Head and Neck
Measurement of the depth of facial nerve at the level of stylomastoid foramen using MR imaging in Bell's palsy.Related ArticlesMeasurement of the depth of facial nerve at the level of stylomastoid foramen using MR imaging in Bell's palsy. Clin Imaging. 2019 Jun 14;58:34-38 Authors: Karaca H, Soydan L, Yildiz S, Toros SZ Abstract OBJECTIVES: To investigate whether the depth of the facial nerve from the skin surface as it exits the stylomastoid foramen differs between the paralyzed and unaffected sides...
Αλέξανδρος Γ. Σφακιανάκης
30m
Therapy
A multicenter, prospective phase II trial of gemcitabine plus axitinib in patients with renal cell carcinoma with a predominant sarcomatoid componentSummary Introduction We conducted a multicenter, phase 2 trial using gemcitabine plus axitinib (GX) in patients with recurrent or metastatic sarcomatoid renal cell carcinoma (SRCC) to evaluate its efficacy and safety. Methods Patients with advanced RCC and a sarcomatoid component of ≥25% on resected kidney or exclusive sarcomatoid carcinoma on needle...
Αλέξανδρος Γ. Σφακιανάκης
33m
Ca
The role of mouse tumour models in the discovery and development of anticancer drugsBritish Journal of Cancer, Published online: 24 June 2019; doi:10.1038/s41416-019-0495-5The role of mouse tumour models in the discovery and development of anticancer drugsCancer4hObesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East AsiansBritish Journal of Cancer, Published online: 24 June 2019; doi:10.1038/s41416-019-0500-zObesity, abdominal obesity and subsequent...
Αλέξανδρος Γ. Σφακιανάκης
33m
Hearing Balance
Livio AI: Evolution of the Hearing RevolutionWith the introduction of Livio AI Healthable Hearing Technology, Starkey began the process of redefining the hearing aid. This continues with the next evolution of Livio AI, the Thrive Hearing Control Mobile App and the Starkey Hearing Technologies 2.4 GHz patient-focused accessories. This session will provide an overview of the latest Starkey Healthable Hearing Technology, hearing aids, accessories and features.Audiology1hTrends in Bone Conduction: Considerations...
Αλέξανδρος Γ. Σφακιανάκης
35m
Allergy, Asthma ,Immunology
Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activityAbstract Background Over 100 million people worldwide suffer from birch pollen allergy. Bet v 1 has been identified as the major birch pollen allergen. However, the molecular mechanisms of birch allergic sensitization, including the roles of Bet v 1 and other components of the birch pollen extract, remain incompletely understood. Here, we examined how known birch pollen‐derived molecules influence...
Αλέξανδρος Γ. Σφακιανάκης
37m
Craniofacial
Audit of the rates of re-excision for close or involved margins in the management of oral cancerPublication date: Available online 22 June 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): S. Azzopardi, D. Lowe, S. RogersAbstractThe need for re-excision of close or involved margins after the resection of oral cancer is debatable. This audit comprised 640 consecutive patients over an 11-year period with at least five years' follow up. A total of 213 patients (33%) had resection...
Αλέξανδρος Γ. Σφακιανάκης
38m
Pathology
The utility of longitudinal slicing method for rectal specimen: pathological analysis of circumferential resection margin of intersphincteric resection for low‐lying rectal cancerAbstract The pathological assessment of the resection margin of rectal cancer is important to predict clinical outcome. The transverse slicing method of rectal specimens is recommended in Western countries. However, in Japan the longitudinal slicing method is traditionally advocated. The aim of this study was to assess the...
Αλέξανδρος Γ. Σφακιανάκης
39m
Dysphagia
Hypopharyngeal Diverticulum: Toward a Unified Understanding of Its EtiopathogenesisAbstract The etiopathogenesis of Zenker's diverticulum (ZD) remains uncertain. Increased hypopharyngeal pressure due to a hypertonic upper esophageal sphincter results in herniation proximal to the sphincter producing a pulsion diverticulum. Gastroesophageal reflux, which is known to induce shortening of the injured esophagus, likely plays a prominent role in ZD formation by pulling the cricopharyngeus muscle (CPM)...
Αλέξανδρος Γ. Σφακιανάκης
40m
Oral and Maxillofacial
Long-term outcomes 1–20 years after autotransplantation of teeth: clinical and radiographic evaluation of 66 premolars and 8 molarsIn this retrospective study we investigated the long-term survival of autotransplanted premolars and molars with incompletely developed roots. The presence of the transplanted teeth and their outcome after autotransplantation was ascertained from clinical and radiographic evaluation by a maxillofacial surgeon or dentist. Kaplan Meier survival curves were estimated for...
