Effects of Nothrombel on Thrombin-Induced Formation of Thrombocyte-Leukocyte Complexes

The effects of Nothrombel on the thrombin-induced formation of thrombocyte-leukocyte complexes (TLC) were studied. Nothrombel was found to produce dose-dependent inhibition of TLC formation. Its activity was greater than that of reference drug aspirin. The 50% inhibition constant (EC₅₀) of Nothrombel was 1.75 μmol/ml, compared with greater than 1.75 μmol/ml for aspirin. The mechanism of inhibition of TLC formation by Nothrombel relates to the ability of this drug to suppress the expression of P-selectin by thrombocytes and the membrane complex GPIb-IX-V on membranes and the mobilization of cytoplasmic calcium in thrombocytes, and, evidently, an inhibitory action on the P₂Y₁₂ purine receptors of thrombocytes.

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