1-1-06. Repeated, cortical stimulation can modify the wideband cortical activity correlates of interictal epileptiform discharge

Electric cortical stimulation (ECS) is known to have suppressive effects on epileptic focus. However, the inhibitory mechanism remains to be elucidated. We investigated the effect of ECS on human epileptic focus by evaluating wideband cortical activities accompanied with interictal epileptiform discharges (IEDs). We recruited 9 patients with intractable partial epilepsy who underwent invasive pre-surgical evaluation with subdural electrodes. 50-Hz stimulation (0.3ms pulse, 1–15mA, 1–5s) was applied at seizure onset zone (SOZ) as a part of functional cortical mapping.

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