Αλέξανδρος Γ. Σφακιανάκης
42m
Neurology
Nusinersen in type 1 Spinal Muscular Atrophy: 12‐month real world dataABSTRACT Objective The aim of the study was to report 12‐month changes after treatment with Nusinersen in a cohort of 85 type I Spinal Muscular Atrophy patients of age ranging from 2 months to 15 years and 11 months. Methods All patients were assessed using the Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND) and the Hammersmith Infant Neurological Examination‐Section 2 (HINE‐2). Results...
Αλέξανδρος Γ. Σφακιανάκης
44m
Language
Efficacy of Voice Therapy in Improving Vocal Function in Adults Irradiated for Laryngeal Cancers: A Pilot StudyRadiation therapy (XRT) for laryngeal cancers causes acute and chronic vocal dysfunction. Although these deleterious effects of XRT are well-established, there is a dearth of research with respect to effective voice rehabilitation following XRT for laryngeal cancers.Journal of Voice1dEfficacy of Voice Therapy in Improving Vocal Function in Adults Irradiated for Laryngeal Cancers: A Pilot...
Αλέξανδρος Γ. Σφακιανάκης
45m
ENT
The Management of Suspected or Confirmed Laryngopharyngeal Reflux Patients with recalcitrant Symptoms: A Contemporary ReviewAbstract Objective To summarize current knowledge about the prevalence, etiology and management of recalcitrant laryngopharyngeal reflux (LPR) patients ‐ those who do not respond to anti‐reflux medical treatment. Methods A literature search was conducted following the PRISMA guidelines to identify studies that reported success of anti‐reflux medical treatment with emphasis on...
Αλέξανδρος Γ. Σφακιανάκης
46m
Procalcitonin, C-Reactive Protein, Albumin, and Blood Cultures as Early Markers of Sepsis Diagnosis...
Procalcitonin, C-Reactive Protein, Albumin, and Blood Cultures as Early Markers of Sepsis Diagnosis or Predictors of Outcome: A Prospective AnalysisShow lessAna Cristina Schmidt de Oliveira-Netto, Luis G Morello, Libera M Dalla-Costa, Ricardo R Petterle, Rafael M Fontana, Danieli Conte, Luciane A Pereira, Sonia M RaboniFirst Published June 18, 2019 Research Article https://doi.org/10.1177/2632010X19847673Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseArticle...
Αλέξανδρος Γ. Σφακιανάκης
49m
Molecular detection of fungal and bacterial DNA from pustules in patients with palmoplantar pustulosis:...
Molecular detection of fungal and bacterial DNA from pustules in patients with palmoplantar pustulosis: special focus on Malassezia speciesY. Matsumoto  K. Harada  T. Maeda  C. Egusa  H. Hirano  Y. Okubo  R. TsuboiFirst published: 20 June 2019 https://doi.org/10.1111/ced.14026This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and...
Αλέξανδρος Γ. Σφακιανάκης
51m
Potential of reagent strips to aid detection of bacterial infection from exudates of skin lesions: a...
Potential of reagent strips to aid detection of bacterial infection from exudates of skin lesions: a pilot studyS. Tso  T.N. ShimFirst published: 19 June 2019 https://doi.org/10.1111/ced.14025This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/ced.14025ePDFPDFTOOLS...
Αλέξανδρος Γ. Σφακιανάκης
51m
Male genital lichen sclerosus and filaggrin T.N. Shim  S. Brown  N.D. Francis  M. Dinneen  D. Hawkins ...
Male genital lichen sclerosus and filaggrinT.N. Shim  S. Brown  N.D. Francis  M. Dinneen  D. Hawkins  A. Muneer  S. Minhas  I. McLean  C.B. BunkerFirst published: 17 June 2019 https://doi.org/10.1111/ced.14023This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/ced.14023ePDFPDFTOOLS...
Αλέξανδρος Γ. Σφακιανάκης
52m
Gut dysbiosis: not only with checkpoint inhibitors! M. Piroth  C. Frenard  G. Quereux  A. Khammari ...
Gut dysbiosis: not only with checkpoint inhibitors!M. Piroth  C. Frenard  G. Quereux  A. Khammari  S. Corvec  B. DrénoFirst published: 21 June 2019 https://doi.org/10.1111/ced.14018
Αλέξανδρος Γ. Σφακιανάκης
52m
An observational analysis of low‐dose thalidomide in recalcitrant prurigo nodularis K. Sardana  A. Gupta ...
