DESIGN AND EVALUATION OF CLARITHROMYCIN SUSTAINED RELEASE TABLETS USING ISOLATED NATURAL POLYSACCHARIDE

2016-10-16T02-20-53Z
Source: Indo American Journal of Pharmaceutical Research
Nishad Km*, B. Arul.
The present investigation was to isolate natural polymers like tamarind seed polysaccharide, followed by formulation of clarithromycin sustained release tablets. The polymer, drug and dug excipient mixtures were subjected to preformulation studies. The tablets were evaluated for in-process studies, in-vitro drug release studies in different PH solutions , kinetic and stability studies. FTIR studies shown that there is no interaction between drug and polymers. Clarithromycin is semi synthetic macrolide antibiotic used as anti bacterial agent. It is used for the treatment of H.pylori infection in peptic ulcer. The drug release from the optimized formulation was extended for 16 hours. The optimized formulation were subjected to stability studies. The study concluded that tamarind seed polysaccharide polymer is a very effective natural polymer with an advantage of its biodegradation as well as sustained release mechanism.


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