Σάββατο, 28 Οκτωβρίου 2017

Corrigendum to “Graph analysis of EEG resting state functional networks in dyslexic readers” [Clin. Neurophysiol. 127(9) (2016) 3165–3175]

We regret to inform you about a calculation error we recently detected in our published article: Fraga González G, Van der Molen MJW, Žarić G, Bonte M, Tijms J, Blomert L, Stam CJ, Van der Molen MW. Graph analysis of EEG resting state functional networks in dyslexic readers. Clin Neurophysiol. 2016 Sep; 127(9):3165–3175. doi:http://ift.tt/2yYuBal. Epub 2016 Jul 4. PubMed PMID: 27476025. We re-analyzed the data after discovering this error to determine the impact it had on the results.

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Contraction response to muscle percussion: a reappraisal of the mechanism of this bedside test

The contraction response to muscle percussion was first described in 1858 by Schiff who called it "idiomuscular contraction" in the belief that it was of muscular origin. Subsequently, it was noted that this response was diminished in patients with primary myopathic disorders (Babinski and Jarkowski, 1911; Patel and Swami, 1969) and in case of denervation (André-Thomas and de Ajuriaguerra, 1949), prolonged in patients with myotonia (Dejerine, 1914), and retained (Guillain et al., 1916) or even enhanced (Ropper et al., 1991) in Guillain-Barré patients.

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Revisiting interhemispheric imbalance in chronic stroke: a tDCS study

The immense burden of stroke-related disability has led to the development of noninvasive brain stimulation (NIBS) as a possible approach to augment neurorehabilitation of the paretic upper limb (Ackerley et al., 2010). Transcranial direct current stimulation (tDCS) is a polarity-dependent neuromodulatory technique that has demonstrated some benefit to motor function at the chronic stage (>6 months) post stroke, but effect sizes have varied (Jacobson et al., 2012; Kang et al., 2015).

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Frontal infraslow activity marks the motor spasms of anti-LGI1 encephalitis

The clinical and electrographic features of seizures in anti-LGI1 encephalitis are distinct from those seen in other autoimmune encephalitides or non-encephalitic epilepsies. The recognition of unusual lateralized motor spasms, which have come to be known as faciobrachial dystonic seizures (FBDS) (Irani et al., 2011a), has greatly facilitated early clinical diagnosis of the condition. Electrographically, a pattern of unusually frequent subclinical temporal lobe seizures in the absence of interictal spikes has been identified as an independent diagnostic marker (Andrade et al., 2011a,b; Steriade et al., 2016).

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Reply to “The insular cortex and QTc interval in HIV+ and HIV- individuals: Is there an effect of sympathetic nervous system activity?”

The correspondence by Nagai et al. (2017a) raised several points regarding our interpretation of the lateralized effects for QTc interval length on resting functional connectivity (rsFC) of the ventromedial prefrontal cortex (VMPFC) (McIntosh et al., 2017). The authors first contend that if some form of sympathetic inhibition accounts for prolongation of the QT interval in a dog model then a similar mechanism, i.e., parasympathetic arousal, would be expected to correspond with longer QTc interval lengths in our sample of HIV+ and HIV-negative men.

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“Caught in the act”



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Adalimumab trough levels predict Crohn’s disease clinical course



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“Caught in the act”



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Adalimumab trough levels predict Crohn’s disease clinical course



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Charleston County EMS (SC) - Charleston County EMS

Voted one of the top tourist destinations in the world, Charleston County EMS serves over 1,100 square miles of historic and scenic areas including City of Charleston, Kiawah Island, and highly regarded beach communities on the Atlantic coastline. Charleston County is an EMS system that relies on Innovation, Trust, Compassion, Respect and Dedication to provide exceptional customer service to our community ...

