INVESTIGATION OF VIRULENCE FACTORS OF PSEUDOMONAS AERUGINOSA STRAINS ISOLATED FROM VARIOUS CLINICAL SAMPLES

2016-12-30T05-45-32Z
Source: Cukurova Medical Journal
Salih Maçin, Fatma Nur Akdoğan Kıttana, Yakut Akyon Yilmaz.
Objective: Pseudomonas aeruginosa is an aerobic, non-spore forming, straight or slightly curved, gram-negative bacilli and it can grow at 42 °C. Virulence factors of P. aeruginosa are various and its morbidity, mortality and antibiotic resistance rates are increasing constantly. The aim of this study was to examine the virulence factors of P. aeruginosa isolates that isolated from various sites of the body. Material and Method:Isolates of patients that were identified as P. aeruginosa were included into the study (n:258). Identification was done in Hacettepe University Hospital Microbiology Laboratory. DNase, protease, elastase, pyocyanin, mucoid phenotype, haemolysis and motility tests were performed as phenotypic tests. Results: Positivity rates of the virulance factors are; 190 (73.6%) elastase, 170 (65.9%) protease, 222 (86%) motility, 56 (21.7%) pyocyanin, 205 (79.5%) hemolysis, 67 'si (26%) DNase and 53 (20.5%) mucoid phenotyp, respectively. Conclusion: Since the diversity of virulence factor produced by P. aeruginosa and antibiotic resistance rate increase, it causes difficult to treat infections. The data will provide an insight into new approaches to treatment.


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