CAFFEIC ACID IMPROVES MEMORY OF COLLAGENASE-INDUCED BRAIN STROKE IN RATS

2016-10-16T02-20-53Z
Source: Indo American Journal of Pharmaceutical Research
Amandeep Kaur, Nitin Bansal*.
The present study is an effort to demonstrate the role of caffeic acid in the management of Collagenase - ICV induced brain stroke in rats. Wistar rats either sex; 200-250 g were divided into 6 groups. Caffeic acid was administered daily in 3 doses (10, 30 and 50 mg/kg; p.o.) to rats for 28 successive days. Brain stroke was induced in rats by intracerebroventricular (ICV) injection of collagenase (10 μl/ml) using stereotaxic appratus. Behavioral assessment of rats was carried with the help of Elevated plus Maze and Novel objective recognition task. After behavioral evaluation, the animals were sacrificed and the brains TBARS, GSH levels, Nitrite, Catalase and protein levels were estimated. Collagenase induced stroke rats showed significant increase in transfer latency of rats in elevated plus maze studies and showed significant difference in exploration of the novel and familiar object in retention trial of rats in novel object recognition task as compared to sham rats. Collagenase treated rats showed significant decrease in brain GSH, catalase, protein levels and increase in brain TBARS and nitrite levels. Administration of caffeic acid (10, 30 and 50 mg/kg; p.o) for 28 days reduced (p


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