STUDY OF INTERACTION BETWEEN DICLOFENAC SODIUM AND Boerhavia diffusa FOR ANTI-INFLAMMATORY ACTIVITY

2016-10-16T02-20-53Z
Source: Indo American Journal of Pharmaceutical Research
Thorat Rinku D, Joshi Yadhunath M*, Garge Vaibhavi N..
The present study was aimed at evaluation of pharmacodynamic interaction between Diclofenac sodium powder and Punarnava capsules containing Boerhavia diffusa extract using carrageenan induced rat paw edema for anti-inflammatory activity. Boerhavia diffusa (Nyctaginaceae) is one of the significant indigenous medicinal plants with a broad spectrum of therapeutic activity. The medicative value of this herb has been reported for analgesic, anti-inflammatory, carminative, anti-diabetic and diuretic properties. The inflammation induced with the help of carrageenan in hind paw of albino rats was measured using plethysmometer. For this activity treatment groups received disease control induced 1% Carrageenan (0.1 ml), Diclofenac sodium (10mg/kg), Boerhavia diffusa 200mg/kg and combination group Diclofenac sodium (10mg/kg) with Boerhavia diffusa (200mg/kg) .The anti-inflammatory activity is more effective in Group II Carrageenan induction with oral administration of Diclofenac sodium of 10mg/kg/i.p. compared to Group IV Carrageenan is subcutaneously induced along with the oral administration of combination of Diclofenac sodium of 10mg/kg/ip with Boerhavia diffusa of 200mg/kg/i.p.


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