Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
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Παρασκευή 28 Σεπτεμβρίου 2018
Promising Scandium Radionuclides for Nuclear Medicine: A Review on the Production and Chemistry up to In Vivo Proofs of Concept
Promising Scandium Radionuclides for Nuclear Medicine: A Review on the Production and Chemistry up to In Vivo Proofs of Concept
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
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miRNA-448 inhibits cell growth by targeting BCL-2 in hepatocellular carcinoma
Increasing evidence indicates that aberrant micro (mi)RNA-448 expression plays a critical role in the progression of several human cancers. However, the function of miRNA-448 in hepatocellular carcinoma (HCC) has not been fully investigated.
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miRNA-448 inhibits cell growth by targeting BCL-2 in hepatocellular carcinoma
Increasing evidence indicates that aberrant micro (mi)RNA-448 expression plays a critical role in the progression of several human cancers. However, the function of miRNA-448 in hepatocellular carcinoma (HCC) has not been fully investigated.
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MedixSafe to exhibit at EMS World Expo Booth #547
Visit us at EMS World Expo Booth #547 to see the latest in narcotics and key security!
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Two major alternative splice variants of beta-TrCP1 interact with CENP-W with different binding preferences
Abstract
Beta-transducin repeat containing protein 1 (β-TrCP1) is a versatile F-box protein that is responsible for substrate recognition of SCFβ-TrCP1 ubiquitin ligase. In human cells, two major alternatively spliced isoforms (b and f) of β-TrCP1 were found. Recently, we identified that CENP-W interacts with the β-TrCP1 and regulates the cellular distribution of β-TrCP1. In this study, we examined whether CENP-W, a new kinetochore component, may differentially regulate the two major isoforms of human β-TrCP1 (b and f), especially in the cytoplasmic-nuclear shuttling of β-TrCP1. An in vivo binding assay was performed to examine whether CENP-W binds differently to the two isoforms of β-TrCP1. EGFP-conjugated β-TrCP1 isoforms were co-transfected with NLS-defective mutant CENP-W and their cellular distribution were observed using a fluorescence microscopy. Although CENP-W interacts with both b and f isoforms, it has a greater affinity for the b isoform rather than f isoform. Moreover, CENP-W effectively regulates the nuclear-cytoplasmic shuttling of these two β-TrCP1 isoforms, but with a slight preference towards the b isoform. The Elongin C-binding motif existing in the b isoform may be involved in their specific association. CENP-W showed a higher affinity toward the β-TrCP1 b isoform, and translocated isoform b more efficiently than isoform f, which may allow a fine regulation of of β-TrCP1 in the cells.
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Neonatal abstinence syndrome: Infants falling victim to the opioid crisis
Learn how infants who were exposed to opioids present while suffering from withdrawal
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Rare loss of function variants in candidate genes and risk of colorectal cancer
Abstract
Although ~ 25% of colorectal cancer or polyp (CRC/P) cases show familial aggregation, current germline genetic testing identifies a causal genotype in the 16 major genes associated with high penetrance CRC/P in only 20% of these cases. As there are likely other genes underlying heritable CRC/P, we evaluated the association of variation at novel loci with CRC/P. We evaluated 158 a priori selected candidate genes by comparing the number of rare potentially disruptive variants (PDVs) found in 84 CRC/P cases without an identified CRC/P risk-associated variant and 2440 controls. We repeated this analysis using an additional 73 CRC/P cases. We also compared the frequency of PDVs in select genes among CRC/P cases with two publicly available data sets. We found a significant enrichment of PDVs in cases vs. controls: 20% of cases vs. 11.5% of controls with ≥ 1 PDV (OR = 1.9, p = 0.01) in the original set of cases. Among the second cohort of CRC/P cases, 18% had a PDV, significantly different from 11.5% (p = 0.02). Logistic regression, adjusting for ancestry and multiple testing, indicated association between CRC/P and PDVs in NTHL1 (p = 0.0001), BRCA2 (p = 0.01) and BRIP1 (p = 0.04). However, there was no significant difference in the frequency of PDVs at each of these genes between all 157 CRC/P cases and two publicly available data sets. These results suggest an increased presence of PDVs in CRC/P cases and support further investigation of the association of NTHL1, BRCA2 and BRIP1 variation with CRC/P.
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Corrigendum to “New adapiform primate of Old World affinities from the Devil's Graveyard Formation of Texas” [J Hum Evol 61 (2011) 156–168]
Publication date: December 2018
Source: Journal of Human Evolution, Volume 125
Author(s): E. Christopher Kirk, Blythe A. Williams
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Editorial Board
Publication date: November 2018
Source: Journal of Human Evolution, Volume 124
Author(s):
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Criteria wanted. Is the brain dead or alive?