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Acute effects of sex steroids on visual processing in male goldfish

Abstract

Elevations of sex steroids induced by social cues can rapidly modulate social behavior, but we know little about where they act within the nervous system to produce such effects. In male goldfish, testosterone (T) rapidly increases approach responses to the visual cues of females through its conversion to estradiol. Because aromatase is expressed in the retina, we tested if T can acutely influence retina responses to visual stimuli, and investigated the receptor mechanisms that may mediate such effects. Specifically, we measured FOS protein immunoreactivity to determine if T affects cellular responses to visual stimuli that include females, and used electrophysiology to investigate whether T can generally affect light sensitivity. We found that T acutely increased FOS responses to the simultaneous onset of light and the presence of female visual stimuli, both of which would normally be associated with early morning spawning, and increased electrophysiological responses to low intensity light pulses. Both effects were blocked by an estrogen receptor beta (ERβ) antagonist, indicating that T is likely being converted to estradiol (E2) and acting through an ERβ mediated mechanism to acutely modulate visual processing. Changes in sensory processing could subsequently influence approach behavior to increase reproductive success in competitive mating environments.



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Aneurysmal bone cysts and pathologic fracture associated with supernumerary ring chromosome 6 in two unrelated patients

Small supernumerary ring chromosome 6 (sSRC[6]) is a rare chromosomal abnormality characterized by a broad clinical phenotype. The spectrum of this disorder can range from phenotypically normal to severe developmental delay and congenital anomalies. We describe two unrelated patients with small SRCs derived from chromosome 6 with a novel bone phenotype. Both patients presented with a complex bone disorder characterized by severe osteopenia, pathologic fractures, and cyst-like lesions within the bone. Imaging revealed decreased bone mineral density, mutiple multiloculated cysts and cortical thinning. Lesion pathology in both patients demonstrated a bland cyst wall with woven dysplastic appearing bone entrapped within it. In patient 1, array comparative genomic hybridization (CGH) detected a tandem duplication of region 6p12.3 to 6q12 per marker chromosome. Cytogenetic analysis further revealed a complex patient of mosaicism with some cell lines displaying either one or two copies of the marker indicative of both tetrasomy and hexasomy of this region. Patient 2 was mosaic for a sSRC that encompassed a 26.8 Mb gain from 6p21.2 to 6q12. We performed an in-depth clinical analysis of a phenotype not previously observed in sSRC(6) patients and discuss the potential influence of genes located within this region on the skeletal presentation observed.



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Effectiveness of enhanced pulse oximetry sonifications for conveying oxygen saturation ranges: a laboratory comparison of five auditory displays

British Journal of Anaesthesia, 2017; 1–7, DOI 10.1093/bja/aex343

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Median Nerve Area Measurements Using Ultrasound: Importance of Proper Technique and Interpretation.

No abstract available

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Changes in Anxiety and Depression Are Mediated by Changes in Pain Severity in Patients Undergoing Lower-Extremity Total Joint Arthroplasty.

Background: Depression and anxiety are common comorbidities in chronic pain including osteoarthritis patients undergoing total joint arthroplasty (TJA). What is not clear is whether psychiatric comorbidity precedes the manifestation of painful states or represents a reaction to living with chronic pain and associated functional impairment. The objective of this research was to explore whether decreases in depressive and anxiety symptoms after lower-extremity TJA could be due to postsurgical reductions in pain. Methods: We conducted a secondary analysis of data from 1448 TJA patients enrolled in the Analgesics Outcome Study. Patients completed measures of pain intensity, functional status, and depressive and anxiety symptoms preoperatively and at 3 and 6 months postoperatively. Data were analyzed using a structural equation modeling approach. Results: We found that improvement in pain and physical function from baseline to 6 months postoperatively was associated with improvement in depression and anxiety symptoms. We also found that a change in overall body pain at 3 months after surgery significantly mediated changes in both the depression and anxiety scores at 6 months after surgery even when controlling for age, sex, baseline body pain, education, opioid use, and type of surgery. Conclusions: Presurgical affective symptoms not only have an effect on change in postsurgical pain, whereby lower preoperative scores on depression and anxiety were associated with lower postsurgical pain, but also postsurgical decreases in pain were associated with lower levels of depression and anxiety after surgery. Taking these points into consideration may prove useful in working toward better outcomes for TJA. Copyright (C) 2017 by American Society of Regional Anesthesia and Pain Medicine.

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