Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
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Δευτέρα 23 Ιουλίου 2018
Simultaneous Preclinical Positron Emission Tomography-Magnetic Resonance Imaging Study of Lymphatic Drainage of Chelator-Free 64Cu-Labeled Nanoparticles
Simultaneous Preclinical Positron Emission Tomography-Magnetic Resonance Imaging Study of Lymphatic Drainage of Chelator-Free 64Cu-Labeled Nanoparticles
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
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Comparison of Mismatch Amplification Mutation Assay PCR and PCR-Restriction Fragment Length Polymorphism for Detection of Major Mutations in gyrA and parC of Escherichia coli Associated with Fluoroquinolone Resistance
Microbial Drug Resistance, Ahead of Print.
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Complete Sequence of a Novel Multidrug-Resistant Pseudomonas putida Strain Carrying Two Copies of qnrVC6
Microbial Drug Resistance, Ahead of Print.
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Antibacterial Activity of DC-159a Against Salmonella Typhimurium
Microbial Drug Resistance, Ahead of Print.
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Physiological Starvation Promotes Caenorhabditis elegans Vulval Induction
Studying how molecular pathways respond to ecologically relevant environmental variation is fundamental to understand organismal development and its evolution. Here we characterize how starvation modulates Caenorhabditis elegans vulval cell fate patterning-an environmentally sensitive process, with a nevertheless robust output. Past research has shown many vulval mutants affecting EGF-Ras-MAPK, Delta-Notch and Wnt pathways to be suppressed by environmental factors, such as starvation. Here we aimed to resolve previous, seemingly contradictory, observations on how starvation modulates levels of vulval induction. Using the strong starvation suppression of the Vulvaless phenotype of lin-3/egf reduction-of-function mutations as an experimental paradigm, we first tested for a possible involvement of the sensory system in relaying starvation signals to affect vulval induction: mutation of various sensory inputs, DAF-2/Insulin or DAF-7/TGF-β signaling did not abolish lin-3(rf) starvation suppression. In contrast, nutrient deprivation induced by mutation of the intestinal peptide transporter gene pept-1 or the TOR pathway component rsks-1 (the orthologue of mammalian P70S6K) very strongly suppressed lin-3(rf) mutant phenotypes. Therefore, physiologically starved animals induced by these mutations tightly recapitulated the effects of external starvation on vulval induction. While both starvation and pept-1 RNAi were sufficient to increase Ras and Notch pathway activities in vulval cells, the highly penetrant Vulvaless phenotype of a tissue-specific null allele of lin-3 was not suppressed by either condition. This and additional results indicate that partial lin-3 expression is required for starvation to affect vulval induction. These results suggest a cross-talk between nutrient deprivation, TOR-S6K and EGF-Ras-MAPK signaling during C. elegans vulval induction.
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Störungen des Kalziumhaushalts
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 516-528
DOI: 10.1055/s-0043-121655
Störungen des Kalziumhaushalts sind weit verbreitet. Ihre pathophysiologischen Ursachen sind sehr heterogen und die klinischen Symptome häufig unspezifisch. Daher ist eine genaue Diagnostik unerlässlich und ein schneller Ausgleich der Kalziumhomöostase essenziell. Dieser Artikel erörtert die pathophysiologischen, diagnostischen und therapeutischen Pfeiler von Hypo- und Hyperkalzämie sowie ihre Auswirkungen auf Anästhesie und Intensivmedizin.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Videolaryngoskopie – Ende der Fiberoptik beim erwartet schwierigen Atemweg?
