Pain perception in patients with chronic disorders of consciousness: what can limbic system tell us?

Whether or not and to what extent patients suffering from Unresponsive Wakefulness Syndrome (UWS) can perceive pain is still a great dilemma (Arbour 2013; Demertzi et al. 2009; Chatelle et al. 2014; Schnakers et al. 2012). Indeed, clinical experience suggests that UWS individuals do not feel pain since they show no more than reflexive behaviours following nociceptive stimuli, whereas Minimally Conscious State (MCS) subjects show pain-oriented responses. Indeed, UWS patients have a repertoire of pain-induced responses, including grimacing and crying, which are similar to those that are seen in conscious individuals.

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