1-1-55. Changes of resting-state functional connectivity during prism adaptation in healthy adults: A fMRI study

Publication date: June 2017
Source:Clinical Neurophysiology, Volume 128, Issue 6
Author(s): Daisuke Nishida, Katsuhiro Mizuno, Emi Yamada, Kenji Kato, Hiroki Ebata, Meigen Liu
Prism adaptation (PA) is one of the effective therapies for unilateral spatial neglect (USN), but its mechanism is not well understood. Under the hypothesis that PA is related to functional connectivity (FC) of visual attention network, we investigated the effects of the PA on FC in healthy adults with resting state functional magnetic resonance imaging (rsfMRI). Participants were 5 healthy right-handed volunteers. They wore prism glasses that deviate visual field to the right, and performed reaching task for the target without seeing the trajectory of their own hand. The angle of the prism glasses was gradually increased and the task was repeated 90 times. We estimated brain connectivity with rsfMRI before, immediately after, and one hour after the PA task. With pooled data of all the participants, the FC between left and right middle frontal gyrus decreased significantly immediately after the PA, and returned to baseline in one hour. Leftward deviation as a behavioral after effect seen immediately after the PA seemed to disappear in one hour. These results suggest that the FC in this region is modified by short term visuomotor adaptation. This study suggests that the PA can influence resting-state-functional connectivity between left and right visual attention network.



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