Σάββατο, 25 Μαΐου 2019

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,


Swallowing Skills and Aspiration Risk Following Treatment of Head and Neck Cancers Authors Authors and...
Swallowing Skills and Aspiration Risk Following Treatment of Head and Neck CancersAuthorsAuthors and affiliationsMansi JagtapEmail authorMansi Karnad1.Original ArticleFirst Online: 16 March 20195DownloadsAbstractSurgical resection and chemoradiation are common modalities of treatment in head and neck cancers. Dysphagia is one of the common complications following these interventions. The severity of dysphagia depends on various factors, site and extent of resection, and radiation therapy to highlight...
Αλέξανδρος Γ. Σφακιανάκης
1m
Laparoscopic Ovarian Transposition in Rectal Cancer: More than Just Oncological Outcomes Abstract...
Laparoscopic Ovarian Transposition in Rectal Cancer: More than Just Oncological OutcomesAbstractLocally advanced rectal cancer (LARC) is treated with neoadjuvant chemoradiotherapy which down stages tumor and improves complete resection rates thus reducing local recurrences. Pelvic radiotherapy improves oncological outcomes; however, it is associated with ovarian irradiation and premature menopause. This has a consequence to fertility and hormone preservation in young women diagnosed with locally...
Αλέξανδρος Γ. Σφακιανάκης
1m
Papillary Carcinoma in Thyroglossal Cyst: an Unusual Case Authors Authors and affiliations Amitabh JenaRashmi...
Papillary Carcinoma in Thyroglossal Cyst: an Unusual CaseAuthorsAuthors and affiliationsAmitabh JenaRashmi PatnayakEmail authorSubhashree SantisudhaJitendra Narayan SenapatiJyotiranjan PaniAdya kinkara Panda1.2.3.4.Case ReportFirst Online: 15 March 2019AbstractMalignancy developing in thyroglossal cysts is very rare. Papillary carcinoma is the most common histopathological type of carcinoma encountered in thyroglossal cysts followed by squamous cell carcinoma. A 50-year-old male presented with a...
Αλέξανδρος Γ. Σφακιανάκης
2m
Late Presentation of Chronic-Organised Biloma Masquerading as Gallbladder Fossa Mass Years After Cholecystectomy:...
Late Presentation of Chronic-Organised Biloma Masquerading as Gallbladder Fossa Mass Years After Cholecystectomy: a Diagnostic EnigmaAuthorsAuthors and affiliationsRigved Gupta1Email authorView author's OrcID profileManoj Andley1Rahul Pusuluri1Ajay Kumar11.Department of SurgeryLady Hardinge Medical College & Smt. Sucheta Kriplani HospitalNew DelhiIndiaCase ReportFirst Online: 11 December 20185DownloadsIntroductionPost-cholecystectomy bile leaks have varied presentations. It may be detected intra-operatively...
Αλέξανδρος Γ. Σφακιανάκης
2m
Primary Malignant Peripheral Nerve Sheath Tumor of the Trachea: a Case Report with Brief Review of...
Primary Malignant Peripheral Nerve Sheath Tumor of the Trachea: a Case Report with Brief Review of LiteratureAbstractMalignant schwannoma, also called malignant peripheral nerve sheath tumor (MPNST), is a rare and aggressive tumor arising from the nerve sheath. We describe a rare case of endotracheal malignant peripheral nerve sheath tumor occurring in a middle-aged male who presented with asthma-like symptoms for 6 months with progressively increasing dyspnea. A computed tomogram (CT) scan of the...
Αλέξανδρος Γ. Σφακιανάκης
3m
A Leiomyosarcoma of Inferior Vena Cava Presenting as a Liver Metastasis Mass in a Patient with History...
A Leiomyosarcoma of Inferior Vena Cava Presenting as a Liver Metastasis Mass in a Patient with History of Transitional Cell CarcinomaAbstractThe most probable diagnosis for a newly detected mass in the cancer patients is secondary metastasis. However, the multiple primary tumors should not be off the table of diagnoses. In this study, a 70-year-old man with the history of transitional cell carcinoma (TCC) was reported who had been referred due to a newly detected mass in the hepatic segment one which...