An observational analysis of low‐dose thalidomide in recalcitrant prurigo nodularisK. Sardana  A. Gupta  S. SinhaFirst published: 27 May 2019 https://doi.org/10.1111/ced.14015Conflict of interest: the authors declare that they have no conflicts of interest.Read the full textePDFPDFTOOLS SHARESummaryThalidomide has been used as an effective treatment for prurigo nodularis (PN) with a median dose of 200 mg, but the risk of peripheral neuropathy precludes long‐term use. We analysed the efficacy of low‐dose...
Αλέξανδρος Γ. Σφακιανάκης
52m

Viral‐associated trichodysplasia spinulosa in a paediatric cardiac transplant recipient C. Stephan ...
Viral‐associated trichodysplasia spinulosa in a paediatric cardiac transplant recipientC. Stephan  M. Kurban  S. Khalil  F. Bitar  I. El‐Rassi  J. AssyFirst published: 20 June 2019 https://doi.org/10.1111/ced.14017
Αλέξανδρος Γ. Σφακιανάκης
53m
Total body skin examination increases squamous cell carcinoma detection: a retrospective cohort study...
Total body skin examination increases squamous cell carcinoma detection: a retrospective cohort studyZ. Ali  P. M. ToddFirst published: 23 May 2019 https://doi.org/10.1111/ced.14013Conflict of interest: the authors declare that they have no conflicts of interest.Read the full textePDFPDFTOOLS SHARESummarySquamous cell carcinomas (SCCs) have the potential for local tissue destruction and metastasis. The risk of complications increases if the lesion is not diagnosed and excised in a timely manner....
Αλέξανδρος Γ. Σφακιανάκης
53m
Digestive Diseases and Sciences
Correction to: Fecal Microbiota Transplantation Capsules with Targeted Colonic Versus Gastric Delivery in Recurrent Clostridium difficile Infection: A Comparative Cohort Analysis of High and Low DoseThe original version of the article unfortunately contained an error in article title. The corrected title is 'Fecal Microbiota Transplantation Capsules with Targeted Colonic Versus Gastric Delivery in Recurrent Clostridium difficileInfection: A Comparative Cohort Analysis of High and Low Dose'.Third...
Αλέξανδρος Γ. Σφακιανάκης
55m
Twenty-three years follow-up after low-dose Gamma Knife surgery of a brainstem juvenile pilocytic astrocytoma:...
Twenty-three years follow-up after low-dose Gamma Knife surgery of a brainstem juvenile pilocytic astrocytoma: a case report and review of the literatureAbstractJuvenile pilocytic astrocytoma (JPA) is a World Health Organization (WHO) grade I tumor that is the commonest to occur in the 0–19 age group, with an excellent prognosis of 96% 10-year survival in pediatric patients. Complete resection is the treatment of choice for JPAs. However, this is not always feasible due to the location of certain...
Αλέξανδρος Γ. Σφακιανάκης
56m
Topical instillation of vancomycin lowers the rate of CSF shunt infections in children AbstractIntroduction...
Topical instillation of vancomycin lowers the rate of CSF shunt infections in childrenAbstractIntroductionShunt surgery in pediatric patients still bears a significant risk of infection, in addition to mechanical complications of the shunt system. Antibiotic-impregnated systems and perioperative antibiotics have been extensively studied for their potential to reduce shunt infections. We examined the effectiveness of intrawound application of vancomycin powder during shunt surgery.Patients and methodsPatient...
Αλέξανδρος Γ. Σφακιανάκης
57m
Enhancing nodular lesions in Chiari II malformations in the setting of persistent hindbrain herniation:...
Enhancing nodular lesions in Chiari II malformations in the setting of persistent hindbrain herniation: case report and literature reviewAbstractBackgroundChiari II malformation includes concomitant cerebellar tonsillar herniation, hydrocephalus, and myelomeningocele. Rarely, pediatric patients with persistent hindbrain herniation develop a new enhancing nodule at the cervicomedullary junction as adults. These new lesions may be suspicious for neoplastic growth, but it remains unclear if neurosurgical...
Αλέξανδρος Γ. Σφακιανάκης
57m
A case of central nervous system vasculitis presenting as a mass-like lesion Abstract Vasculitis of...
