Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026: 09/26/18

Τετάρτη 26 Σεπτεμβρίου 2018

Hemodynamics of tonic immobility in the American alligator ( Alligator mississippiensis ) identified through Doppler ultrasonography

Abstract

American alligators (Alligator mississippiensis) held inverted exhibit tonic immobility, combining unresponsiveness with flaccid paralysis. We hypothesize that inverting the alligator causes a gravitationally promoted increase in right aortic blood flowing through the foramen of Panizza, with a concurrent decrease in blood flow through the primary carotid, and thereby of cerebral perfusion. Inverting the alligator results in displacement of the liver, post-pulmonary septum, and the heart. EKG analysis revealed a significant decrease in heart rate following inversion; this decrease was maintained for approximately 45 s after inversion which is in general agreement with the total duration of tonic immobility in alligators (49 s). Doppler ultrasonography revealed that following inversion of the alligator, there was a reversal in direction of blood flow through the foramen of Panizza, and this blood flow had a significant increase in velocity (compared to the foraminal flow in the prone alligator). There was an associated significant decrease in the velocity of blood flow through the primary carotid artery once the alligator was held in the supine position. Tonic immobility in the alligator appears to be a form of vasovagal syncope which arises, in part, from the unique features of the crocodilian heart.

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The Correlation of Visfatin and Its Gene Polymorphism with Non-Small Cell Lung Cancer

Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.

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Emergence of CMY-2-Producing Salmonella Heidelberg Associated with IncI1 Plasmids Isolated from Poultry in Brazil

Microbial Drug Resistance, Ahead of Print.

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Genetic Diversity and Prevalence of Nontuberculous Mycobacteria Isolated from Clinical Samples in Tehran, Iran

Microbial Drug Resistance, Ahead of Print.

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Colistin- and Carbapenem-Resistant Klebsiella pneumoniae Clinical_Isolates: Algeria

Microbial Drug Resistance, Ahead of Print.

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Discovery of Anthocyanin Acyltransferase1 (AAT1) in Maize Using Genotyping-by-Sequencing (GBS)

The reduced acylation phenotype describes the inability of certain accessions of maize (Zea mays [L.]) to produce significant amounts of acylated anthocyanins, which are typically the most abundant pigments. Acylated anthocyanins are important for their association with stability and are therefore important for the various industries using anthocyanins as natural colorants to replace synthetic dyes. Many anthocyanin acyltransferases have been characterized in other species; however, no anthocyanin acyltransferases have been characterized in maize. Therefore, a mapping population was developed from a cross between mutant stock 707G and wild-type acylation line B73 to identify the locus associated with the reduced acylation trait. High-performance liquid chromatography was used to assay the pigment content and composition of 129 F₂ lines generated in the mapping population. Recessive alleles of Colorless1, Colored1, and the reduced acylation mutant all decreased anthocyanin content while Intensifier1 increased anthocyanin content in aleurone tissue. The association of increased proportions of acylation with increased anthocyanin content indicates acylation may be important for increasing the stability of anthocyanins in vivo. Genotyping-by-sequencing was used to create SNP markers to map the reduced acylation locus. In the QTL analysis, a segment of Chromosome 1 containing transferase family protein GRMZM2G387394 was found to be significant. A UniformMu Mu transposon knockout of GRMZM2G387394 demonstrated this gene has anthocyanidin malonyltransferase activity and will therefore be named Anthocyanin Acyltransferase1 (AAT1). AAT1 is the first anthocyanin acyltransferase characterized in a monocot species and will increase our knowledge of all acyltransferase family members.

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Sensor-based postural feedback is more effective than conventional feedback to improve lumbopelvic movement control in patients with chronic low back pain: a randomised controlled trial

Improving movement control can be an important treatment goal for patients with chronic low back pain (CLBP). Although external feedback is essential when learning new movement skills, many aspects of feedback...

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EMS community donates clothing, boots and money to paramedic students in need

EMS professionals, educators rally to support and "take care of the next generation of providers"

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Efficient construction of Streptococcus anginosus mutants in strains of clinical origin

Abstract

Streptococcus anginosus group (SAG) is Gram-positive bacteria responsible for a number of purulent human infections such as brain and liver abscesses, which have been on the rise for last few decades. Although some virulence factors of SAG are described, they are mostly undefined and there are almost no methods for genetic manipulations of clinical SAG. Therefore, we presented various approaches to produce engineered strains of this poorly known group of streptococci. We developed a procedure of transformation characterized by transformation efficiency at the level of 10⁴ per 1 μg DNA for certain strains. Moreover, mutagenesis for many SAG strain is possible based on the process of natural transformation. However, the usefulness of methods and their effectiveness are strain dependent.

