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Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive neurodegenerative disease in which ventilatory insufficiency and other respiratory complications account for the majority of deaths. Respiratory failure is a presenting feature in about 3-5% of the patients (de Carvalho et al., 1996).
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Publication date: Available online 24 May 2018
Source:Arab Journal of Gastroenterology
Author(s): C. Díaz del Arco, M.J. Fernández Aceñero
Gastrointestinal involvement is frequent in systemic amyloidosis. However, amyloidosis can rarely be confined to the gastrointestinal tract or appear as a tumour mass. There have been few reports describing amyloid globular deposits in a variety of locations, as opposed to the usual linear ones. We herein report a rare case of globular amyloidosis involving the large bowel, which to the best of our knowledge is the second reported in the world literature.A 74-year-old man consulted on anaemia. Endoscopy showed ulcerative lesions in the left colon, which were biopsied and diagnosed as ischemic colitis. Under light microscopy, we found globular discrete deposits in the lamina propria which were Congo red-positive and resistant to permanganate digestion. Histopathological diagnosis was globular amyloidosis with AL deposits. The patient underwent further studies, including a haematologic evaluation that discarded systemic involvement.Globular amyloidosis seems to be a rare morphologic type of amyloidosis, but not a distinct entity. Its etiology, pathogenesis and relationship with patient prognosis and disease severity remain largely unknown. When amyloid deposits are confined to the gastrointestinal tract, systemic therapy can be avoided and patients should only be followed periodically. Immunohistochemical classification and clinical correlation are essential to rule out systemic amyloidosis.
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Controllers for assistive robotic devices can be divided into two main categories: controllers using neural signals and controllers using mechanically intrinsic signals. Both approaches are prevalent in resear...
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Publication date: August 2018
Source:Clinical Neurophysiology, Volume 129, Issue 8
Author(s): Joe F. Jabre
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Paramedics from several EMS agencies teaching hands-only CPR to passengers at the Dallas/Fort Worth International Airport
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EMS practitioners and billing administrators acknowledged for industry impact
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The coauthor Masashi Yoneda's affiliation has been incorrectly published in the original publication of the article. The correct affiliation is provided in this correction.
Hepatology
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European Journal of Radiology
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Acta Pediatrica
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Gastroenterology
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JAMA Dermatology
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Liver International
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Surgery
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Human Pathology
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Gastrointestinal Endoscopy
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Hepatology
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Liver International
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American Journal of Clinical Oncology
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The American Journal of Surgery
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Surgery
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Journal of Human Nutrition and Dietetics
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Clinical Infectious Diseases
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Surgery
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Clinical Radiology
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Publication date: Available online 24 May 2018
Source:International Journal of Psychophysiology
Author(s): Ferenc Kemény, Chiara Banfi, Melanie Gangl, Corinna M. Perchtold, Ilona Papousek, Kristina Moll, Karin Landerl
Findings on the neurophysiological correlates of developmental dyslexia are mixed, due to the differential conceptualization of the impairment. Studies differ on whether participants with developmental dyslexia are recruited based on reading skills only or reading as well as spelling skills. The current study contrasts the contribution of impaired reading and spelling to ERP correlates of print sensitivity, lexico-semantic access and sensitivity to orthographic regularities. Four groups of children were recruited: isolated reading deficit, isolated spelling deficit, combined reading and spelling deficit, and typically developing. Their neural correlates (EEG) of word, pseudohomophone, and pseudoword reading, as well as false font processing were compared. 1) All groups showed higher N1 amplitudes to letters than to false fonts. 2) Good spellers exhibited more negative N400 s for meaningless (pseudowords) than for meaningful stimuli (words and pseudohomophones). This effect was not observed in poor spellers. 3) Good readers showed sensitivity to orthographic regularities in a later time window (700–900 ms), whereas this was not the case for poor readers. 1) Print sensitivity is not affected by reading and/or spelling deficit in German-speaking 3rd graders. 2) Spelling deficits are associated with a reduced orthographic lexicon, 3) Reading deficits are associated with atypical use of sublexical information. As this effect was observed after lexico-semantic access, the results are discussed in terms of a possible orthographic reanalysis hypothesis.
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