A case of central nervous system vasculitis presenting as a mass-like lesionAbstractVasculitis of the central nervous system presenting as a mass lesion is a relatively uncommon occurrence. Even more uncommon is a vasculitis mimicking a demyelinating lesion. We present here an interesting case of a 15-year-old boy who was found to have a mass-like lesion on neuroimaging involving the left subcortical white matter and deep gray matter. The differential diagnosis for this lesion was primary demyelination...
Αλέξανδρος Γ. Σφακιανάκης
57m
A child with a stroke, drug-refractory epilepsy and congenital heart disease: can a hemispherectomy...
A child with a stroke, drug-refractory epilepsy and congenital heart disease: can a hemispherectomy be safely performed between staged cardiac procedures?AbstractBackgroundThe safety of hemispherectomy between staged cardiac procedures is unknown and not previously reported.MethodRetrospective review of a case with drug-resistant epilepsy due to stroke following bidirectional cavopulmonary connection (BDCPC).ResultsThis report describes the first case of a successful pediatric peri-insular functional...
Αλέξανδρος Γ. Σφακιανάκης
57m
Child's Nervous System
Pseudo-spontaneous third ventriculostomyTwenty-three years follow-up after low-dose Gamma Knife surgery of a brainstem juvenile pilocytic astrocytoma: a case report and review of the literatureAbstractJuvenile pilocytic astrocytoma (JPA) is a World Health Organization (WHO) grade I tumor that is the commonest to occur in the 0–19 age group, with an excellent prognosis of 96% 10-year survival in pediatric patients. Complete resection is the treatment of choice for JPAs. However, this is not always...
Αλέξανδρος Γ. Σφακιανάκης
58m
Microvascular decompression with partial occipital condylectomy in a case of pediatric spasmodic torticollis...
Microvascular decompression with partial occipital condylectomy in a case of pediatric spasmodic torticollisAbstractSpasmodic torticollis is a rare, neurologic disorder that is caused by abnormal nerve compression of the 11th cranial nerve by blood vessels or bony protrusions. It is typically treated pharmacologically and, if necessary, with surgical intervention. We report a unique case of spasmodic torticollis in a 15-year-old female that involved abnormal compression of the left 11th cranial nerve...
Αλέξανδρος Γ. Σφακιανάκης
58m
Needs and Solutions
I Paid More than You (Before)?! The Effects of Self-Construal and Comparison Target on Price Unfairness PerceptionsAbstractPrevious research suggests that when consumers encounter discrepant prices due to dynamic pricing, a social comparison evokes stronger unfairness perceptions than a temporal comparison does. In this paper, the authors show how this effect may vary depending on consumers' self-construal. Two experiments find that while independent consumers perceive stronger price unfairness when...
Αλέξανδρος Γ. Σφακιανάκης
59m
Ethics
Erratum to: Abusive Supervision and Subordinate Proactive Behavior: Joint Moderating Roles of Organizational Identification and Positive AffectivityThe original version of this article was corrected: Figures 5 and 6 were updated.Normative Underpinnings of Direct Employee Participation Studies and Implications for Developing Ethical Reflexivity: A Multidisciplinary ReviewAbstractThis paper seeks to join studies which have drawn attention to the ethical reflexivity of research and the research enterprise...
Αλέξανδρος Γ. Σφακιανάκης
1h
Synthese
Artifacts and affordancesAbstractWhat are the affordances of artifacts? One view is that the affordances of artifacts, just as the affordances of natural objects, pertain to possible ways in which they can be manipulated (e.g., a computer keyboard affords grasping). Another view maintains that, given that artifacts are sociocultural objects, their affordances pertain primarily to their culturally-derived function (e.g., a computer keyboard affords typing). Whereas some have tried to provide a unifying...
Αλέξανδρος Γ. Σφακιανάκης
1h
Clinical Pharmacokinetics
Authors' Reply to Nicolas: "Levothyrox ® New and Old Formulations: Are they Switchable for Millions of Patients?"Authors' Reply to Castello-Bridoux et al.: "Comment on Levothyrox ® New and Old Formulations: Are they Switchable for Millions of Patients?"Comment on: "Levothyrox ® New and Old Formulations: Are they Switchable for Millions of Patients?"Comment on: Levothyrox ® New and Old Formulations: Are They Switchable for Millions of Patients?Comment on "Target-Controlled Continuous Infusion for...
Αλέξανδρος Γ. Σφακιανάκης
1h
Physiologically Based Pharmacokinetic Modeling for Trimethoprim and Sulfamethoxazole in Children AbstractObjective...