Αλέξανδρος Γ. Σφακιανάκης
3m
Isolated Midbrain Metastasis from Breast Cancer: a Classic Spotter Diagnosis Abstract Isolated midbrain...
Isolated Midbrain Metastasis from Breast Cancer: a Classic Spotter DiagnosisAbstractIsolated midbrain metastasis from breast cancer is a rare occurrence. We present a classical clinical image of a woman who presented with breast cancer with synchronous isolated midbrain metastasis.
Αλέξανδρος Γ. Σφακιανάκης
4m
Donut Mastopexy Lumpectomy Abstract Advancements in oncoplastic techniques have enhanced commitment...
Donut Mastopexy LumpectomyAbstractAdvancements in oncoplastic techniques have enhanced commitment to restore shape and, hence, has improved cosmetic outcomes. Donut mastopexy lumpectomy is one such technique and is best utilized in a setting of a malignancy not extending to the skin or the nipple-areolar complex. As a potential alternative to standard lumpectomy, it has many advantages including restriction of scar to the periareolar region, ease and rapidity of surgery, retention of nipple-areolar...
Αλέξανδρος Γ. Σφακιανάκης
4m
Malignant Melanoma: Autoimmunity and Supracellular Messaging as New Therapeutic Approaches Opinion...
Malignant Melanoma: Autoimmunity and Supracellular Messaging as New Therapeutic ApproachesOpinion statementMelanoma is one of the most aggressive forms of cancer, with a high mortality rate in the absence of a safe and curable therapy. As a consequence, several procedures have been tested over time, with the most recent (immunological and targeted) therapies proving to be effective in some patients. Unfortunately, these new treatment options continue to generate debate related to the therapeutic...
Αλέξανδρος Γ. Σφακιανάκης
4m
Pain in Cancer Survivors: How to Manage Opinion statement Managing pain in cancer survivors requires...
Pain in Cancer Survivors: How to ManageOpinion statementManaging pain in cancer survivors requires that oncologists understand the common painful syndromes that can occur from treatment or disease. Assessment no longer singularly focuses on pain characteristics (e.g., intensity, quality, location), now incorporating a strong focus on functional impairment and potential improvement that might occur with adequate treatment. Improvement in function is now the goal used to measure success. In addition,...
Αλέξανδρος Γ. Σφακιανάκης
5m
Cancer and Coronary Artery Disease: Common Associations, Diagnosis and Management Challenges Opinion...
Cancer and Coronary Artery Disease: Common Associations, Diagnosis and Management ChallengesOpinion statementCoronary artery disease (CAD) and cancer often occur in the same patients via common biological pathways and shared risk factors. A variety of chemotherapeutic agents and radiotherapy can influence the development and progression of CAD. The diagnosis of ischaemic heart disease may be challenging in certain cases such as premature CAD secondary to radiotherapy. The management of CAD in cancer...
Αλέξανδρος Γ. Σφακιανάκης
5m
Cardiotoxicity of Contemporary Breast Cancer Treatments Opinion statement Treatment-related cardiotoxicity...
Cardiotoxicity of Contemporary Breast Cancer TreatmentsOpinion statementTreatment-related cardiotoxicity remains a significant concern for breast cancer patients undergoing cancer treatment and extends into the survivorship period, with adverse cardiovascular (CV) outcomes further compounded by the presence of pre-existing CV disease or traditional CV risk factors. Awareness of the cardiotoxicity profiles of contemporary breast cancer treatments and optimization of CV risk factors are crucial in...
Αλέξανδρος Γ. Σφακιανάκης
5m
Multimodality Therapy of Patients with Refractory Meningiomas Opinion statement Recurrent and refractory...
Multimodality Therapy of Patients with Refractory MeningiomasOpinion statementRecurrent and refractory meningiomas are a clinical challenge and treatment at the time of recurrence is not well delineated. Treatment with surgery and/or radiation remain the mainstay, but each has their limitations and risks. The search for an adjuvant systemic therapy continues and as many of the initially promising approaches have not had reproducible responses. Bevacizumab has shown some efficacy in controlling recurrent...
