Potential of Positron Emission Tomography for Studies of the Mechanisms of Development of Multiple Sclerosis (published data and authors’ results)

This article presents published data and results from our own studies of the use of positron emission tomography (PET) with different radiotracers in multiple sclerosis (MS). Information on the principles of PET is given and grounds are presented for performing PET studies with different radiopharmaceuticals. PET investigation results obtained in MS with different courses are presented, including investigations to identify the locations of neuron damage in the cortical gray matter, to assess microglial activation, and to study the link between glucose metabolism in the brain and the severity of cognitive impairment in MS, yielding new data on the pathogenesis and mechanisms of development of the disease.

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