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 487-488
DOI: 10.1055/a-0643-3504
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
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Störungen des Natriumhaushalts
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 492-502
DOI: 10.1055/s-0043-121662
Störungen des Natriumhaushalts sind häufig auftretende Elektrolytimbalancen. Sowohl sie selbst als auch ihre unsachgemäße Therapie können schwerwiegende Komplikationen nach sich ziehen. Der vorliegende Artikel informiert über die Ätiologie von Störungen des Natriumhaushalts und stellt wichtige therapeutische Prinzipien dar.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Vollelektrolyt- versus NaCl-Lösung in der Therapie kritisch kranker Erwachsener
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 488-488
DOI: 10.1055/a-0643-3479
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
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Orale Antikoagulanzien: Management von elektiven und Notfalleingriffen
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 543-550
DOI: 10.1055/s-0043-111006
Orale Antikoagulation bei chirurgischen Patienten erfolgt meistens mit Vitamin-K-Antagonisten (VKA) oder nicht-Vitamin-K-antagonistischen oralen Antikoagulanzien (NOAK). Während VKA wegen ihrer langen Halbwertszeit über die INR gesteuert werden, ist bei NOAK in der Regel keine Gerinnungskontrolle notwendig. Die Gabe erfolgt in festen Dosierungen. Spezifische Gerinnungswerte zur Bestimmung der Wirkung von NOAK können über die Anti-Faktor-Xa(FXa)-Aktivität (für FXa-Inhibitoren: Apixaban, Edoxaban, Rivaroxaban) und die verdünnte Thrombinzeit (für Dabigatran) erfolgen. Es gibt aktuell keine validierten Grenzwerte, die mit einem erhöhten Risiko für perioperative Blutungen einhergehen. Während VKA perioperativ auf eine parenterale Antikoagulation (z. B. niedermolekulares Heparin) umgestellt werden („Bridging"), werden NOAK pausiert. Ebenso ist nach ausreichendem Sicherheitsabstand die Durchführung von rückenmarksnahen Regionalanästhesieverfahren möglich. Falls erforderlich können NOAK auch auf ein parenterales Verfahren umgestellt werden („Switching"). Lebensbedrohliche Blutungskomplikationen können sowohl unter VKA als auch unter NOAK mit Prothrombinkomplex (PPSB) behandelt werden. Für Dabigatran steht ein Antidot zur Verfügung.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Glukokortikoid-Therapie im septischen Schock – ja oder nein?
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 489-489
DOI: 10.1055/a-0643-3451
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
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Störungen des Kaliumhaushalts
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 504-514
DOI: 10.1055/s-0043-121654
Störungen des Kaliumhaushalts sind perioperativ und beim Intensivpatienten häufig anzutreffen – sie können sich schnell zu einer akuten Lebensbedrohung entwickeln. Dieser Beitrag geht auf die physiologischen Grundlagen des Kaliumhaushalts ein und zeigt auf, wie akute Störungen behandelt werden können.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Elektrolytstörungen
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 490-491
DOI: 10.1055/a-0631-0160
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
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Neue Antibiotika für die Therapie von multiresistenten gramnegativen Bakterien
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 529-542
DOI: 10.1055/s-0043-110504
Die stetige Zunahme an bakteriellen Resistenzen und von multiresistenten Erregern (MRE) – vor allem im gramnegativen Bereich – ist ein weltweites Problem. Die Entwicklung neuer Wirkstoffe gegen Infektionen mit multiresistenten gramnegativen Erregern (MRGN) besitzt daher höchste Priorität. Im Folgenden werden kürzlich zugelassene oder in der fortgeschrittenen klinischen Prüfung befindliche Antibiotika mit Wirksamkeit gegen MRGN vorgestellt.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Versorgung von Traumapatienten mit dem „REBEL“-Set
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 551-558
DOI: 10.1055/s-0044-102122
Die zunehmende Terrorbedrohung und ein verändertes Einsatzspektrum für den Rettungsdienst erfordern eine Anpassung und Erweiterung von Notfallrettungsmitteln und Einsatztaktik. Ein Beispiel hierfür ist die bayerische „Handlungsempfehlung für Rettungsdienst bei besonderen Einsatzlagen (REBEL)". Es werden 3 Fälle vorgestellt, bei denen „neue Hilfsmittel" wie Hämostyptika, Thoraxverschlusspflaster und Tourniquet aus dem REBEL-Set bei Rettungsdiensteinsätzen angewandt wurden.
[...]
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Gefährliche Patientenübergaben!
Anästhesiol Intensivmed Notfallmed Schmerzther 2018; 53: 486-487
DOI: 10.1055/a-0643-3517
Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
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Emergency Medical Services Specialist - Napa County Human Resources
$89,627.20 - $107,806.40 Annual Apply: https://ift.tt/1fAtwme COUNTY OF NAPA AS AN EMPLOYER The County of Napa is a highly respected employer within the local community as well as throughout the region. We offer rewarding and challenging work, flexible hours, competitive salaries, a comprehensive benefits package and tremendous opportunities for career growth. At the County of Napa we truly ...
