Exploration of cardiac sympathetic adrenergic nerve activity in narcolepsy

Narcolepsy type 1 (NT1) is an orphan sleep disorder caused by the selective and irreversible loss of hypocretin/orexin neurons that widely project to brain, brainstem and intermediolateral nucleus neurons of the spinal cord, and have key roles in autonomic and cardiovascular (CV) regulation (Dun et al. 2000; Dauvilliers et al. 2007; Grimaldi et al. 2014). Hypocretin-deficient mice show lower arterial blood pressure (BP) during wakefulness and blunted non-rapid eye movement (REM) sleep and REM sleep-related BP decreases compared with wild type animals (Bastianini et al.

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