Physiologically Based Pharmacokinetic Modeling for Trimethoprim and Sulfamethoxazole in ChildrenAbstractObjectiveThe aims of this study were to (1) determine whether opportunistically collected data can be used to develop physiologically based pharmacokinetic (PBPK) models in pediatric patients; and (2) characterize age-related maturational changes in drug disposition for the renally eliminated and hepatically metabolized antibiotic trimethoprim (TMP)–sulfamethoxazole (SMX).MethodsWe developed separate...
Αλέξανδρος Γ. Σφακιανάκης
1h
Environmental
Review of The story of White Hall Centre: Outdoor education across the decades by Pete McDonaldReview of Ontology and closeness in human-nature relationships: Beyond dualisms, materialism and posthumanism by Neil H. KesslerTeacher and student perceptions of an outdoor classroomAbstractA six-week study was conducted with two kindergarten teachers and 37 kindergarten students aged five and six to determine their perceptions of teaching and learning in a traditional indoor classroom compared to a newly...
Αλέξανδρος Γ. Σφακιανάκης
1h
Association between atrial fibrillation and Helicobacter pylori Abstract The connection between atrial...
Association between atrial fibrillation and Helicobacter pyloriAbstractThe connection between atrial fibrillation (AF) and H. pylori (HP) infection is still matter of debate. We performed a systematic review and metanalysis of studies reporting the association between AF and HF. A systematic review of all available reports in literature of the incidence of HP infection in AF and comparing this incidence with subjects without AF were analysed. Risk ratio and 95% confidence interval (CI) and risk difference...
Αλέξανδρος Γ. Σφακιανάκης
1h
Cardiology
Retrieval of an embolised occluder with an alligator forceps during staged paravalvular leakage closurePercutaneous closure of a large atrial septal defect presenting with acute severe hemolysisAssociation between atrial fibrillation and Helicobacter pyloriAbstractThe connection between atrial fibrillation (AF) and H. pylori (HP) infection is still matter of debate. We performed a systematic review and metanalysis of studies reporting the association between AF and HF. A systematic review of all...
Αλέξανδρος Γ. Σφακιανάκης
1h
Child & Adolescent Trauma
Mentalization-Based Training Program for Child Care Workers in Residential SettingsAbstractMost of the children placed in child welfare residential care have experienced complex traumas linked to various forms of abuse and neglect, which have many important developmental impacts. Research shows that maltreatment is associated with increased aggression and disruptive behavior, internalizing difficulties, violence towards self and others, sexualized behaviors, academic difficulties, and early drug...
Αλέξανδρος Γ. Σφακιανάκης
1h
Criminology
Mandatory, fast, and fair: Case outcomes and procedural justice in a family drug courtAbstractObjectivesProblem-solving courts are traditionally voluntary in nature to promote procedural justice and to advance therapeutic jurisprudence. The Family Treatment Drug Court (FTDC) in Lancaster County, Nebraska is a mandatory dependency court for families with allegations of child abuse or neglect related to substance use. We conducted a program evaluation examining parents' case outcomes and perceptions...
Αλέξανδρος Γ. Σφακιανάκης
1h

Skeletal Radiology
Test Yourself: Question: "Painless right leg swelling"Browser's notesSkeletal Radiology: The Year in Review 2018Selective rickets from localized advanced maturation—a case reportAbstractAn unusual cause of rickets is illustrated by a patient with infantile multisystem inflammatory disease who, by age 2 years and 4 months, developed striking radiographic and clinical rickets restricted to those joints involved by the inflammatory process. The locally increased vascularity from his inflammation led...
Αλέξανδρος Γ. Σφακιανάκης
1h
Brain
Is schizotypic maternal personality linked to sensory gating abilities during infancy?AbstractSchizotypy is a personality dimension within the general population elevated among schizophrenia-spectrum patients and their first-degree relatives. Sensory gating is the pre-attentional habituation of responses distinguishing between important and irrelevant information. This is measured by event-related potentials, which have been found to display abnormalities in schizophrenic disorders. The current study...
Αλέξανδρος Γ. Σφακιανάκης
1h
Porocarcinoma of the nail: A dermoscopic observation Michał Sobjanek  Martyna Sławińska  Kamil Drucis ...
