Evaluation of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Mean Platelet Volume in Patients with Knee Osteoarthritis

2016-12-30T05-45-32Z
Source: Cukurova Medical Journal
Emel Atar, Ayhan Aşkın.
Purpose: The purpose of the present study was to evaluate neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume levels in patients with knee osteoarthritis and explore their clinical significance. Material and Methods: The study included 92 patients with knee osteoarthritis and 57 healthy individuals.Age, sex, height, weight, body mass index, stage of knee osteoarthritis with Kellgren-Lawrence classification, total white blood counts, neutrophil, platelet, lymphocyte counts, c-reactive protein, sedimantation, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume values of the patients were analyzed retrospectively. Results:The present study found no significant difference in terms of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume values in patients with knee osteoarthritis when compared to the control group. C-reactive protein levels in patients with osteoarthritis were significantly higher than control group.Although neutrophil-to-lymphocyte ratio value of osteoarthritis patients was moderate high compared to the control group was not statistically significant. Conclusion:In clinical practice, it has been reported that hemogram parameters such as mean platelet volume, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio can be used as markers of systemic inflammation in different diseases. Osteoarthritis has been increasingly recognized to include low grade inflammation, often subclinical. Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume values are cheap and practical. But these rates to determine the severity of disease in patients with knee osteoarthritis are not considered as a suitable parameterin our study.


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