THE RELATIONSHIP BETWEEN SLEEP DISTURBANCE, AND DISEASE ACTIVITY IN PEDIATRIC PATIENTS WITH INFLAMMATORY BOWEL DISEASE

Objective: The aim of this prospective cross sectional study was to assess the prevalence of sleep disturbance in children with inflammatory bowel disease (IBD), including the relationships between sleep, inflammatory markers, and disease activity of pediatric patients with IBD. Methods: Pediatric IBD patients and parents were enrolled in the study. Patients completed the Pittsburgh Sleep Quality Index (PSQI), the Pediatric Daytime Sleepiness Scale (PDSS), and the Adolescent Sleep Wake Scale (ASWS) surveys. Parents completed the Child Sleep Habits Questionnaire (CSHQ). Disease activity for Crohn's disease (CD) was determined by the Pediatric Crohn's Disease Activity Index (PCDAI) and the Pediatric Ulcerative Colitis Activity Index (PUCAI) was used to define disease activity in UC/indeterminate colitis patients. Results: Fifty-three pediatric patients with IBD (38 CD, 12 UC and 3 Indeterminate colitis) participated in the study. The significant correlations between the CSHQ and PCDAI (p = 0.002) and the PSQI and PUCAI (p = 0.04) were found. Youth with UC and indeterminate colitis significantly reported more sleep disturbance than patients with CD, (p = 0.03, 0.05, and 0.04; PSQI, PDSS, ASWS, respectively). Patients self reported significantly more sleep disturbance than was observed by parents (p 

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