We report here our studies of the relationship between mitogen-activated secretion of cytokines by splenocytes and the nature of behavior in (C57BL/6 × DBA/2)F1 mice in environments with different levels of spatial complexity: simple, in the form of the home cage, an enriched cage, and a maze. Increases in aggressive and neurotic manifestations in social conditions occurring only in the enriched environment were accompanied by suppression of the secretion of interleukins IL-2, IL-4, IL-6, and IL-10 independently of their structural-functional properties. The opposite effect, with significant increases in the production of all the cytokines studied, was seen in the case of stereotypical goal-directed behavior in the maze. It is suggested that the cellular elements of the immune system – splenocytes – are involved in mediating the body's highly differentiated adaptive response induced by the social and cognition factors, the extent of which was determined by specific physiological-biochemical systems.
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