Porocarcinoma of the nail: A dermoscopic observationMichał Sobjanek  Martyna Sławińska  Kamil Drucis  Roman J. Nowicki  Wojciech BiernatFirst published: 18 June 2019 https://doi.org/10.1111/ajd.13094
Αλέξανδρος Γ. Σφακιανάκης
1h
A case of Pemphigus Vulgaris associated with cocaine snorting Mariachiara Arisi  Alessandra Gelmetti ...
A case of Pemphigus Vulgaris associated with cocaine snortingMariachiara Arisi  Alessandra Gelmetti  Marta Fusano  Luisa Lorenzi  Giulia Petrilli  Giorgio Pasolini Annalisa Vascellaro  Marina Venturini  Piergiacomo Calzavara‐PintonFirst published: 18 June 2019 https://doi.org/10.1111/ajd.13092
Αλέξανδρος Γ. Σφακιανάκης
1h
Dipeptidyl peptidase‐4 inhibitors and bullous pemphigoid: A systematic review and adjusted meta‐analysis...
Dipeptidyl peptidase‐4 inhibitors and bullous pemphigoid: A systematic review and adjusted meta‐analysisKevin Phan  Olivia Charlton  Saxon D SmithFirst published: 19 June 2019 https://doi.org/10.1111/ajd.13100Kevin Phan, MD. Olivia Charlton, MD. Saxon D Smith, MBBS, FACD.Funding sources: None.Conflicts of interest: All authors do not have conflicts of interest relevant to this study.Read the full textePDFPDFTOOLS SHAREAbstractBackground/ObjectiveThere have been a number of case reports and small...
Αλέξανδρος Γ. Σφακιανάκης
1h
Tissue inflammatory biomarkers in chronic plaque psoriasis: Exploring lesional versus non‐lesional skin...
Tissue inflammatory biomarkers in chronic plaque psoriasis: Exploring lesional versus non‐lesional skin relative expression and possible clinical correlationsAlvaro Martínez‐Doménech  Pablo Hernández‐Bel  Marta García‐Legaz Martínez  Jorge Magdaleno‐Tapial  Cristian Valenzuela‐Oñate  Manuel Mata‐Roig  Jose‐Luis Sánchez‐Carazo … See all authorsFirst published: 19 June 2019 https://doi.org/10.1111/ajd.13104
Αλέξανδρος Γ. Σφακιανάκης
1h
Nuclear Medicine and Molecular Imaging
Endorsement of International Consensus Radiochemistry Nomenclature GuidelinesTreatment of brain metastases of castration-resistant prostate cancer with 225 Ac-PSMA-617Retroperitoneal fibrosis in on-going anti-PD-1 immunotherapy detected with [ 18 F]-FDG PET/CTCorrection to: 18 F-DOPA PET/CT in brain tumors: impact on multidisciplinary brain tumor board decisionsJérôme Barriere was inadvertently missing in the original version of this article. He has participated to the study design, protocol writing...
Αλέξανδρος Γ. Σφακιανάκης
1h
Child and Adolescent Social Work
Prevalence of Substance Use, Housing Instability, and Self-Perceived Preparation for Independence Among Current and Former Foster YouthAbstractThis study assesses prevalence of substance use, and the impact of housing instability. and independence preparation on substance use in two samples: youth currently in-care and former foster youth. Both samples were from a mid-Atlantic state with youth currently in-care residing in rural jurisdictions and former foster youth residing in the state's largest...
Αλέξανδρος Γ. Σφακιανάκης
1h
Critical Care Medicine
Perioperative Assessment of Cerebral Oxygen Metabolism in Infants With Functionally Univentricular Hearts Undergoing the Bidirectional Cavopulmonary ConnectionObjectives: The transition from single-ventricle lesions with surgically placed systemic-to-pulmonary artery shunt to the circulation following a bidirectional cavopulmonary connection results in higher pressure in the superior vena cava when compared with the preceding circulation. The aim of this study was to evaluate the impact of this transition...
Αλέξανδρος Γ. Σφακιανάκης
21h
Acta Neurochirurgica
JEDI (jugular entrapment, dilated ventricles, intracranial hypertension) syndrome: a new clinical entity? A case reportAbstractPatients with idiopathic intracranial hypertension are frequently obese women with normal/slit ventricles. Patients with high-pressure hydrocephalus, instead, present enlarged ventricles. We describe a 63-year-old woman with signs and symptoms of intracranial hypertension. Brain MRI revealed hydrocephalus. Venous Doppler ultrasound showed external compression of the omohyoid...
