Exercise Attenuates High-Fat Diet-Induced Disease Progression in 3xTg-AD Mice.

Purpose: Little is known regarding the therapeutic role of exercise against the risk of a high-fat diet (HFD) for Alzheimer's disease (AD) and AD-like cognitive deficits. This study aimed to investigate the therapeutic effect of treadmill running against HFD-induced progression in AD neuropathology and cognitive impairments in the triple transgenic-AD (3xTg-AD) mice. Methods: The 3xTg-AD mice were assigned to a chow diet (control, n=10), a high-fat diet (HFD, n=10), or a high-fat diet combined with exercise (HFD+EX, n=10) group. Mice in the HFD were fed with a 60% fat diet for 20 weeks. The HFD+EX mice were additionally subjected to treadmill running. Results: Compared to the control mice, the HFD mice had impaired brain insulin signaling, exacerbated AD neuropathology, defects in synaptic stability/plasticity, and apoptotic neuronal cell death in conjunction with exacerbated cognitive deficits in the affected brain regions, which were all significantly alleviated in the HFD+EX mice. Conclusion: The current findings suggest that treadmill running protects against AD-like disease progression and cognitive deficits caused by a HFD in the 3xTg-AD mice. (C) 2016 American College of Sports Medicine

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