Nature Reviews Genetics 18, 377 (2017). doi:10.1038/nrg.2017.17
Authors: Teddy Jégu, Eric Aeby & Jeannie T. Lee
Extensive 3D folding is required to package a genome into the tiny nuclear space, and this packaging must be compatible with proper gene expression. Thus, in the well-hierarchized nucleus, chromosomes occupy discrete territories and adopt specific 3D organizational structures that facilitate interactions between regulatory elements
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