Urinary N-acetyl-β-D-glucosaminidase (NAG) and Renal Tubular Injury in Mild Preeclampsia

2016-12-30T05-45-32Z
Source: Cukurova Medical Journal
Mustafa Ulubay, Fahri Burçin Fıratlıgil, Mustafa Öztürk, Özlem Öztürk, Uğur Keskin, Ulaş Fidan, Hüseyin Pehlivan, Müfit Cemal Yenen.
Background: This study aimed to evaluate the amount of N-acetyl-β-D-glucosaminidase(NAG) in the 24 h urine output of patients with normotensive pregnancies(control) group with mild preeclampsia(study) group and to detect the presence of renal tubular injury in mild preeclampsia patients. Methods: The study was conducted among 13 patients study group and 15 patients control group between January 2013 - January 2014.All pregnants were chosen from the third trimester (31-37 gestational week) to decrease the difference in the NAG measurement. The 24 h urine output and protein, glomerular filtration rate, systolic and diastolic arterial pressures, serum creatinine, and 24 h urine NAG values of the pregnants were calculated. Results: Statistical difference was not detected among gestational week, 24 h urine volume(mL), serum creatinine(mg/dL), and glomerular filtration rates of the control and the study groups. The differences of the 24 h urine protein(U/l), systolic and diastolic arterial blood pressures(mmHg), and 24 h urine NAG (p≤0.05) between groups were statistically significant. A significant correlation was found between the NAG values and 24 h urine protein. Conclusion: We found that in this study; 1)evaluating the impact of protein assessment along with NAG, which indicates both glomerular and tubular injuries, is important, and that 2) renal tubular injury occurs in patients with mild preeclampsia but it didnt make any changes of serum creatinine.


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