Κυριακή 16 Ιουλίου 2017

Non-coding RNA: A protective role for TERRA at telomeres

Nature Reviews Genetics 18, 453 (2017). doi:10.1038/nrg.2017.58

Author: Linda Koch

From yeast to humans, telomeric DNA is transcribed by RNA polymerase II into the long non-coding (lnc) telomeric repeat-containing RNA (TERRA), but the exact functions of this RNA and its mode of action have remained poorly understood. Two studies in Cell now reveal a



from Genetics via xlomafota13 on Inoreader http://ift.tt/2thUccy
via IFTTT

Gene expression: Microglia — environment defines identity

Nature Reviews Genetics 18, 454 (2017). doi:10.1038/nrg.2017.55

Author: Michelle Trenkmann

Microglia are macrophage cells of the central nervous system (CNS) with crucial functions in neurodevelopment, immunity and tissue homeostasis, but this cell population has been notoriously difficult to study. A new study in Science describes the transcriptomic and epigenomic profiles of cortical microglia ex



from Genetics via xlomafota13 on Inoreader http://ift.tt/2shMASW
via IFTTT

Cancer genetics: A 3D view of genome rearrangements

Nature Reviews Genetics 18, 456 (2017). doi:10.1038/nrg.2017.56

Author: Linda Koch

Somatic structural genome alterations such as changes in copy number or chromosomal rearrangements can promote genome instability and cancer development, and identification of these mutations is crucial to diagnose cancer early and provide targeted therapies. Now, Harewood et al. report the use of Hi-C



from Genetics via xlomafota13 on Inoreader http://ift.tt/2shVFLE
via IFTTT

Cancer epigenetics: Therapy-induced transcription is cryptically widespread

Nature Reviews Genetics 18, 455 (2017). doi:10.1038/nrg.2017.53

Author: Darren J. Burgess

The observations of abnormal epigenomes in cancer has motivated the pursuit of epigenome-targeted drugs for cancer therapy, but despite the clinical approval of various drugs, their cellular mechanisms of action are only partially understood. A new study demonstrates that DNA methyltransferase inhibitors (DNMTi) and histone



from Genetics via xlomafota13 on Inoreader http://ift.tt/2tKZJVN
via IFTTT

Disease genetics: Repeat expansion disorders — going through a phase

Nature Reviews Genetics 18, 454 (2017). doi:10.1038/nrg.2017.54

Author: Dorothy Clyde

Some common inherited diseases are caused by nucleotide repeat expansions, whereby disease occurs only when the number of repeats exceeds a critical threshold. However, the underlying molecular mechanism linking repeat number to pathology has remained elusive. A recent study provides new insight by demonstrating that



from Genetics via xlomafota13 on Inoreader http://ift.tt/2tLrPjU
via IFTTT

Reference standards for next-generation sequencing

Nature Reviews Genetics 18, 473 (2017). doi:10.1038/nrg.2017.44

Authors: Simon A. Hardwick, Ira W. Deveson & Tim R. Mercer

Next-generation sequencing (NGS) provides a broad investigation of the genome, and it is being readily applied for the diagnosis of disease-associated genetic features. However, the interpretation of NGS data remains challenging owing to the size and complexity of the genome and the technical errors that



from Genetics via xlomafota13 on Inoreader http://ift.tt/2rGMBDE
via IFTTT

Technique: Sizing up tumours with Tuba-seq

Nature Reviews Genetics 18, 456 (2017). doi:10.1038/nrg.2017.50

Author: Michelle Trenkmann

Precise determination of tumour growth is a prerequisite for estimating the functional importance of tumour suppressor alterations in cancer. A study in Nature Methods now describes the development of Tuba-seq, an approach that integrates tumour barcoding with high-throughput sequencing, to precisely quantify the size