Αλέξανδρος Γ. Σφακιανάκης
1d
Applied Biochemistry and Biotechnology
Author Correction: Drier Climatic Conditions Increase Withanolide Content of Withania coagulans Enhancing its Inhibitory Potential against Human Prostate Cancer CellsThe original version of this article unfortunately contained a mistake in the image of Figure 1 and in Table 4. The corrected version of the figure and table is shown here.Application of Acid and Cold Stresses to Enhance the Production of Clavulanic Acid by Streptomyces clavuligerusAbstractClavulanic acid (CA) is frequently prescribed...
Αλέξανδρος Γ. Σφακιανάκης
1d
Mind & Society
Brexit behaviourally: lessons learned from the 2016 referendumAbstractNobel Prize winner Richard Thaler was among those who expected Remain to win the EU referendum. Yet on 23 June 2016, a majority in the UK voted to Leave by a margin of 52–48%. A study of over 450 Leave voters, based on the MINDSPACE framework, looks at whether behavioural factors affected the outcome and at what lessons could be learned for any future votes. It finds that voters had low levels of knowledge which may have undermined...
Αλέξανδρος Γ. Σφακιανάκης
1d
Molecular Medicine
Correction to: Critical role of interleukin-23 in development of asthma promoted by cigarette smokeThe original publication of this paper contains a mistake.Pathological cardiac hypertrophy: the synergy of adenylyl cyclases inhibition in cardiac and immune cells during chronic catecholamine stressAbstractResponse to stressors in our environment and daily lives is an adaptation conserved through evolution as it is beneficial in enhancing the survival and continuity of humans. Although stressors have...
Αλέξανδρος Γ. Σφακιανάκης
1d
Clinical Neuroradiology
Performance of a Deep-Learning Neural Network to Detect Intracranial Aneurysms from 3D TOF-MRA Compared to Human ReadersAbstractPurposeTo study the clinical potential of a deep learning neural network (convolutional neural networks [CNN]) as a supportive tool for detection of intracranial aneurysms from 3D time-of-flight magnetic resonance angiography (TOF-MRA) by comparing the diagnostic performance to that of human readers.MethodsIn this retrospective study a pipeline for detection of intracranial...
Αλέξανδρος Γ. Σφακιανάκης
1d
Clinical Pharmacology
Balancing medication use in nursing home residents with life-limiting diseaseAbstractPurposeBalancing medications that are needed and beneficial and avoiding medications that may be harmful is important to prevent drug-related problems, and improve quality of life. The aim of this study is to describe medication use, the prevalence of deprescribing of medications suitable for deprescribing, and the prevalence of new initiation of potentially inappropriate medications (PIMs) in nursing home (NH) residents...
Αλέξανδρος Γ. Σφακιανάκης
1d
Akupunktur & Aurikulomedizin
Kongress-SplitterEXPERTENKURS DAVOS 2019DICKES KNIE BEIM JOGGENA-DIPLOME ERFREUEN SICH GROSSER BELIEBTHEITFRAGEN AUS DER PRAXISMIT LASER TRADITIONELL STIMULIERENFÜR SIE GELESENInhaltsverzeichnisZEREBRALE PHOTOBIOMODULATION — VORLÄUFIGE ERGEBNISSE ZUR REGIONALEN ZEREBRALEN OXYMETRIE UND THERMISCHEN BILDGEBUNGZusammenfassungEin neues Gerät für die LED-Photobiomodulation wird vorgestellt. Vorläufige Ergebnisse der regionalen zerebralen Sauerstoffsättigung und der Thermografie werden vor, während und...
Αλέξανδρος Γ. Σφακιανάκης
1d
Drug Safety
Correction to: Benefit-Risk Assessment of Obesity Drugs: Focus on Glucagon-like Peptide-1 Receptor AgonistsIn the original publication of this article, the following correction should be noted in Table 1.A Profile of Adverse Drug Reactions of Atazanavir- and Lopinavir-Based Antiretroviral Regimens in NamibiaInflammation, Monoclonal Antibodies and Depression: Joining the DotsSirolimus and mTOR Inhibitors: A Review of Side Effects and Specific Management in Solid Organ TransplantationAbstractInhibitors...
Αλέξανδρος Γ. Σφακιανάκης
1d
Sport and Exercise
Career Performance Progressions of Junior and Senior Elite Track and Field AthletesAbstractPurposeTo compare and assess differences in the career performance progressions of elite junior and Olympic track and field athletes.MethodsAnnual best performances from top 8 men and women (e.g. finalists) in track and field events at the 2000 World Junior Championships (junior cohort) and the 2000 Olympic Games (Olympic cohort) were examined. Annual bests of these finalists were tracked each year from select...
