Effective Weight Loss and Maintenance by Intensive Start with Diet and Exercise

Introduction This 24-month study aimed to determine if exercise intervention added to weight loss treatment at 6 months is effective for weight loss and maintenance. Methods A total of 120 obese subjects (BMI > 30) were randomly assigned to behavioural modification (iBM) (n = 30), behavioural modification + exercise from 0 to 3 months (CWT1) (n = 30), behavioural modification + exercise from 6 to 9 months (CWT2) (n = 30), and a control group (CON) (n = 30). Health behavior, weight, waist circumference, and 2-hour glucose tolerance test with insulin measurements were measured at 0, 3, 9, and 24 months. Results Eighty-five subjects (mean age 46 years, BMI 36.3, 75.3% women) completed the trial. A significant weight loss occurred in CWT1 (−8.5 kg, p > 0.001), iBM (−5.5 kg, p > 0.001), and CWT2 (−4.4 kg, p = 0.007). CWT1 showed the highest reduction in waist circumference at 9 months (mean difference −11.5 cm, p

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