Publication date: Available online 27 September 2018
Source: Clinical Neurophysiology
Author(s): Mark M. Stecker
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Impact of non-invasive continuous blood pressure monitoring on maternal hypotension during cesarean delivery: a randomized-controlled study
Abstract
Purpose
This study aimed to investigate the efficacy of the ClearSight™ system (Edwards Lifesciences, Irvine, CA) for reducing the incidence of hypotension compared with the traditional oscillometric blood pressure monitoring in cesarean delivery under spinal anesthesia.
Methods
Forty patients undergoing cesarean delivery under spinal anesthesia were enrolled. The patients were randomly divided into two groups (Control and ClearSight groups). All patients received spinal anesthesia using 0.5% hyperbaric bupivacaine (11.5 mg) and fentanyl (10 µg). Blood pressure was managed with the same protocol using the ClearSight™ system (ClearSight group) and oscillometric blood pressure monitoring (Control group). Furthermore, we compared the accuracy of the ClearSight™ system with the traditional oscillometric monitoring for blood pressure measurement using Bland–Altman, four-quadrant plot, and polar plot analyses.
Results
The incidence of hypotension was significantly lower in the ClearSight group from induction to delivery (45% vs. 0%, p < 0.001) and to the end of surgery (50% vs. 20%, p = 0.049). Intraoperative nausea occurred more frequently in the Control group (45% vs. 10%, p = 0.012). The ClearSight™ system demonstrated acceptable accuracy with a bias of − 4.3 ± 11.7 mmHg throughout the procedure. Four-quadrant analysis revealed an excellent trending ability of the ClearSight™ system with a concordance rate of approximately 95%. In the polar plot analysis, the angular bias and concordance rate were − 13.5° ± 19.0° and 76.9%, respectively.
Conclusions
The accuracy and trending ability of the ClearSight™ system for blood pressure measurement was clinically acceptable in cesarean delivery under spinal anesthesia, leading to reductions in maternal hypotension and nausea.
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Helicobacter pylori status and risks of metachronous recurrence after endoscopic resection of early gastric cancer: A systematic review and meta-analysis
Journal of Gastroenterology
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Short‐term and midterm outcomes of single‐incision laparoscopic surgery for right‐sided colon cancer
Asian Journal of Endoscopic Surgery, EarlyView.
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Simultaneous laparoscopic left hemicolectomy and spleen‐preserving distal pancreatectomy for descending colon cancer with pancreatic invasion
Asian Journal of Endoscopic Surgery, EarlyView.
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Robotic surgery in pediatric urology: Current status
Asian Journal of Endoscopic Surgery, EarlyView.
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Low dose administration of bleomycin leads to early alterations in lung mechanics
Experimental Physiology, Volume 0, Issue ja, -Not available-.
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Alteration of the affective modulation of the startle reflex during antidepressant treatment
Psychophysiology, EarlyView.
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Neurocognitive mechanisms of emotion‐related impulsivity: The role of arousal
Psychophysiology, EarlyView.
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Measuring the conditioned response: A comparison of pupillometry, skin conductance, and startle electromyography
Psychophysiology, EarlyView.
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Update on the Use of Thiopurines and Methotrexate in Inflammatory Bowel Disease
Abstract
Purpose of Review
The increased use of biologic agents over the past two decades has led to a reappraisal of the role of the immunomodulators (thiopurines and methotrexate) in the treatment of inflammatory bowel disease. The purpose of this review is to summarize recent data on the use of thiopurines and methotrexate either as monotherapy or as part of combination therapy with biologic agents.
Recent Findings
Recent studies have addressed the need for concomitant immunomodulatory therapy in treatment-naïve patients starting anti-TNF-α therapy, the appropriate dose of the immunomodulator in this setting, the minimum duration of combination therapy, and the possible mechanisms by which immunomodulators enhance the effectiveness of anti-TNF-α agents. Little is known about the role of immunomodulators in combination with agents belonging to other classes of biologic therapies. Recent studies have shown that methotrexate is not effective in inducing or maintaining remission in ulcerative colitis. Finally, several studies have broadened our understanding of the infection and malignancy risks of the immunomodulators.
Summary
Immunomodulators continue to have a place in the treatment of inflammatory bowel disease. However, with the ever-increasing list of biologic agents, properly positioning the immunomodulators within the overall therapeutic scheme is a complicated task. In order to optimize outcomes, each patient requires an individualized approach, which takes into account risks, benefits, cost, alternatives, and patient preferences.
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