Purpose To describe cardiorespiratory, quadriceps oxygenation, and muscle fatigue responses during a one-legged quadriceps isokinetic endurance exercise in COPD and control subjects. Methods Fourteen patients with COPD and 14 control subjects performed a cardiopulmonary cycling exercise test (CPET) to exhaustion to assess peak oxygen consumption (V˙O2peak), minute ventilation (V˙E2peak) and heart rate (HRpeak). They also performed a quadriceps isokinetic endurance exercise consisting in 30 maximal knee-extensions at 90°/s with continuous monitoring of expired gases, cardiac output (CO) and oxygenation of the quadriceps by near-infrared spectroscopy. Total muscle work and fatigue index were also quantified. Results The total muscle work developed during the quadriceps isokinetic endurance exercise was 2.25±0.57 kJ in COPD and 3.12±0.60 kJ in controls, p
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