Αλέξανδρος Γ. Σφακιανάκης
5m
The Role of CDK4/6 Inhibitors in Breast Cancer Opinion statement Oral inhibitors of CDK4/6 have been...
The Role of CDK4/6 Inhibitors in Breast CancerOpinion statementOral inhibitors of CDK4/6 have been shown to increase response rates and prolong disease control when combined with endocrine therapy in hormone-responsive (HR+) HER2-negative advanced breast cancer. Palbociclib, ribociclib and abemaciclib are all approved in combination with non-steroidal aromatase inhibitors in first-line therapy for post-menopausal women, with a 40–45% improvement in progression-free survival seen with the addition...
Αλέξανδρος Γ. Σφακιανάκης
6m
Diagnosis and Management of Subcutaneous Soft Tissue Sarcoma Opinion statement The proper diagnosis...
Diagnosis and Management of Subcutaneous Soft Tissue SarcomaOpinion statementThe proper diagnosis and treatment planning for subcutaneous soft tissue sarcoma is very important. Soft tissue tumors can occur anywhere in the body, but if they occur subcutaneously, patients can easily notice a subcutaneous soft tissue mass. Therefore, it is possible to determine through recording, the growth speed of the mass, which is often difficult to obtain with deep-situated soft tissue masses. Palpation can also...
Αλέξανδρος Γ. Σφακιανάκης
6m
Pediatric Cardio-Oncology: Development of Cancer Treatment-Related Cardiotoxicity and the Therapeutic...
Pediatric Cardio-Oncology: Development of Cancer Treatment-Related Cardiotoxicity and the Therapeutic Approach to Affected PatientsOpinion statementThe past 5 decades have seen significant improvements in outcomes for pediatric patients with cancer. Unfortunately, children and adolescents who have been treated for cancer are five to six times more likely to develop cardiovascular disease as a result of their therapies. Cardiovascular disease may manifest in a plethora of ways, from asymptomatic ventricular...
Αλέξανδρος Γ. Σφακιανάκης
6m
QT Interval Prolongation Associated With Cytotoxic and Targeted Cancer Therapeutics Opinion statement...
QT Interval Prolongation Associated With Cytotoxic and Targeted Cancer TherapeuticsOpinion statementCardiovascular toxicities are potentially serious treatment limiting complications of many different cancer therapeutics including traditional cytotoxic chemotherapies as well as targeted- and immunotherapies. As a result, there is increased monitoring for cancer treatment-related cardiotoxicities, ranging from heart failure to arrhythmias. Many anticancer treatments are known to prolong the QT interval...
Αλέξανδρος Γ. Σφακιανάκης
6m
Surgical Oncology
Correction to: Desk of the Editor Vol. 9 Issue 4Due to an unfortunate error in the email address of the corresponding author, this correction paper is being published.Donut Mastopexy LumpectomyAbstractAdvancements in oncoplastic techniques have enhanced commitment to restore shape and, hence, has improved cosmetic outcomes. Donut mastopexy lumpectomy is one such technique and is best utilized in a setting of a malignancy not extending to the skin or the nipple-areolar complex. As a potential alternative...
Αλέξανδρος Γ. Σφακιανάκης
7m
Current Treatment Options in Oncology
QT Interval Prolongation Associated With Cytotoxic and Targeted Cancer TherapeuticsOpinion statementCardiovascular toxicities are potentially serious treatment limiting complications of many different cancer therapeutics including traditional cytotoxic chemotherapies as well as targeted- and immunotherapies. As a result, there is increased monitoring for cancer treatment-related cardiotoxicities, ranging from heart failure to arrhythmias. Many anticancer treatments are known to prolong the QT interval...
Αλέξανδρος Γ. Σφακιανάκης
7m
Environmental Sciences
Effect of amendments on the leaching behavior of alkaline anions and metal ions in bauxite residuePublication date: November 2019Source: Journal of Environmental Sciences, Volume 85Author(s): Tao Tian, Jingju Zhou, Feng Zhu, Yuzhen Ye, Ying Guo, William Hartley, Shengguo XueAbstractA column leaching experiment was used to investigate the efficacy of amendments on their ability to remove alkaline anions and metal ions from bauxite residue leachates. Treatments included, simulated acid rain (AR), phosphogypsum + vermicompost...