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Mechanisms of the antilipolytic response of human adipocytes to tyramine, a trace amine present in food
Abstract
Tyramine is found in foodstuffs, the richest being cheeses, sausages, and wines. Tyramine has been recognized to release catecholamines from nerve endings and to trigger hypertensive reaction. Thereby, tyramine-free diet is recommended for depressed patients treated with irreversible inhibitors of monoamine oxidases (MAO) to limit the risk of hypertension. Tyramine is a substrate of amine oxidases and also an agonist at trace amine-associated receptors. Our aim was to characterize the dose-dependent effects of tyramine on human adipocyte metabolic functions. Lipolytic activity was determined in adipocytes from human subcutaneous abdominal adipose tissue. Glycerol release was increased by a fourfold factor with classical lipolytic agents (1 μM isoprenaline, 1 mM isobutylmethylxanthine) while the amine was ineffective from 0.01 to 100 μM and hardly stimulatory at 1 mM. Tyramine exhibited a partial antilipolytic effect at 100 μM and 1 mM, which was similar to that of insulin but weaker than that obtained with agonists at purinergic A1 receptors, α2-adrenoceptors, or nicotinic acid receptors. Gi-protein blockade by Pertussis toxin abolished all these antilipolytic responses save that of tyramine. Indeed, tyramine antilipolytic effect was impaired by MAO-A inhibition. Tyramine inhibited protein tyrosine phosphatase activities in a manner sensitive to ascorbic acid and amine oxidase inhibitors. Thus, millimolar tyramine restrained lipolysis via the hydrogen peroxide it generates when oxidized by MAO. Since tyramine plasma levels have been reported to reach 0.2 μM after ingestion of 200 mg tyramine in healthy individuals, the direct effects we observed in vitro on adipocytes could be nutritionally relevant only when the MAO-dependent hepato-intestinal detoxifying system is overpassed.
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Molecular characterization and expression of suppressor of cytokine signaling (SOCS) 1, 2 and 3 under acute hypoxia and reoxygenation in pufferfish, Takifugu fasciatus
Abstract
Hypoxia seriously affects the innate immune system of fish. However, the roles of suppressor of cytokine signaling (SOCS), pivotal anti-inflammatory genes, in response to hypoxia/reoxygenation remain largely unexplored. The primary objective of this study was to elucidate the function of SOCS genes under acute hypoxia and reoxygenation in pufferfish (Takifugu fasciatus). In the present study, SOCS1, 2 and 3 were identified in T. fasciatus referred to as TfSOCS1, 2 and 3. Then, qRT-PCR and western blot analysis were employed to assess their expressions at both the mRNA and protein levels. Tissue distribution demonstrated that the three SOCS genes were predominantly distributed in gill, brain and liver. Under hypoxia challenge (1.63 ± 0.2 mg/L DO for 2, 4, 6 and 8 h), the expressions of TfSOCS1 and 3 in brain and liver at the mRNA and protein levels were significantly decreased, while their expressions showed an opposite trend in gill. Different from the expressions of TfSOCS1 and 3, the expression of TfSOCS2 was inhibited in gill, along with its increased expression in brain and liver. After normoxic recovery (7.0 ± 0.3 mg/L of DO for 4 and 12 h), most of TfSOCS genes were significantly altered at R4 (reoxygenation for 4 h) and returned to the normal level at R12 (reoxygenation for 12 h). SOCS genes played vital roles in response to hypoxia/reoxygenation challenge. Our findings greatly strengthened the relation between innate immune and hypoxia stress in T. fasciatus.
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Mass. first responders equipped with ballistic vests, helmets
The ballistic gear allows firefighters and paramedics into the "warm zone" alongside law enforcement to quickly provide life-saving first aid
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2018 Hooley awards winners announced at ImageTrend Connect
LAKEVILLE, MINN. — ImageTrend, Inc. announced the winners of the 2018 Hooley™ Awards at the 10th annual ImageTrend Connect Conference. Nominees were narrowed down to a field of nine finalists – three in each of three categories – from which the winners were selected by a panel of third-party judges. Judges cast votes via secret ballot for each category. ImageTrend extends...