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THE RELATIONSHIP BETWEEN SLEEP DISTURBANCE, AND DISEASE ACTIVITY IN PEDIATRIC PATIENTS WITH INFLAMMATORY BOWEL DISEASE

Objective: The aim of this prospective cross sectional study was to assess the prevalence of sleep disturbance in children with inflammatory bowel disease (IBD), including the relationships between sleep, inflammatory markers, and disease activity of pediatric patients with IBD. Methods: Pediatric IBD patients and parents were enrolled in the study. Patients completed the Pittsburgh Sleep Quality Index (PSQI), the Pediatric Daytime Sleepiness Scale (PDSS), and the Adolescent Sleep Wake Scale (ASWS) surveys. Parents completed the Child Sleep Habits Questionnaire (CSHQ). Disease activity for Crohn's disease (CD) was determined by the Pediatric Crohn's Disease Activity Index (PCDAI) and the Pediatric Ulcerative Colitis Activity Index (PUCAI) was used to define disease activity in UC/indeterminate colitis patients. Results: Fifty-three pediatric patients with IBD (38 CD, 12 UC and 3 Indeterminate colitis) participated in the study. The significant correlations between the CSHQ and PCDAI (p = 0.002) and the PSQI and PUCAI (p = 0.04) were found. Youth with UC and indeterminate colitis significantly reported more sleep disturbance than patients with CD, (p = 0.03, 0.05, and 0.04; PSQI, PDSS, ASWS, respectively). Patients self reported significantly more sleep disturbance than was observed by parents (p

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Chronic Acalculous Cholecystitis in Children with Biliary Symptoms: Usefulness of Hepato-Cholescintigraphy

Objectives: Chronic acalculous cholecystitis (CAC) increasingly is being diagnosed as a cause of recurring biliary symptoms in children, but its clinical diagnosis remains challenging. The primary objective was to evaluate the utility of hepato-cholescintigraphy in pediatric patients with suspected CAC. A secondary objective was to describe their clinical follow-up after diagnosis. Methods: Medical records of patients (aged 9–20 years) who underwent hepato-cholescintigraphy from February 2008 to January 2012 were reviewed. Patients with gallstones, and with ≤1 year of clinical follow-up, and studies without gallbladder (GB) stimulation were excluded. GB ejection fraction (GBEF) of

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Is Tube Thermosoftening Helpful for Videolaryngoscope-Guided Nasotracheal Intubation?: A Randomized Controlled Trial.

Is Tube Thermosoftening Helpful for Videolaryngoscope-Guided Nasotracheal Intubation?: A Randomized Controlled Trial.

Anesth Analg. 2018 Sep 24;:

Authors: Kim EM, Chung MH, Lee MH, Choi EM, Jun IJ, Yun TH, Ko YK, Kim JH, Jun JH

Abstract
BACKGROUND: Thermosoftening of the endotracheal tube (ETT) and telescoping the ETT into a rubber catheter have been suggested as a method for reducing epistaxis during nasotracheal intubation (NTI). However, thermosoftening technique is known to make it difficult to navigate the ETT into trachea without the use of Magill forceps during NTI. The cuff inflation technique has been suggested as an effective alternative to the use of Magill forceps to improve the oropharyngeal navigation of the ETT, irrespective of their stiffness, during direct laryngoscope-guided NTI. We evaluated whether thermosoftening of the ETT telescoped into rubber catheters has an additional benefit in reducing nasal injury. Simultaneously, we also evaluated whether thermosoftening of the ETT worsened orotracheal navigability during cuff inflation-supplemented videolaryngoscope-guided NTI.
METHODS: One hundred forty patients were randomly assigned to 1 of the 2 groups depending on whether the ETT was softened by warming or not. The primary outcome was the incidence of epistaxis during NTI. The secondary outcome was nasotracheal navigability of the ETT, assessed by navigation grade and time required for insertion of ETT in each phase (from nose to oropharynx, from oropharynx to glottic inlet aided by cuff inflation if needed, and from glottic inlet to trachea).
RESULTS: The ETTs were successfully inserted through the selected nostril of all 140 patients. In the thermosoftening group, the incidence and severity of epistaxis was significantly lower (7% vs 51%; difference of 44.2%; 95% confidence interval, 29.9%-56.2%; P < .001), and the ETT passed through the nasal cavity with lower resistance (P = .001) and less time (P < .001) when compared to the control group. No difference was found in the ease of ETT insertion (navigation grade and time required) from the oropharynx to the glottic inlet (P > .99 and P = .054, respectively) and from the glottic inlet to the trachea (P > .99 and P = .750, respectively) between the 2 groups. In both groups, all ETTs could be navigated into the trachea without the use of Magill forceps.
CONCLUSIONS: Supplemented with cuff inflation during videolaryngoscope-guided NTI, thermosoftening of the ETT telescoped into rubber catheters has a substantial benefit because it significantly reduces the incidence of epistaxis without worsening the oropharyngeal navigability of the ETT.