Αλέξανδρος Γ. Σφακιανάκης
1d
Otolaryngology and Head & Neck Surgery
Endoscopic Management of Tympanic Membrane Retraction Pockets: A Two Handed Technique with Endoscope HolderAbstractThe tympanic membrane retraction pocket is a pathological invagination of tympanic membrane into the middle ear space. The most common sites for formation of retraction pocket are pars flaccida and postero-superior parts. Decision about the procedure and the timing of the treatment of retraction pockets is debatable and depends on the functional and anatomic condition of the ear. To...
Αλέξανδρος Γ. Σφακιανάκης
1d
Addiction Medicine
Patient and Physician Perspectives on Treating Tobacco Dependence in Hospitalized Smokers With Substance Use Disorders: A Mixed Methods StudyObjective: Individuals with substance use disorders have a high prevalence of smoking cigarettes. Hospitalization represents an opportunity to deliver concurrent treatment for tobacco and other substances. Using a sequential explanatory mixed methods design, we characterized practices and perspectives of patients and physicians about smoking cessation counseling...
Αλέξανδρος Γ. Σφακιανάκης
1d
Applied Magnetic Resonance
Multi-frequency Dynamic Weighted Functional Connectivity Networks for Schizophrenia DiagnosisAbstractFrequency-specific functional connectivity (FC) networks based on resting-state functional magnetic resonance imaging (rs-fMRI) have been successfully applied to the analysis and diagnosis of various mental illnesses, such as schizophrenia. However, most of the existing frequency-specific FC studies just focus on investigating the static temporal properties of FC networks, ignoring the important dynamic...
Αλέξανδρος Γ. Σφακιανάκης
1d
Oto-Rhino-Laryngology
Correction to: Two-handed tying technique in vocal fold mucosa microsuture for the treatment of Reinke's edemaIn the original publication, the patient number was incorrectly published under the "Methods" heading in the abstract section. The incorrect sentence reads as "55 patients with Reinke's edema, who were admitted from November 2010 to June 2018, were enrolled as research subjects for the retrospective analysis."Response to: Oral cancer of Sigmund FreudIn reply to Swain et al.: Re-evaluation...
Αλέξανδρος Γ. Σφακιανάκης
1d
Regenerative Engineering and Translational Medicine
Altered Biodistribution and Tissue Retention of Nanoparticles Targeted with P-Glycoprotein SubstratesAbstractLow molecular weight substrates of the efflux transporter, P-glycoprotein, alter the biodistribution and tissue retention of nanoparticles following intravenous administration. Of particular interest is the retention of the targeted nanoparticles in the brain. Drug delivery to the brain is hindered by the restricted transport of drugs through the blood-brain barrier (BBB). Drugs that passively...
Αλέξανδρος Γ. Σφακιανάκης
1d
Evidence-Based Policing
Targeting the Most Harmful Co-Offenders in Denmark: a Social Network Analysis ApproachAbstractResearch QuestionIs there a 'power few' individuals in Denmark who, through consistent co-offending, produce the highest frequency of crimes and the most harm to society amongst all co-offenders?DataWe analysed official statistics from the Police Crime Case Management System in Denmark on all 437,717 charges for violations of the Danish Criminal Code, the Illegal Substances Act and the Weapons Act, in which...
Αλέξανδρος Γ. Σφακιανάκης
1d
Phonetics
Vocal Dose for Rhythm-Based Indoor Cycling Instructors: With and Without AmplificationThe purpose of this research was to characterize the voice physiology requirements of indoor cycling instructors as measured by vocal dose (distance the vocal folds travel and average voice intensity) and perceived phonatory effort with and without amplification. Using a within-participant repeated measures design, eight rhythm-based cycling instructors were consented and scheduled to teach two ecologically valid...
Αλέξανδρος Γ. Σφακιανάκης
1d
Medicine
A Genome‐wide Association Study of Prostate Cancer in LatinosLatinos represent less than 1% of samples analyzed to date in genome‐wide association studies of cancer. The clinical value of genetic information in guiding personalized medicine in populations of non‐European ancestry will require additional discovery and risk locus characterization efforts across populations. In the present study, we performed a GWAS of PrCa in 2,820 Latino PrCa cases and 5,293 controls to search for novel PrCa risk...
Αλέξανδρος Γ. Σφακιανάκης
1d