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Decreasing trend of ambient dose equivalent rates over a wide area in eastern Japan until 2016 evaluated by car-borne surveys using KURAMA systems
Publication date: December 2018
Source: Journal of Environmental Radioactivity, Volume 192
Author(s): Masaki Andoh, Satoshi Mikami, Shuichi Tsuda, Tadayoshi Yoshida, Norihiro Matsuda, Kimiaki Saito
Abstract
As part of the investigation of the distribution of ambient dose equivalent rates around the Fukushima Dai-ichi Nuclear Power Plant (FDNPP), car-borne surveys using Kyoto University RAdiation MApping (KURAMA) systems have been conducted over a wide area in eastern Japan since 2011. The enormous volume of measurement data collected until 2016, including those until 2012 which were reported in the previous paper, was analyzed, and dependencies of the decreasing trend of the dose rates in regions within 80 km of the FDNPP on land-use categories, evacuation order areas and magnitude of the dose rates were examined. The air dose rates within 80 km of the FDNPP tended to decrease considerably with respect to the physical decay of radiocaesium. The decrease of the dose rate in the "forest" was slower than its decrease in other regions, while that in "urban area" was the fastest. The decrease in the air dose rate from 2011 was the fastest outside the evacuation order area until 2015, and it was the slowest in the "difficult-to-return zone". However, the decreasing trend starting from 2013 showed that the decrease in the "zone in preparation for the lifting of the evacuation order" and in the "residence restriction area" was the fastest. It was found that the air dose rates decreased depending on the magnitude of the dose rates and elapsed time from the FDNPP accident, i.e. the decrease in air dose rates in areas with relatively low dose ranges (such as 0.2–0.5 μSv/h) was the largest during a period relatively early after the accident, and the decreasing rate in the dose rate ranges of 1.9–3.8 and 3.8–9.5 μSv/h were the fastest after 2013. The averaged ratios were analyzed to obtain the ecological half-lives of the fast and slow decay components, and those in whole area within 80 km of FDNPP were estimated to be 0.44 ± 0.05 y and 6.7 ± 1 y, respectively. The ecological half-lives with respect to the land use categories, evacuation order areas and magnitude of the dose rates were also evaluated. The decrease in the dose rates obtained by the car-borne survey was larger than that obtained on flat ground with few disturbances using the NaI(Tl) survey meter during approximately 1.5 y after the FDNPP accident. Thereafter, the difference of decreasing tendencies in the air dose rates between both the measurements was negligibly small, with the ratio of dose rates by the car-borne survey to those by the fixed-point measurement of 0.72–0.77.
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Effects of ocean acidification on 109Cd, 57Co, and 134Cs bioconcentration by the European oyster (Ostrea edulis): Biokinetics and tissue-to-subcellular partitioning
Publication date: December 2018
Source: Journal of Environmental Radioactivity, Volume 192
Author(s): Narin Sezer, Önder Kılıç, Marc Metian, Murat Belivermiş
Abstract
The uptake and depuration kinetics of dissolved 109Cd, 57Co and 134Cs were determined experimentally in the European flat oyster Ostrea edulis (Linnaeus, 1758) under different pH conditions (i.e., 8.1, 7.8 and 7.5) for 59 days. Uptake and depuration rates were variable within these elements; no effects were observed under different pH conditions for the uptake biokinetics of 109Cd and 57Co and depuration of 109Cd and 134Cs in oyster. The uptake and depuration rate constants of 134Cs differed during the exposure phase between treatments, while the steady state concentration factors (CFss) were similar. The resulting Cs activity that was purged during short- and long-term depuration phases differed, while the remaining activities after thirty-nine days depuration phase (RA39d) were similar. Co-57 depuration was affected by pCO2 conditions: RA39d were found to be significantly higher in oysters reared in normocapnia (pCO2 = 350 μatm) compared to high pCO2 conditions. Co-57 tissue distribution did not differ among the variable pCO2 conditions, while 109Cd and 134Cs accumulated in soft tissue of oysters were found to be higher under the highest pCO2. Additionally, Cd, Co and Cs were stored differently in various compartments of the oyster cells, i.e. cellular debris, metal-rich granules (MRG) and metallothionein-like proteins (MTLP), respectively. The subcellular sequestration of the elements at the end of the depuration phase did not differ among pH treatments. These results suggest that bioconcentration and tissue/subcellular distribution are element-specific in the oyster, and the effects of higher pCO2 driven acidification and/or coastal acidification variably influence these processes.
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A case of inferior vena cava thrombosis caused by compression due to growing giant liver cyst
Abstract
We report a case of inferior vena cava (IVC) thrombosis caused by compression by a giant liver cyst. A 68-year-old man with a 1-day history of abdominal pain was referred to another hospital. Ultrasonography (US) and enhanced computed tomography (CT) showed a multilobular cyst on the right liver lobe that had increased to 300 mm in diameter from 90 mm 18 months earlier. Thrombosis was detected in the IVC, which was compressed by the cyst. Percutaneous transhepatic cyst drainage achieved no significant change in size. Cytological analysis from the percutaneous drainage tube fluid showed no evidence of malignancy. He was referred to our hospital for further assessment and treatment. Enhanced US using perfluorobutane, CT, and magnetic resonance imaging showed no tumorous lesions in the cyst. Thus, we diagnosed it as a multilobular cyst with no evidence of malignancy. A 3-week course of heparin resulted in the successful resolution of the thrombosis. Cystectomy was subsequently performed and pathological examination showed a multifocal cyst consisting of central suppurative inflammatory exudation and hemorrhagic material, with no malignancy. This case demonstrates that giant, expanding, non-tumorous cysts can cause IVC thrombosis. Careful treatment using heparin successfully resolved the thrombosis and allowed successful cystectomy.
