Characteristics of CART Peptide-Immunopositive Cells in the Subventricular Zone of the Brain

Objectives. To study the cytoarchitectonics of the neuronal organization and distribution of CART peptide-immunopositive cells in the subventricular zone of the brain. Materials and methods. Frontal sections of the rat brain (n = 18) were studied using the Nissl, Golgi, and immunohistochemical methods with antibodies to CART (55–102). Specimens were analyzed by light microscopy. Results. CART peptide-immunopositive cells were detected in the subventricular zone of the inferior horn of the lateral ventricle in the paleoamygdala. These had round-oval bodies, one or two short processes and, in terms of their neuronal organization, were neuroblastomorphic neurons. Conclusions. The data obtained here provide evidence that cells in the subventricular zone of the paleoamygdala express CART peptide in health. This determines the high efficacy of neuroregenerative treatment using this substance.

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