PMID: 30252708 [PubMed - as supplied by publisher]

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EMS community donates clothing, boots and money to paramedic students in need

EMS professionals, educators rally to support and "take care of the next generation of providers"

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Acela Truck Company expands it's line of high water/flood rescue trucks

BOZEMAN, Mont. — Acela Truck Company recently announced that it has expanded its purpose-built High Water/Flood Rescue Truck line of response apparatus to include multiple new custom body configurations and larger 6x6 models of its Monterra high mobility chassis. Flooding is the leading cause of disaster or weather-related deaths in the United States and the number of coastal and inland...

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Superficial non-ampullary duodenal cancer identified by small-bowel capsule endoscopy: a case report (with video)

Abstract

Herein, we report for the first time a case of a surficial superficial non-ampullary duodenal cancer causing obscure intestinal bleeding that was identified by small-bowel capsule endoscopy and treated by endoscopic mucosal resection. A 73-year-old man underwent upper gastrointestinal endoscopy to identify the cause of anemia. Although conventional duodenoscopy revealed a flat, elevated 5-mm lesion with a central recess and "milk-white mucosa" at the inferior duodenal angulus, capsule endoscopy revealed a white nodular 5-mm lesion with central recess at the duodenum slightly to the anal side from the major duodenal papilla. Pathohistological examination revealed a low-grade well-differentiated tubular adenocarcinoma growing locally in the mucosal layer. Although capsule endoscopy detected a nodular lesion, conventional endoscopy revealed a flat, elevated lesion. The cause of this difference in endoscopic findings is considered to be the degree of extension of the intestinal mucosa. In contrast, "milk-white mucosa" as a typical finding of superficial duodenal tumor in conventional endoscopy could be identified as a white mucosal color tone in capsule endoscopy. Conventional endoscopic findings of irregular surface structure in the lesion suggested malignancy. Pathohistologically, the ductal structure of the adenocarcinoma was also distorted. Unfortunately, it was difficult to suggest that the lesion was adenocarcinoma based on the endoscopic findings alone.

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Executive Director - Simsbury Vol. Ambulance Asso.

SVAA Mission: The Simsbury Volunteer Ambulance Association is a non-profit organization serving the emergency medical needs for the Town of Simsbury, CT. The Mission of SVAA is to continue to deliver the highest quality of emergency medical care to the town with a 100% response rate on first calls, while adhering to all state and local medical compliance regulations. Position Summary: The Executive ...

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Electrophysiological underpinnings of response variability in the Go/NoGo task

Publication date: Available online 26 September 2018

Source: International Journal of Psychophysiology

Author(s): Diana Karamacoska, Robert J. Barry, Genevieve Z. Steiner

Abstract

Response variability has been identified as a useful predictor of executive function and performance in non-clinical samples in the Go/NoGo task. The present study explores the utility of reaction time variability (RTV) and EEG measures as predictors of Go/NoGo performance outcomes and ERP component amplitudes. Forty-four young adults had EEG recorded across eyes-closed (EC) and eyes-open (EO) resting states, and during an auditory Go/NoGo task. The 18 individuals with the lowest/highest RTV were assessed for differences in behavioural outcomes. As expected, individuals with high RTV committed more Go/NoGo errors and had smaller Go P3b and NoGo P3a amplitudes, and greater Go Slow Wave positivity, reflecting inefficient decision-making and response control efforts underlying performance. When RTV and EEG measures were modelled as predictors of Go/NoGo responses, RTV and task-related changes in delta were identified as positive predictors of Go SW amplitude; while RTV and prestimulus delta amplitudes negatively predicted NoGo accuracy rates. Prestimulus delta was also found to solely predict Go mean RT and NoGo SW negativity; effects that were independent of RTV. As delta has been implicated in attention-related mechanisms, these findings suggest that inadequate attention and task engagement underpin the variability in Go/NoGo performance.

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