EVALUATION OF ANTIEPILEPTIC AND ANTI-OXIDANT ACTIVITY OF Sapindus emarginatus Vahl FRUIT EXTRACTS

2016-10-16T06-25-49Z
Source: Indo American Journal of Pharmaceutical Research
Afzal Nazneen*, Nerella Mounika, P. Chandramohan, K. Baikuntha Prusty.
Sapindus emarginatus is important indigenous plant with lots of traditional importance belongs to family sapindaceae. It is commonly called as Soap nut tree which is found in most of the hilly regions of India. It possesses various activities such as surfactant, mild detergent, anti-inflammatory, antipruritic, antihyperlipidemic, antimicrobial, CNS, emetic, hair tonic, nasal insufflations. The aim of the present work is to extract chemical constituents and perform the anti-epileptic and anti convulsant activity. Phytochemical screening of the Sapindus emarginatus extracts showed the presence alkaloids, carbohydrates, phenols, flavonoids, saponins fixed oils & fats. In the present study, the results showed that the test compound significantly decreased the Ach in rats brain .Whereas the AchE level decrease in brain during epileptic seizures the results showed that the test compound significantly increased AchE in rat brain. Test compound at the doses of 300mg/kg significantly increased levels of antioxidant enzymes such as superoxide dismutase and glutathione reductase on rat brain.


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