Neuropathic pain, dysautonomia, and nerve hyperexcitability: Expanding the spectrum of LGI1 autoimmunity

Antibodies to Leucine-rich Glioma Inactivated 1 (LGI1) protein have primarily been associated with limbic encephalitis (van Sonderen et al., 2016). However, a more widespread autoantibody testing has recently allowed to expand the spectrum of LGI-1 autoimmunity, and peripheral impairment is increasingly reported, whether or not in association with central nervous system involvement (van Sonderen et al., 2016; Klein et al., 2012; Gadoth et al., 2017). The clinical and electrophysiological phenotype associated with LGI1-positive peripheral neuropathy has not been fully elucidated yet, and neurologists are not necessarily familiar with this entity.

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