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Oregon’s Expansion of Prenatal Care Improved Utilization Among Immigrant Women
Abstract
Objectives To determine whether expanding Emergency Medicaid to cover prenatal care in Oregon affected maternal health outcomes for unauthorized immigrants. Methods This study takes place in Oregon from 2003 to 2015 and includes all Emergency Medicaid and Medicaid claims for women aged 12–51 with a pregnancy related claim. To isolate the effect of expanding access to prenatal care, we utilized a difference-in-differences approach that exploits the staggered rollout of the prenatal care program. The primary outcome was a composite measure of severe maternal morbidity and mortality. Additional outcomes include adequacy of prenatal care, detection of pregnancy complications and birth outcomes. Results A total of 213,746 pregnancies were included, with 35,182 covered by Emergency Medicaid, 12,510 covered by Emergency Medicaid Plus (with prenatal care), and 166,054 covered by standard Medicaid. Emergency Medicaid Plus coverage did not affect severe maternal morbidity (all pregnancies 0.05%, CI − 0.29; 0.39; high-risk pregnancies 2.20%, CI − 0.47; 4.88). The program did reduce inadequate care among all pregnancies (− 31.75%, 95% CI − 34.47; − 29.02) and among high risk pregnancies (− 38.60%, CI − 44.17; − 33.02) and increased diagnosis of gestational diabetes (6.24%, CI 4.36; 8.13; high risk pregnancies 10.48%, CI 5.87; 15.08), and poor fetal growth (7.37%, CI 5.69; 9.05; high risk pregnancies 5.34%, CI 1.00; 9.68). The program also increased diagnosis of pre-existing diabetes mellitus (all pregnancies 2.93%, CI 2.16; 3.69), hypertensive diseases of pregnancy (all pregnancies 1.28%, CI 0.52; 2.04) and a history of preterm birth (all pregnancies 0.87%, CI 0.27; 1.47). Conclusions for Practice Oregon's prenatal care expansion program produced positive effects for unauthorized immigrant women and their children.
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Long-term outcome and recurrence of hepatitis B virus following liver transplantation from hepatitis B surface antigen-positive donors in a Chinese population
Journal of Viral Hepatitis
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Tofacitinib induction therapy reduces symptoms within 3 days for patients with ulcerative colitis
Clinical Gastroenterology and Hepatology
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Diminished circulating concentration of interleukin-35 in Helicobacter pylori-infected patients with peptic ulcer: Its association with FOXP3 gene polymorphism, bacterial virulence factor CagA, and gender of patients
Helicobacter
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Risk of fractures at different anatomic sites in patients with irritable bowel syndrome: A nationwide population-based cohort study
Archives of Osteoporosis
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2018 EMS Trend Report: How the optimism divide will shape EMS' future
EMS1 and Fitch & Associates take an in-depth look at EMS trends in the United States and set a foundation for assessing how the EMS profession is changing
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Identification and expression of genes in response to cassava bacterial blight infection
Abstract
Cassava bacterial blight (CBB) caused by Xanthomonas axonopodis pv. manihotis (or XAM) is a serious disease of cassava (Manihot esculenta Crantz). In this study, quantitative trait loci (QTL) associated with CBB infection were identified in the F1 progenies of a cross between the "Huay Bong 60" and "Hanatee" cassava cultivars. The phenotype of disease severity was observed at 7, 10, and 12 days after inoculation (DAI). A total of 12 QTL were identified, of which 5, 6, and 1 were detected in 7, 10, and 12 DAI samples, respectively. Among all identified QTL, CBB14_10dai_1, CBB14_10dai_2, and CBB14_12dai showed the most significant (P < 0.0001) associations with CBB infection, and explained 21.3, 13.8, and 26.5% of phenotypic variation, respectively. Genes underlying the QTL were identified and their expression was investigated in resistant and susceptible cassava plants by real-time quantitative RT-PCR. The results identified candidate genes that showed significant differences in expression between resistant and susceptible lines, including brassinosteroid insensitive 1-associated receptor kinase 1-related (Manes.04G059100), cyclic nucleotide-gated ion channel 2 (Manes.02G051100), and autophagy-related protein 8a-related (Manes.17G026600) at 7 DAI, and regulator of nonsense transcripts 1 homolog (Manes.17G021900) at both 7 and 12 DAI. The expression pattern of all genes showed higher levels in resistant (B82, B32, B20, and B70) as compared to susceptible (HB60, B100, B95, and B47) plants. Overall, this study has identified QTL and markers linked to CBB infection trait, and identified candidate genes involved in CBB resistance. This information will be of use for better understanding defense mechanisms in cassava to bacterial blight disease.
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