Recent findings support positive effects of acute aerobic exercise on worry, state anxiety, and feelings of energy and fatigue among young adult women with subclinical, or analogue, Generalized Anxiety Disorder (GAD). However, exercise effects among young adult men with analogue GAD are unstudied. Purpose This study replicated initial findings of positive effects of acute vigorous-intensity aerobic exercise on worry, state anxiety, and feelings of energy and fatigue among young adult women with analogue GAD, examined responses among young adult men with analogue GAD, and explored sex-related differences and moderation by physical activity level, trait anxiety, depression, and poor sleep status. Methods Thirty-five young adults (21.4±2.3y; 19M; 16F) with Penn State Worry Questionnaire scores ≥45 (60±8) completed two counterbalanced 30-min conditions: treadmill running at ~71.2%±0.04% heart rate reserve and seated quiet rest. Outcomes included worry, worry engagement, absence of worry, state anxiety, and feelings of energy and fatigue. Results No outcome or moderator differed at baseline between sexes. Exercise significantly improved state anxiety (p
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