Αλέξανδρος Γ. Σφακιανάκης
13m
Long‐term evolving profile of childhood autoimmune blistering diseases: Retrospective study on 38 children...
Long‐term evolving profile of childhood autoimmune blistering diseases: Retrospective study on 38 childrenA. Welfringer‐Morin  L. Bekel  N. Bellon  A. Gantzer  O. Boccara  S. Hadj‐Rabia  S. Leclerc‐Mercier  A Frassati‐Biaggi  S. Fraitag  C. BodemerFirst published: 31 January 2019 https://doi.org/10.1111/jdv.15456Funding sources There was no funding source supporting this work.Conflicts of interest The authors report no conflict of interest.Read the full textePDFPDFTOOLS SHAREAbstractBackgroundAutoimmune...
Αλέξανδρος Γ. Σφακιανάκης
18m
Demographics, healthcare utilization and drug use in children and adults with atopic dermatitis in Denmark:...
Demographics, healthcare utilization and drug use in children and adults with atopic dermatitis in Denmark: a population‐based cross‐sectional studyY.M.F. Andersen  A. Egeberg  L. Skov  J.P. ThyssenFirst published: 11 January 2019 https://doi.org/10.1111/jdv.15424Conflicts of interest Dr. Andersen has received research funding from the Lundbeck Foundation, Aage Bang Foundation and A.P. Møller Foundation. Dr. Thyssen has received research a grant from the Lundbeck Foundation attended advisory boards...
Αλέξανδρος Γ. Σφακιανάκης
19m
DNA copy number imbalances in primary cutaneous lymphomas G. Gug  Q. Huang  E. Chiticariu  C. Solovan ...
DNA copy number imbalances in primary cutaneous lymphomasG. Gug  Q. Huang  E. Chiticariu  C. Solovan  M. BaudisFirst published: 19 January 2019 https://doi.org/10.1111/jdv.15442Conflicts of interest We have no conflict of interest to declare.Funding sources Swiss National Science Foundation (IZERZ0_142305); UEFISCDI România.Read the full textePDFPDFTOOLS SHAREAbstractBackgroundCutaneous lymphomas (CL) represent a clinically defined group of extranodal non‐Hodgkin lymphomas harbouring heterogeneous...
Αλέξανδρος Γ. Σφακιανάκης
20m
Rapid onset of action of calcipotriol/betamethasone dipropionate cutaneous foam in psoriasis, even in...
Rapid onset of action of calcipotriol/betamethasone dipropionate cutaneous foam in psoriasis, even in patients with more severe diseaseA.E. Pink  A. Jalili  P. Berg  P.G. Calzavara‐Pinton  P. de la Cueva Dobao  D. Thaçi  M. Torpet  K.L. Jensen S. SegaertFirst published: 27 March 2019 https://doi.org/10.1111/jdv.15398Conflicts of interest Andrew Pink has served as an advisor, steering group member or lectured for Almirall, LEO Pharma, Lilly, Sanofi, Novartis and La Roche‐Posay. Ahmad Jalili has been...
Αλέξανδρος Γ. Σφακιανάκης
21m
Position statement for the diagnosis and management of anogenital warts
C. O'Mahony  M. Gomberg  M. Skerlev  A. Alraddadi  M.E. de las Heras‐Alonso  S. Majewski  E. Nicolaidou  S. Serdaroğlu  Z. Kutlubay  M. Tawara  A. Stary  A. Al Hammadi  M. CusiniFirst published: 10 April 2019 https://doi.org/10.1111/jdv.15570Conflict of interest Authors are responsible for disclosing all financial and personal relationships between themselves and others that might be perceived by others as biasing their work. To prevent ambiguity, authors must state explicitly whether potential conflicts...
Αλέξανδρος Γ. Σφακιανάκης
23m
Immunohistochemical analysis of class‐switched subtype of primary cutaneous marginal zone lymphoma in...
