Resting state connectivity in neocortical epilepsy: The epilepsy network as a patient-specific biomarker

Contrary to its historical roots, localization related epilepsy (LRE) is now increasingly recognized as a network disorder (Bartolomei et al., 2001, Spencer, 2002, van Diessen et al., 2013). With this paradigm shift in our understanding comes the need to reconsider all aspects of how we evaluate and manage patients afflicted with this burdensome disease. Clinicians have historically been trained to identify the seizure "focus", sometimes at the expense of considering the more diffuse pathology implicated in many epileptogenic substrates.

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