FORMULATION AND EVALUATION OF NIFIDEPINE MOUTH DISSOLVING TABLET BY SUBLIMATION TECHNIQUE

2016-10-16T02-20-53Z
Source: Indo American Journal of Pharmaceutical Research
Mr. Hemant D. Patil, Mr. Sachin S. Rane, Prof. (Dr.) Rajesh Y. Chaudhari, Prof. (Dr.) Vijay R. Patil.
Nifedipine, the prototype of the dihydropyridine class of calcium channel antagonists which used to treat Prinzmetal's angina, hypertension and other vascular disorders by blocking the calcium channels. In such cases, mouth dissolving dosage forms will be an effective solution for patient compliance and efficient medicine regimen. In the present research, mouth dissolving tablet of Nifedipine was made using various tabletiing aids. The prepared tablets were evaluated for weight, thickness, hardness, friability with disintegration time of less than 30 seconds and drug dissolution of about 75% achieved within 30 minutes. The prepared tablets were stability tested at 40°C having 75% Relative Humidity for 3 months and were found to be stable. Prepared mouth dissolving tablets of Nifedipine 10 mg was found to be bioequivalent under fasting and fed conditions.


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