Immunohistochemical analysis of class‐switched subtype of primary cutaneous marginal zone lymphoma in terms of inducible skin‐associated lymphoid tissue (iSALT)Toshiaki Kogame  Tomoya Takegami  Tatsuhiro Sakai  Tatsuki Kataoka  Masahiro Hirata  Fatimah Mohammad Budair  Chiyuki Ueshima  Miho Matsui  Takashi Nomura  Kenji KabashimaFirst published: 24 May 2019 https://doi.org/10.1111/jdv.15703This article has been accepted for publication and undergone full peer review but has not been through the copyediting,...
Αλέξανδρος Γ. Σφακιανάκης
26m
Ultrasound as a Diagnostic and Management Tool in Hidradenitis Suppurativa Patients: A Multicenter Study...
Ultrasound as a Diagnostic and Management Tool in Hidradenitis Suppurativa Patients: A Multicenter StudyA Martorell  F Alfageme Roldán  E Vilarrasa Rull  R Ruiz‐Villaverde  J Romaní De Gabriel  F García Martínez  D Vidal Sarro  M Velasco Pastor  C Ciudad Blanco  J M Segura Palacios … See all authorsFirst published: 24 May 2019 https://doi.org/10.1111/jdv.15710This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination...
Αλέξανδρος Γ. Σφακιανάκης
29m
Benign and suspicious pink tumors : According to the high sensitivity model of the Menzies score, 129 (12.9%) lesions were considered as non‐suspicious (of which 16 were false negative) and 871 (87.1%) as suspicious (of which 212 were false positive), with 97.6% sensitivity, 34.8% specificity. According to the high specificity model, 370 (37%) lesions were evaluated as non‐suspicious (of which 105 were false negative) and 630 (63%) as suspicious (of which 60 were false positive), with 84.4% sensitivity, 81.5% specificity. Concerning the prevalent criterion method, 316 (31.6%) lesions were evaluated as non‐suspicious (of which 46 were false negative) and 684 (68.4) as suspicious (of which 55 were false positive), with 93.2% sensitivity and 83.1% specificity.
The prevalent dermoscopic criterion to distinguish between benign and suspicious pink tumorsTeresa Russo  Riccardo Pampena  Vincenzo Piccolo  Roberto Alfano  Chryssoula Papageorgiou  Zoe Apalla  Caterina Longo  Aimilios Lallas  Giuseppe ArgenzianoFirst published: 24 May 2019 https://doi.org/10.1111/jdv.15707This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences...
Αλέξανδρος Γ. Σφακιανάκης
30m
Evaluation of medical and surgical treatments for hidradenitis suppurativa using real‐life data from...
Evaluation of medical and surgical treatments for hidradenitis suppurativa using real‐life data from the Scandinavian registry (HISREG)Ø. Grimstad  T. Tzellos  D.N. Dufour  Ø. Bremnes  I.M. Skoie  I. Snekvik  E. Jarnæss  A. Kyrgidis  G. IngvarssonFirst published: 19 November 2018 https://doi.org/10.1111/jdv.15353 Cited by: 1Conflict of Interest The other authors state no conflict of interest.Funding source AbbVie paid for the extraction of data from the HISREG database and for the statistical analyses...
Αλέξανδρος Γ. Σφακιανάκης
32m
Resveratrol and siRNA in combination reduces Hsp27 expression and induces caspase-3 activity in human...
Resveratrol and siRNA in combination reduces Hsp27 expression and induces caspase-3 activity in human glioblastoma cellsAbstractGBM cells can easily gain resistance to conventional therapy, and therefore treatment of glioblastoma multiforme (GBM) is difficult. One of the hallmark proteins known to be responsible for this resistance is heat shock protein 27 (Hsp27) which has a key role in the cell survival. Resveratrol, a natural compound, exhibits antitumor effects against GBM, but there are no reports...
Αλέξανδρος Γ. Σφακιανάκης
34m
HSP72 expression is specific to skeletal muscle contraction type Abstract Exercise is capable of inducing...
