DEVELOPMENT AND VALIDATION OF A SIMPLE UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF LORNOXICAM IN PH 7.4 PHOSPHATE BUFFER

2016-10-16T02-20-53Z
Source: Indo American Journal of Pharmaceutical Research
Dr. Ayya Rajendra Prasad, Bannaravuri Thireesha.
The aim of the present work is to develop sensitive, simple, accurate, precise and cost effective UV-spectrophotometric method for the determination of lornoxicam, an non-steroidal anti-inflammatory drug in pH7.4 phosphate buffer. This developed method is useful for the determination of in vitro drug release fromoral controlled release dosage forms. The calibration graph is linear over the range of 614 μg ml-1with a correlation coefficient (r2) of 0.9992. The accuracy and precision of the method was evaluated based on intra-day and inter-day variations. The accuracy of the method was further confirmed by standard addition procedure. The proposed methods were successfully applied to the determination of lornoxicam in pH 7.4 phosphate buffer which is used as a dissolution medium.


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