from Genetics via xlomafota13 on Inoreader http://ift.tt/2tbnUf4
via IFTTT

Human Y-chromosome variation in the genome-sequencing era

Nature Reviews Genetics 18, 485 (2017). doi:10.1038/nrg.2017.36

Authors: Mark A. Jobling & Chris Tyler-Smith

The properties of the human Y chromosome – namely, male specificity, haploidy and escape from crossing over — make it an unusual component of the genome, and have led to its genetic variation becoming a key part of studies of human evolution, population history, genealogy,



from Genetics via xlomafota13 on Inoreader http://ift.tt/2riMZqw
via IFTTT

Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells

Nature Reviews Genetics 18, 457 (2017). doi:10.1038/nrg.2017.28

Authors: Olivier Cuvier & Beat Fierz

The establishment and maintenance of chromatin states involves multiscale dynamic processes integrating transcription factor and multiprotein effector dynamics, cycles of chemical chromatin modifications, and chromatin structural organization. Recent developments in genomic technologies are emerging that are enabling a view beyond ensemble- and time-averaged properties and



from Genetics via xlomafota13 on Inoreader http://ift.tt/2qb2Ins
via IFTTT

The origin of Metazoa: a unicellular perspective

Nature Reviews Genetics 18, 498 (2017). doi:10.1038/nrg.2017.21

Authors: Arnau Sebé-Pedrós, Bernard M. Degnan & Iñaki Ruiz-Trillo

The first animals evolved from an unknown single-celled ancestor in the Precambrian period. Recently, the identification and characterization of the genomic and cellular traits of the protists most closely related to animals have shed light on the origin of animals. Comparisons of animals with these



from Genetics via xlomafota13 on Inoreader http://ift.tt/2pRRHdV
via IFTTT

Non-coding RNA: A protective role for TERRA at telomeres

From yeast to humans, telomeric DNA is transcribed by RNA polymerase II into the long non-coding (lnc) telomeric repeat-containing RNA (TERRA), but the exact functions of this RNA and its mode of action have remained poorly understood. Two studies in Cell now reveal a

from Genetics via xlomafota13 on Inoreader http://ift.tt/2uzf27Q
via IFTTT

Issue Information - Editorial Board



from Genetics via xlomafota13 on Inoreader http://ift.tt/2tvjU91
via IFTTT

Preoperative clinic: Non-essential cost or catalyst for process efficiency, safety and care outcomes?

As the inevitable consequences of healthcare reform legislations are hitting the bottom line of hospitals, perioperative communities are undergoing continued intense scrutiny for opportunities to improve efficiency, safety and patient centered care. In the current issue of JCA Epstein and colleagues [1] studied the effect of bypassing an anesthesiologist-directed preoperative evaluation clinic on first-case tardiness and turnover times. In their institution, efforts to reduce cost increasingly directed patients away from their anesthesiologist-directed preoperative clinic.

from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/2v7w3Tw
via IFTTT

Determination of chemical forms of 14C in liquid discharges from nuclear power plants

S0265931X.gif

Publication date: October 2017
Source:Journal of Environmental Radioactivity, Volume 177
Author(s): I. Svetlik, M. Fejgl, P.P. Povinec, T. Kořínková, L. Tomášková, J. Pospíchal, M. Kurfiřt, R. Striegler, M. Kaufmanová
Developments of radioanalytical methods for determination of radiocarbon in wastewaters from nuclear power plants (NPP) with pressurized light water reactors, which would distinguish between the dissolved organic and inorganic forms have been carried out. After preliminary tests, the method was used to process pilot samples from wastewater outlets from the Temelín and Dukovany NPPs (Czech Republic). The results of analysis of pilot water samples collected in 2015 indicate that the instantaneous 14C releases into the water streams would be about 7.10−5 (Temelín) and 4.10−6 (Dukovany) of the total quantity of the 14C liberated into the environment.



from Radiology via xlomafota13 on Inoreader http://ift.tt/2v6uAwM
via IFTTT