HSP72 expression is specific to skeletal muscle contraction typeAbstractExercise is capable of inducing the cellular stress response and increasing skeletal muscle heat shock protein (HSP) content. HSPs function as molecular chaperones and play roles in facilitating protein folding thereby contributing to muscle proteostasis. To determine the relationship between muscle contraction types, muscle damage, and HSP content, one tibialis anterior (TA) muscle from male Sprague-Dawley rats (n = 5/group)...
Αλέξανδρος Γ. Σφακιανάκης
34m
Η αιτία των εκλογών είναι βαθύτερη : Γιατί θα ψηφίσω Μητσοτάκη/ΝΔ
Του Μανούσου Μαραγκουδάκη*https://www.liberal.gr/apopsi/giati-tha-psifiso-kuriako/253111Δεν είχα ψηφίσει ποτέ ΝΔ μέχρι την μεγάλη κρίση. Όταν την ψήφισα, κατά την ιλιγγιώδη άνοδο του ΣΥΡΙΖΑ, ο λόγος ήταν να αποτρέψω με την ψήφο μου την μεγάλη καταστροφή. Ήταν το καλύτερο που θα μπορούσαμε να περιμένουμε αν λάβουμε υπόψη την κατάσταση που ήταν τότε η χώρα. Τώρα όμως, πάνω στα αποκαΐδια της διακυβέρνησης ΣΥΡΙΖΑ, μεγάλες μεταρρυθμίσεις είναι πράγματι δυνατές. Και πιστεύω ότι ο Κυριάκος είναι ο κατάλληλος...
Αλέξανδρος Γ. Σφακιανάκης
35m
Expression and localization of heat-shock proteins during skeletal muscle cell proliferation and differentiation...
Expression and localization of heat-shock proteins during skeletal muscle cell proliferation and differentiation and the impact of heat stressAbstractSkeletal myogenesis is a coordinated sequence of events associated with dramatic changes in cell morphology, motility, and metabolism, which causes cellular stress and alters proteostasis. Chaperones, such as heat-shock proteins (HSPs), play important roles in limiting cellular stresses and maintaining proteostasis, but whether HSPs are specifically...
Αλέξανδρος Γ. Σφακιανάκης
42m
Hippo/Mst1 overexpression induces mitochondrial death in head and neck squamous cell carcinoma via activating...
Hippo/Mst1 overexpression induces mitochondrial death in head and neck squamous cell carcinoma via activating β-catenin/Drp1 pathwayAbstractMammalian Ste20-like kinase 1 (Mst1) is associated with cell apoptosis. In the current study, we explored the regulatory effects of Mst1 on squamous cell carcinoma of the head and neck (SCCHN) in vitro. SCCHN Cal27 cells and Tu686 cells were transfected with adenovirus-loaded Mst1 to detect the role of Mst1 in cell viability. Then, siRNA against Drp1 was transfected...
Αλέξανδρος Γ. Σφακιανάκης
43m
Cell Stress and Chaperones
Hippo/Mst1 overexpression induces mitochondrial death in head and neck squamous cell carcinoma via activating β-catenin/Drp1 pathwayAbstractMammalian Ste20-like kinase 1 (Mst1) is associated with cell apoptosis. In the current study, we explored the regulatory effects of Mst1 on squamous cell carcinoma of the head and neck (SCCHN) in vitro. SCCHN Cal27 cells and Tu686 cells were transfected with adenovirus-loaded Mst1 to detect the role of Mst1 in cell viability. Then, siRNA against Drp1 was transfected...
Αλέξανδρος Γ. Σφακιανάκης
43m
Neurological Sciences
Correction to: A review of electrophysiological studies of lower motor neuron involvement in amyotrophic lateral sclerosisThe published version of this article unfortunately contained a mistake. The sequence of authorship and the corresponding author is incorrect. The correct sequence and corresponding author is presented here.A case of foreign accent syndrome in a patient affected by a complex functional movement disorderAccuracy of MDS-UPDRS section IV for detecting motor fluctuations in Parkinson's...
Αλέξανδρος Γ. Σφακιανάκης
45m

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480