GABAAergic dysfunction in the olivary-cerebellar-brainstem network may cause eye oscillations and body tremor

Opsoclonus and flutter are ocular oscillations consisting of continuous, involuntary, conjugate saccades without intersaccadic intervals. If these saccadic oscillations are purely horizontal, they are called ocular flutter; if they have horizontal, vertical and torsional components, they are called opsoclonus. Behavioral disturbances, cerebellar ataxia, and limb tremor may co-occur. Several infectious, paraneoplastic, metabolic, and toxic etiologies cause these disturbances, but how neural circuits generate the oscillations is not clear.

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